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Phenothiazine

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Identification
Molecular formula
C12H9N1S1
CAS number
92-84-2
IUPAC name
10H-phenothiazine
State
State

At room temperature, phenothiazine is a solid.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
371.00
Boiling point (Kelvin)
644.15
General information
Molecular weight
199.27g/mol
Molar mass
199.2690g/mol
Density
1.3067g/cm3
Appearence

Phenothiazine typically appears as a yellow to greenish-yellow crystalline powder. It is known for its bright fluorescent appearance under UV light.

Comment on solubility

Solubility of 10H-phenothiazine

10H-phenothiazine, with the chemical formula C12H9NS, exhibits some interesting solubility characteristics. This compound is known to be:

  • Insoluble in water: Due to its hydrophobic nature and molecular structure, 10H-phenothiazine does not dissolve well in aqueous solutions.
  • Slightly soluble in organic solvents: It shows moderate solubility in solvents such as ethanol, ether, and chloroform.
  • Able to dissolve in acidic or alkaline conditions: Under specific conditions, such as adjusting pH, it can exhibit altered solubility profiles.

These properties make 10H-phenothiazine an interesting compound for various applications, particularly in organic synthesis and pharmaceutical chemistry. As emphasized in *solubility studies*, the interaction of solutes with solvents can be complex and highly dependent on environmental factors, which ultimately influence the behavior of 10H-phenothiazine in practical applications.

In summary, while 10H-phenothiazine is largely insoluble in water, its solubility in organic solvents and response to pH changes can offer valuable insights for its utilization in scientific research and industry.

Interesting facts

Interesting Facts about 10H-phenothiazine

10H-phenothiazine is a fascinating compound that has garnered attention in various fields of research and application. Known for its unique structure, this compound features a three-ring system that contributes to its chemical properties and potential uses.

Key Highlights

  • Pharmacological Significance: 10H-phenothiazine is well-known in the pharmaceutical industry, particularly as a precursor for the synthesis of numerous antipsychotic medications. Its derivatives have played a significant role in the treatment of mental health disorders.
  • Diverse Applications: Beyond its medicinal use, 10H-phenothiazine has been employed in various other sectors:
    • As a dye in the textile industry.
    • In the preparation of pesticides and anti-fungal agents.
    • In research settings for its role as a redox-active compound.
  • Electron-Deficient Behavior: This compound exhibits interesting electron-deficient properties, making it useful in organic electronic applications, such as in organic solar cells and light-emitting diodes (LEDs).
  • Structural Chemistry: The distinctive structure of 10H-phenothiazine allows it to participate in various chemical reactions, including oxidation and reduction processes, which are vital in synthetic organic chemistry.

Quotes

As noted by chemist Arthur F. Benner, *"The innovative applications of 10H-phenothiazine highlight the beauty of how structure influences function in chemistry."*

Conclusion

In summary, 10H-phenothiazine is not just a compound of academic interest; it bridges the gap between theoretical research and practical applications. Its diverse uses, particularly in medicine and materials science, underscore its significance in ongoing scientific exploration.

