Erythromycin | Solubility of Things

Identification

Molecular formula

C₃₇H₆₇NO₁₃

CAS number

114-07-8

IUPAC name

[(10S,13S,14S,16R)-10,12,13,14,16,23-hexahydroxy-6,10,19-trimethyl-24-oxa-4-azaheptacyclo[12.12.0.02,11.04,9.015,25.018,23.019,25]hexacosan-22-yl] acetate

State

Erythromycin is typically a solid at room temperature, appearing as a crystalline powder.

Melting point (Celsius)

135.00

Melting point (Kelvin)

408.15

Boiling point (Celsius)

514.00

Boiling point (Kelvin)

787.15

General information

Molecular weight

733.94g/mol

Molar mass

733.9380g/mol

Density

1.2400g/cm³

Appearence

Erythromycin appears as a white or slightly yellow crystalline powder. It is often found in its dihydrate form and is odorless.

Comment on solubility

Solubility of [(10S,13S,14S,16R)-10,12,13,14,16,23-hexahydroxy-6,10,19-trimethyl-24-oxa-4-azaheptacyclo[12.12.0.02,11.04,9.015,25.018,23.019,25]hexacosan-22-yl] acetate

The solubility of the complex molecule [(10S,13S,14S,16R)-10,12,13,14,16,23-hexahydroxy-6,10,19-trimethyl-24-oxa-4-azaheptacyclo[12.12.0.02,11.04,9.015,25.018,23.019,25]hexacosan-22-yl] acetate can be influenced by various factors due to its intricate structure. Here are several key points to consider:

Hydroxyl Groups: The presence of multiple hydroxyl (-OH) groups typically increases hydrophilicity, suggesting that this compound may have enhanced solubility in water and polar solvents.
Acetic Acid Moiety: The acetate group can contribute to solubility, particularly in polar solvents, as it can form hydrogen bonds.
Overall Structure: The heptacyclic nature of the compound could hinder solubility due to steric factors, which might limit how well it interacts with solvent molecules.

In summary, while the multiple hydroxyl groups and acetate moiety suggest potential for solubility in polar solvents, the complex structural characteristics might counteract this effect, leading to variable solubility depending on the specific conditions. As is often stated in the field, "the structure of a molecule is a key determinant of its solubility." Therefore, further empirical studies would be necessary to accurately assess the solubility of this intriguing compound.

Interesting facts

Interesting Facts About [acetate of (10S,13S,14S,16R)-10,12,13,14,16,23-hexahydroxy-6,10,19-trimethyl-24-oxa-4-azaheptacyclo[12.12.0.02,11.04,9.015,25.018,23.019,25]hexacosan-22-yl]

This compound, with its complex name, belongs to a fascinating category of chemical substances known as polyhydroxylated compounds. These types of compounds often exhibit interesting biological properties and have garnered attention in fields such as pharmacology and biochemistry.

Here are some notable aspects of this particular compound:

Structural Complexity: The compound features an intricate framework, characterized by multiple hydroxyl (-OH) groups along with an aza and oxa bridge. This complexity often contributes to unique reactivity patterns and interactions with biological systems.
Potential Biological Activity: Due to its multiple hydroxyl groups, it may function in a manner akin to carbohydrates, engaging in hydrogen bonding and potentially influencing biological activity. Such compounds are often explored for their roles in drug design.
Applications in Drug Development: Compounds like this can serve as lead structures for creating pharmaceuticals. Their unique properties might aid in the development of drugs targeting a variety of conditions, including those related to metabolic disorders.
Natural Occurrence: The structural configuration suggests that it could be related to natural products, which are often sources of inspiration for synthetic chemists. Understanding how nature synthesizes such compounds can guide synthetic strategies.

As chemists delve deeper into the world of complex organic structures, compounds like this one not only challenge our synthetic capabilities but also open new avenues for research in medicinal chemistry and biological applications. The study of such compounds emphasizes the beauty and intricacy of chemical science, reminding us that each molecule carries a story waiting to be uncovered.