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Clobazam

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Identification
Molecular formula
C16H13ClN2O
CAS number
22316-47-8
IUPAC name
11-[3-(dimethylamino)propyl]-5H-benzo[b][1,4]benzodiazepin-6-one
State
State

Clobazam is typically encountered in its solid form at room temperature.

Melting point (Celsius)
178.00
Melting point (Kelvin)
451.15
Boiling point (Celsius)
502.15
Boiling point (Kelvin)
775.30
General information
Molecular weight
300.75g/mol
Molar mass
300.7490g/mol
Density
1.2800g/cm3
Appearence

Clobazam is a white or almost white crystalline powder.

Comment on solubility

Solubility of 11-[3-(dimethylamino)propyl]-5H-benzo[b][1,4]benzodiazepin-6-one

The solubility of 11-[3-(dimethylamino)propyl]-5H-benzo[b][1,4]benzodiazepin-6-one in various solvents can be quite nuanced due to its specific molecular structure. Understanding its solubility behavior is crucial for applications in pharmacology and drug formulation.

Factors Influencing Solubility

Several factors can significantly influence the solubility of this compound:

  • Polarity: The presence of the dimethylamino group imparts some polar characteristics, which may enhance solubility in polar solvents.
  • Hydrophobic Interactions: The large aromatic rings contribute to hydrophobicity, possibly leading to reduced solubility in water.
  • pH Levels: Changes in pH can affect the ionization of the amino group, which may alter solubility in aqueous solutions.

Expected Solubility Behavior

It can be expected that:

  • The compound may be sparingly soluble in water, primarily dissolving better in organic solvents such as ethanol or dimethyl sulfoxide (DMSO).
  • In acidic or basic conditions, solubility may improve due to the ionization of the amino group.
  • Solubility may also exhibit a temperature dependency, generally increasing with higher temperatures.

In concluding remarks, assessing solubility behavior is essential for effective utilization in pharmacological applications, highlighting the need for careful consideration of the solvent environment to optimize dissolution and bioavailability.

Interesting facts

Interesting Facts about 11-[3-(dimethylamino)propyl]-5H-benzo[b][1,4]benzodiazepin-6-one

This fascinating compound belongs to the class of benzodiazepines, which are known for their psychoactive properties. Benzodiazepines are widely recognized for their utility in medical applications, particularly in treating anxiety, insomnia, and certain seizure disorders. Here are some intriguing insights into this specific compound:

  • Psychoactive Properties: Benzodiazepines, including this compound, interact with the central nervous system by enhancing the effects of the neurotransmitter GABA (gamma-aminobutyric acid), leading to sedation, muscle relaxation, and anticonvulsant effects.
  • Structure and Function: The unique structure of this compound comprises a benzo[b][1,4]benzodiazepine core which contributes to its biological activity. The presence of the dimethylamino group can influence its pharmacological profile.
  • Research Potential: Due to its structural characteristics, researchers are interested in this compound for exploring new therapies. Its ability to modify neurotransmission makes it a candidate for further investigation in treating various neuropsychiatric conditions.
  • Safety and Regulation: Like many benzodiazepines, this compound would be subject to strict regulatory controls due to its potential for dependence and abuse. Understanding the balance between efficacy and safety is crucial in medicinal chemistry.

As a student of chemistry, one might find it particularly enlightening to study the synthesis routes and functionalization possibilities of such compounds. The exploration of benzodiazepine derivatives can reveal invaluable insights into drug design and development, connecting theoretical chemistry with practical applications in pharmacology.

In the words of Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This sentiment rings true as we examine the myriad of possibilities that compounds like 11-[3-(dimethylamino)propyl]-5H-benzo[b][1,4]benzodiazepin-6-one present in the realms of drug discovery and therapeutic innovation.

Synonyms
13450-72-1
U 17660
5-(3-(Dimethylamino)propyl)-5,10-dihydro-11H-dibenzo(b,e)(1,4)diazepin-11-one
DTXSID80158755
U-17660
U 17,660
U-17,660
5-[3-(Dimethylamino)propyl]-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one
DTXCID2081246
11-[3-(dimethylamino)propyl]-5H-benzo[b][1,4]benzodiazepin-6-one
CHEMBL29330
11H-DIBENZO(b,e)(1,4)DIAZEPIN-11-ONE, 5,10-DIHYDRO-5-(3-(DIMETHYLAMINO)PROPYL)-
BRN 0758508
SUKRRJYMPHOCIP-UHFFFAOYSA-N
BDBM50226900
CI-579
11H-Dibenzo[b,e][1,4]diazepin-11-one, 5-[3-(dimethylamino)propyl]-5,10-dihydro-