Synonyms
PHENOTHIAZINE
10H-Phenothiazine
92-84-2
Thiodiphenylamine
Dibenzothiazine
Contaverm
Dibenzo-1,4-thiazine
Fenoverm
Phenosan
Feeno
Phenthiazine
Nemazine
Agrazine
Antiverm
Fenotiazina
Fentiazin
Helmetina
Lethelmin
Nemazene
Nexarbol
Padophene
Penthazine
Phenegic
Phenoverm
Phenovis
Phenoxur
Phenzeen
Souframine
Orimon
Reconox
Thiodiphenylamin
Wurm-Thional
AFI-Tiazin
Dibenzoparathiazine
Early bird wormer
10H-Phenothiazin
Dibenzo-p-thiazine
Fenothiazine
Tiodifenilamina
Biverm
Thiodifenylamine
Phenthiazinum
Danikoropa
ENT 38
Phenothiazinum
Caswell No. 652
XL-50
Phenothiazine [INN]
phenothiazin
CCRIS 5877
EPA Pesticide Chemical Code 064501
HSDB 5279
UNII-GS9EX7QNU6
GS9EX7QNU6
Fenotiazina [INN-Spanish]
NSC 2037
NSC-2037
EINECS 202-196-5
Phenothiazinum [INN-Latin]
MFCD00005015
BRN 0143237
ENT-38
DTXSID5021126
CHEBI:37931
AI3-00038
CHEMBL828
MLS000069413
DTXCID301126
EC 202-196-5
4-27-00-01214 (Beilstein Handbook Reference)
Phenothiazine (INN)
NCGC00091146-02
NCGC00091146-04
SMR000059045
Fenotiazina (INN-Spanish)
Phenothiazinum (INN-Latin)
PHENOTHIAZINE (USP-RS)
PHENOTHIAZINE [USP-RS]
Fenothiazine [Dutch]
Fenotiazina [Italian]
Thiodifenylamine [Dutch]
Phenothiazine,C12H9NS,92-84-2
Thiodiphenylamin [German]
Tiodifenilamina [Italian]
CAS-92-84-2
Phenothiazine [INN:NF]
ALIMEMAZINE HEMITARTRATE IMPURITY C (EP IMPURITY)
ALIMEMAZINE HEMITARTRATE IMPURITY C [EP IMPURITY]
PROMETHAZINE HYDROCHLORIDE IMPURITY A (EP IMPURITY)
PROMETHAZINE HYDROCHLORIDE IMPURITY A [EP IMPURITY]
Contraverm
a phenothiazine
2,3:5,6-Dibenzo-1,4-thiazine
Nemazine (veterinary)
Phenothiazine (Standard)
Phenothiazine, >=98%
Opera_ID_1719
PHENOTHIAZINE [MI]
cid_7108
SCHEMBL9114
PHENOTHIAZINE [HSDB]
Nemazine [veterinary] (TN)
Oprea1_495637
MLS001424182
MLS002152928
MLS003166904
BIDD:GT0831
PHENOTHIAZINE [WHO-DD]
Phenothiazine, SAJ first grade
SCHEMBL2395921
CHEBI:37932
CHEBI:38093
HY-Y0055R
WLN: T C666 BM ISJ
NSC2037
HMS1607G06
HMS2052I13
HMS2230N12
HMS3372C18
HMS3394I13
HMS3652J21
HMS3715J12
HMS3885P13
Pharmakon1600-01506171
PHENOTHIAZINE [GREEN BOOK]
HY-Y0055
Tox21_111090
Tox21_400010
BBL011728
BDBM50012855
NSC760392
s4251
STK205834
AKOS000119180
Tox21_111090_1
CCG-101115
DB11447
FD53774
NC00365
NSC-760392
PS-3980
PHENOTHIAZINE, REFERENCE STANDARD
NCGC00091146-01
NCGC00091146-03
NCGC00091146-05
NCGC00091146-08
Phenothiazine, purum, >=98.0% (GC)
AC-10429
BP-31210
DA-76809
SY004343
CS-0008338
NS00002986
P0106
SW197745-2
EN300-19084
Phenothiazine, Vetec(TM) reagent grade, 98%
D02601
F90393
AB00572590_12
Phenothiazine, VETRANAL(TM), analytical standard
Q410846
SR-01000721844
SR-01000721844-3
SR-01000721844-4
BRD-K59597909-001-17-6
BRD-K59597909-001-19-2
BRD-K59597909-001-20-0
F0266-2850
Z104472694
Phenothiazine, United States Pharmacopeia (USP) Reference Standard
202-196-5
75788-67-9
InChI=1/C12H9NS/c1-3-7-11-9(5-1)13-10-6-2-4-8-12(10)14-11/h1-8,13