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Corticosterone

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Identification
Molecular formula
C21H30O4
CAS number
50-22-6
IUPAC name
(10S,13R,14S,17R)-14-hydroxy-13-methyl-3-oxo-17-(6-oxopyran-3-yl)-2,6,7,8,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde
State
State

At room temperature, corticosterone is a solid. It is stable under normal conditions and should be stored in a cool, dry place.

Melting point (Celsius)
182.00
Melting point (Kelvin)
455.15
Boiling point (Celsius)
487.90
Boiling point (Kelvin)
761.05
General information
Molecular weight
346.46g/mol
Molar mass
346.4580g/mol
Density
1.2800g/cm3
Appearence

Corticosterone is typically a white, odorless, crystalline powder. It may have a very slight off-white or yellowish tint due to impurities when not in pure form.

Comment on solubility

Solubility of (10S,13R,14S,17R)-14-hydroxy-13-methyl-3-oxo-17-(6-oxopyran-3-yl)-2,6,7,8,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde

This compound, with a complex structure, presents unique challenges and considerations regarding its solubility. Solubility is influenced by various factors, including molecular structure, polarity, and the presence of functional groups. Here are some key points to consider:

  • Polarity: The compound features multiple functional groups such as hydroxyl (–OH) and carbonyl (C=O) groups, which typically enhance solubility in polar solvents.
  • Hydrophobic Regions: The extensive hydrocarbon portion of the molecule suggests significant hydrophobic characteristics, indicating potential solubility issues in highly polar solvents like water.
  • Solvent Compatibility: It is likely to show better solubility in organic solvents, such as ethanol, methanol, or acetone, which can interact favorably with both the polar and non-polar parts of the molecule.
  • Concentration and Temperature: Increased concentration and adjustment of temperature may further influence solubility, as many compounds exhibit improved solubility at elevated temperatures.

In summary, while the (10S,13R,14S,17R)-14-hydroxy-13-methyl-3-oxo-17-(6-oxopyran-3-yl)-2,6,7,8,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde is expected to have variable solubility profiles depending on the solvent used, its complex architecture necessitates careful consideration of solvent choice to achieve effective dissolution.

Interesting facts

Interesting Facts About (10S,13R,14S,17R)-14-hydroxy-13-methyl-3-oxo-17-(6-oxopyran-3-yl)-2,6,7,8,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde

This complex organic compound is a significant member of the steroidal family, showcasing a rich structural diversity that is a hallmark of natural products. It features multiple hydroxy and carbonyl functional groups that contribute to its chemical reactivity and biological activity.

Key Characteristics:

  • Stereochemistry: The specific stereochemistry indicated by the (S,R) configurations at various positions plays a crucial role in defining its biological function and interaction with biological macromolecules.
  • Possibility of Biological Activity: Compounds of this nature often serve as biologically active molecules, with potential roles in medicinal chemistry and drug development.
  • Structural Complexity: The intricate cyclopenta[a]phenanthrene framework suggests the compound may be derived from natural sources, particularly in the field of phytochemistry.
  • Reading the Code: Understanding the detailed nomenclature (e.g., “14-hydroxy”, “13-methyl”) requires a solid grasp of organic chemistry principles and a familiarity with IUPAC naming conventions.

As a student or researcher in the field of chemistry, you may find it fascinating to explore the synthetic pathways that lead to the production of such compounds. One quote that resonates deeply in this context is: "Chemistry is the craft of the molecular world, where every twist and turn can lead to groundbreaking discoveries."
The potential applications of this compound may range from pharmaceuticals to agricultural enhancements, showcasing the vast landscape of chemistry in today’s world.

In conclusion, the study of compounds like this one not only enhances our understanding of chemical structures and properties but also opens doors to innovative applications that can benefit society.