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Zotepine Hydrochloride

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Identification
Molecular formula
C24H23F3N2OS·2HCl
CAS number
108620-01-5
IUPAC name
11-[3-(4-methylpiperazin-1-yl)propyl]-6-(trifluoromethyl)-6H-thiochromeno[4,3-b]indole;dihydrochloride
State
State

At room temperature, zotepine hydrochloride is typically found in a solid crystalline form. It is designed for stability as a solid, particularly for use in pharmaceuticals.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
398.20
Boiling point (Kelvin)
671.35
General information
Molecular weight
429.52g/mol
Molar mass
429.5200g/mol
Density
1.3700g/cm3
Appearence

Zotepine hydrochloride appears as a white to slightly yellowish-white crystalline powder. It is an antipsychotic medication, typically provided in a solid form suitable for oral or injectable administration. The compound is hygroscopic, meaning it has the ability to absorb moisture from the air.

Comment on solubility

Solubility of 11-[3-(4-methylpiperazin-1-yl)propyl]-6-(trifluoromethyl)-6H-thiochromeno[4,3-b]indole; dihydrochloride

The solubility of the compound 11-[3-(4-methylpiperazin-1-yl)propyl]-6-(trifluoromethyl)-6H-thiochromeno[4,3-b]indole; dihydrochloride is influenced by its unique structural characteristics and functional groups. Here are several key points regarding its solubility:

  • Polar and Ionic Characteristics: The presence of two hydrochloride groups typically enhances the solubility in polar solvents such as water.
  • Hydrophobic Elements: The thiochromeno structure and trifluoromethyl group introduce hydrophobic characteristics, possibly reducing solubility in aqueous environments.
  • Solvent Interaction: Solubility may vary significantly with different solvents; the compound is expected to have better solubility in alcohols, dimethyl sulfoxide (DMSO), or other organic solvents due to hydrophobic interactions.
  • pH Dependence: The solubility profile can change with pH levels; acidic conditions may enhance solubility due to the ionization of the hydrochloride moieties.

In summary, while the dihydrochloride form promises an increased solubility in polar environments, the hydrophobic features of the compound may limit solubility in pure water. This compound’s solubility can be best characterized as moderately soluble in polar solvents with particular solubility behavior in organic matrices.

Interesting facts

Interesting Facts about 11-[3-(4-methylpiperazin-1-yl)propyl]-6-(trifluoromethyl)-6H-thiochromeno[4,3-b]indole; dihydrochloride

This compound is a fascinating example of modern medicinal chemistry, primarily due to its potential as a therapeutic agent. The structural complexity of this compound highlights the innovative approaches in drug design aimed at targeting specific biological receptors. Here are some interesting aspects:

  • Structural Features: The presence of a thiochromeno moiety combined with a trifluoromethyl group suggests interesting electronic properties, which can significantly affect the compound's interactions with biological targets.
  • Potential Applications: Research indicates that derivatives of this compound may exhibit activity in treating various conditions, including neurological disorders and cancer, showcasing the transformative nature of chemical synthesis.
  • Mechanism of Action: Compounds like this one are often designed to interact with neurotransmitter systems, and their unique configurations can enhance selectivity for specific receptors, potentially leading to fewer side effects compared to traditional therapies.
  • Pharmacophore Development: The combination of the piperazine and indole substructures provides a versatile framework for developing new pharmacophores, which can be fine-tuned to optimize efficacy and minimize toxicity.
  • Research Significance: As studies continue to unveil the biological activity of such compounds, they serve as vital tools for understanding the complex interactions within biological systems. "Every new compound discovered is a piece of the puzzle in understanding life itself."

In summary, the exploration of 11-[3-(4-methylpiperazin-1-yl)propyl]-6-(trifluoromethyl)-6H-thiochromeno[4,3-b]indole; dihydrochloride not only reveals the intricacies of drug design but also emphasizes the importance of interdisciplinary collaboration in the fields of chemistry, biology, and medicine.

Synonyms
29465-22-3
(1)Benzothiopyrano(4,3-b)indole, 6,11-dihydro-11-(3-(4-methyl-1-piperazinyl)propyl)-7(or 9)-(trifluoromethyl)-, dihydrochloride
RefChem:203910
DTXSID30951975
11-[3-(4-Methylpiperazin-1-yl)propyl]-6-(trifluoromethyl)-6,11-dihydro[1]benzothiopyrano[4,3-b]indole--hydrogen chloride (1/2)