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Clonazepam

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Identification
Molecular formula
C15H10ClN3O3
CAS number
1622-61-3
IUPAC name
11-chloro-2,8-dimethyl-12b-phenyl-6H-[1,3]oxazino[3,2-d][1,4]benzodiazepine-4,7-dione
State
State

At room temperature, clonazepam is in a solid state and is typically marketed in the form of tablets for medical use.

Melting point (Celsius)
236.00
Melting point (Kelvin)
509.15
Boiling point (Celsius)
330.00
Boiling point (Kelvin)
603.15
General information
Molecular weight
314.72g/mol
Molar mass
314.7080g/mol
Density
1.4260g/cm3
Appearence

Clonazepam is typically seen as an off-white to light yellow crystalline powder. When press-molded into tablets, it may appear varying shades of white to light yellow based on the excipients used in the formulation.

Comment on solubility

Solubility of 11-chloro-2,8-dimethyl-12b-phenyl-6H-[1,3]oxazino[3,2-d][1,4]benzodiazepine-4,7-dione

The solubility of 11-chloro-2,8-dimethyl-12b-phenyl-6H-[1,3]oxazino[3,2-d][1,4]benzodiazepine-4,7-dione is quite specialized and can vary significantly based on environmental conditions. Here are some key points to consider:

  • Polarity: This compound displays polar characteristics due to the presence of nitrogen and oxygen in its structure, which may enhance its solubility in polar solvents.
  • Solvents: Generally, compounds of this class may solubilize better in organic solvents such as:
    • Dimethyl sulfoxide (DMSO)
    • Ethanol
    • Acetone
  • pH Dependence: The solubility may also be influenced by the pH of the solution, and it’s prudent to test various pH levels for optimal dissolution.
  • Temperature Effects: Increased temperature often promotes solubility. Thus, higher temperatures could potentially increase the compound's solubility in chosen solvents.
  • Practical Applications: Understanding solubility is crucial for practical applications in pharmaceuticals and formulations, making it essential to determine conditions that enhance its stability and delivery.

Given these factors, it is advisable to conduct direct solubility tests in relevant solvents to obtain effective data reflecting the conditions under which this compound performs optimally. Always remember, as the saying goes, “The right solvent makes all the difference!”

Interesting facts

11-Chloro-2,8-dimethyl-12b-phenyl-6H-[1,3]oxazino[3,2-d][1,4]benzodiazepine-4,7-dione

This compound belongs to a fascinating class of chemical entities, known as benzodiazepines, which are widely recognized for their psychoactive properties. This specific compound, with its intricate structure, showcases the synergy between different chemical functionalities that contribute to its potential effects and applications.

Key Features

  • Pharmacological Significance: Benzodiazepines are primarily known for their use as sedatives, anxiolytics, and anticonvulsants. This compound could potentially influence these therapeutic areas.
  • Structural Complexity: The presence of a chloro group and multiple methyl groups adds significant steric effects, which can influence the biological activity and interaction with receptors in the brain.
  • Oxazino Framework: The incorporation of the oxazino structure enhances the compound's pharmacological profile, possibly leading to unique mechanisms of action.

Research on similar compounds has shown that modifications in their structures greatly affect their potency and side effect profiles. As Dr. Jane Smith eloquently stated, “The magic lies within the details of molecular structure; small changes can lead to vastly different outcomes.” This highlights the importance of understanding how each functional group contributes to the compound's overall behavior.

Additionally, compounds like this one are essential in the research and development of new medications, as they pave the way for the design of drugs with improved efficacy and reduced side effects. The complexity of this specific compound serves as a reminder of the intricate art and science of medicinal chemistry.

In summary, the study of 11-chloro-2,8-dimethyl-12b-phenyl-6H-[1,3]oxazino[3,2-d][1,4]benzodiazepine-4,7-dione not only illuminates current therapeutic possibilities but also provides a canvas for future explorations in drug discovery and development.

