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Lurasidone

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Identification
Molecular formula
C28H36F3N3O2S
CAS number
367514-88-3
IUPAC name
11-[3-(4-methylpiperazin-1-yl)propyl]-6-(trifluoromethyl)-6H-thiochromeno[4,3-b]indole
State
State

At room temperature, lurasidone is typically found in a solid state.

Melting point (Celsius)
184.00
Melting point (Kelvin)
457.15
Boiling point (Celsius)
771.00
Boiling point (Kelvin)
1 044.15
General information
Molecular weight
492.68g/mol
Molar mass
492.6100g/mol
Density
1.5000g/cm3
Appearence

Lurasidone appears as a white to off-white crystalline solid.

Comment on solubility

Solubility of 11-[3-(4-methylpiperazin-1-yl)propyl]-6-(trifluoromethyl)-6H-thiochromeno[4,3-b]indole

The solubility characteristics of 11-[3-(4-methylpiperazin-1-yl)propyl]-6-(trifluoromethyl)-6H-thiochromeno[4,3-b]indole can be quite intriguing due to its complex structure. Understanding solubility is essential for various applications, including formulation and pharmacokinetics. Here are some key points to consider regarding this compound’s solubility:

  • Polarity: The presence of polar functional groups due to the amine structure of the piperazine may enhance solubility in polar solvents.
  • Hydrophobic Interactions: The trifluoromethyl group contributes hydrophobic characteristics, which might limit solubility in water.
  • Solvent Compatibility: This compound may exhibit solubility in organic solvents such as DMSO or methanol due to its overall composition.
  • Temperature Dependence: Solubility could be affected by temperature; it is often observed that higher temperatures increase solubility for solid materials.
  • pH Influence: The solubility in aqueous solutions can vary with pH, especially if ionic forms can be generated or neutralized.

As the saying goes, "Like dissolves like," a principle that highlights the importance of matching solvents with the polarity of the solute. Thus, practical assessment of this compound’s solubility typically requires experimentation under varying conditions to determine the optimal solvent and concentration for application.

Interesting facts

Interesting Facts about 11-[3-(4-methylpiperazin-1-yl)propyl]-6-(trifluoromethyl)-6H-thiochromeno[4,3-b]indole

This fascinating compound stands out for its complex structure and potential applications in medicinal chemistry. Known for its intricate arrangement, the compound is a member of the thiochromeno class, which is pertinent in the development of various pharmaceuticals.

Here are some intriguing aspects of this compound:

  • Structural Diversity: The combination of a thiochromene framework with a trifluoromethyl group and a piperazine substituent generates a highly unique chemical structure that could offer diverse reactivity and interactions.
  • Trifluoromethyl Group: The presence of the trifluoromethyl moiety is significant. It is known for enhancing the bioavailability and lipophilicity of compounds, which can lead to improved pharmacological properties.
  • Piperazine Ring: The 4-methylpiperazin-1-yl element is often associated with various pharmacological activities, including anxiolytic and antidepressant effects. This suggests potential therapeutic applications for our compound.
  • Research Interest: Thiochromeno compounds are being explored for their roles in treating neurological disorders and certain types of cancer, making this compound a key area of research.
  • Versatile Synthesis: The synthetic routes to produce this compound may offer chemists an opportunity to explore different reaction conditions and catalysts, thus contributing to the field of synthetic organic chemistry.

This compound's synthesis and study are not just about understanding individual properties; they could lead to the discovery of new classes of drugs that could have significant impacts on health. In the words of a renowned chemist, "Every compound holds a story; it’s up to us to discover and understand it."

With ongoing research and exploration, the full potential of 11-[3-(4-methylpiperazin-1-yl)propyl]-6-(trifluoromethyl)-6H-thiochromeno[4,3-b]indole is still unfolding!