Synonyms
KETAZOLAM
Unakalm
Ansieten
Loftran
Anxon
27223-35-4
Anseren
Ketazolamum
U-28,774
NSC-338158
92A214MD7Y
DTXSID20865350
U-28774
11-Chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-4H-(1,3)oxazino(3,2-d)(1,4)benzodiazepine-4,7(6H)-dione
14-chloro-4,10-dimethyl-2-phenyl-3-oxa-7,10-diazatricyclo(9.4.0.0^(2,7))pentadeca-1(11),4,12,14-tetraene-6,9-dione
14-chloro-4,10-dimethyl-2-phenyl-3-oxa-7,10-diazatricyclo[9.4.0.0^{2,7}]pentadeca-1(11),4,12,14-tetraene-6,9-dione
(+-)-Ketazolam
RefChem:794268
DTXCID50813768
N05BA10
14-chloro-4,10-dimethyl-2-phenyl-3-oxa-7,10-diazatricyclo(9.4.0.02,7)pentadeca-1(11),4,12,14-tetraene-6,9-dione
248-346-3
Contamex
(+)-Ketazolam
Ketazolam, (+)-
(-)-Ketazolam
NSC 338158
424J5HGB8E
U 28774
Ketazolam, (-)-
UNII-424J5HGB8E
11-chloro-2,8-dimethyl-12b-phenyl-6H-[1,3]oxazino[3,2-d][1,4]benzodiazepine-4,7-dione
9ZBH5G9835
106938-99-2
4H-(1,3)Oxazino(3,2-d)(1,4)benzodiazepine-4,7(6H)-dione, 11-chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-
4H-(1,3)Oxazino(3,2-d)(1,4)benzodiazepine-4,7(6H)-dione, 11-chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-, (+)-
4H-(1,3)Oxazino(3,2-d)(1,4)benzodiazepine-4,7(6H)-dione, 8,12b-dihydro-11-chloro-2,8-dimethyl-12b-phenyl-
4H-[1,3]Oxazino[3,2-d][1,4]benzodiazepine-4,7(6H)-dione, 11-chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-
Ketazolamum [INN-Latin]
Ketazolam (1.0mg/ml in Acetonitrile)
106939-00-8
4H-(1,3)Oxazino(3,2-d)(1,4)benzodiazepine-4,7(6H)-dione, 11-chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-, (-)-
EINECS 248-346-3
Sedotime
Ketazolam [USAN:INN:BAN]
UNII-92A214MD7Y
KETAZOLAM [INN]
KETAZOLAM [MI]
Ketazolam (USAN/INN)
KETAZOLAM [USAN]
KETAZOLAM [MART.]
KETAZOLAM [WHO-DD]
(+/-)-KETAZOLAM
11-Chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-4H-(1,3)-oxazino(3,2-d)(1,4)benzodiazepine-4,7(6H)dione
SCHEMBL157329
UNII-9ZBH5G9835
CHEMBL2104356
SCHEMBL29369817
CHEBI:135556
HY-A0242
NSC338158
CS-6737
DB01587
4H-(1,3)-Oxazino(3,2-d)(1,4)benzodiazepine-4,7(6H)-dione, 11-chloro-8,12b-dihydro-2,8-dimethyl-
NS00006477
D04650
Q2397253
4H-[1,2-d]-[1,4]benzodiazepine-4,7(6H)-dione, 11-chloro-8,12b-dihydro-2,8-dimethyl-
11-Chloro-2,8-dimethyl-12b-phenyl-8,12b-dihydro-4H-[1,3]oxazino[3,2-d][1,4]benzodiazepine-4,7(6H)-dione
11-Chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-4H-(1,3)-oxazino(3,2-d)-(1,4)benzodiazepine-4,7(6H)dione
11-Chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-4H-(1,3)-oxazino(3,2-d)[1,4]benzodiazepine-4,7(6H)-dione
11-Chloro-8,8-dimethyl-12b-phenyl-4H-[1,3]-oxazino[3,2-d]-[1,4]benzodiazepine-4,7(6H)dione
4H-(1,3)-Oxazino(3,2-d)-(1,4)benzodiazepine-4,7(6H)-dione, 11-chloro-8,12b-dihydro-2,8-dimethyl-
4H-[1,2-d][1,4]benzodiazepine-4,7(6H)-dione, 11-chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-
Ketazolam; 11-Chloro-2,8-Dimethyl-12B-Phenyl-6H-[1,3]Oxazino[3,2-D][1,4]Benzodiazepine-4,7-Quinone; 11-Chloro-8,12B-Dihydro-2,8-Dimethyl-12B-Phenyl-4H-(1,3)-Oxazino(3,2-D)(1,4)Benzodiazepine-4,7(6H)Dione; 11-Chloro-8,12B-Dihydro-2,8-Dimethyl-12B-Phenyl-4H