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Nitrofurantoin

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Identification
Molecular formula
C8H10N4O5
CAS number
67-20-9
IUPAC name
1,1-diethyl-3-[(5-nitro-2-furyl)methyleneamino]isothiourea
State
State

At room temperature, nitrofurantoin is typically in a solid state as a crystalline powder.

Melting point (Celsius)
272.00
Melting point (Kelvin)
545.15
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.15
General information
Molecular weight
238.20g/mol
Molar mass
238.2170g/mol
Density
1.6740g/cm3
Appearence

Nitrofurantoin appears as a yellow to orange crystalline powder. It is known for its bright coloring and crystalline texture.

Comment on solubility

Solubility of 1,1-Diethyl-3-[(5-Nitro-2-Furyl)methyleneamino]isothiourea

The solubility of 1,1-diethyl-3-[(5-nitro-2-furyl)methyleneamino]isothiourea can be quite intriguing due to its unique chemical structure. Understanding its solubility is essential for various applications in chemistry and pharmacology.

In general, the solubility of a compound is influenced by several factors, including:

  • Polarity: Compounds with polar functional groups tend to be more soluble in polar solvents, such as water.
  • Hydrogen Bonding: The ability to form hydrogen bonds can enhance solubility; however, steric hindrance in bulky groups may limit this interaction.
  • Temperature: Higher temperatures often increase solubility, as the heat provides energy to overcome solute-solvent interactions.

For 1,1-diethyl-3-[(5-nitro-2-furyl)methyleneamino]isothiourea, one might anticipate:

  • Its nitro and isothiourea moieties might contribute to some degree of polar character, making it more soluble in organic solvents.
  • However, the presence of the ether and aromatic ring could reduce solubility in aqueous solutions.

To conclude, while theoretical perspectives provide valuable insights, experimental data on solubility is crucial to confirm the behavior of this compound in various solvents. As the saying goes, "Solubility is a journey, not a destination," highlighting the complexity and importance of this property in chemical research.

Interesting facts

Interesting Facts about 1,1-Diethyl-3-[(5-nitro-2-furyl)methyleneamino]isothiourea

1,1-Diethyl-3-[(5-nitro-2-furyl)methyleneamino]isothiourea is a fascinating compound that showcases the versatility and complexity of nitrogen-containing chemicals. This compound falls under the category of isothioureas, which are known for their wide range of biological activities and applications.

Here are some noteworthy aspects of this intriguing compound:

  • Biological Activity: Isothioureas are often studied for their potential therapeutic effects. Research indicates that compounds containing isothiourea moieties can exhibit antimicrobial, antitumor, and anti-inflammatory properties, making them key candidates in medicinal chemistry.
  • Structure-Activity Relationship: The unique arrangement of the 5-nitro-2-furyl group in this compound highlights the significance of structural modifications. Such variations can profoundly influence the biological activity and chemical stability of the molecule.
  • Mechanism of Action: Compounds like this one may work through various mechanisms. The presence of the nitro group is known to participate in redox reactions, possibly affecting cellular pathways and leading to anticancer activity.
  • Research Interest: As a compound with potential applications, researchers are keenly interested in this isothiourea. Studies often explore its efficacy in different biological assays and its interactions with various biological targets.
  • Synthetic Utility: The synthesis of this compound may involve multi-step organic reactions, providing a valuable example for chemistry students learning about nitrogen chemistry and complex organic synthesis.

The study of 1,1-diethyl-3-[(5-nitro-2-furyl)methyleneamino]isothiourea not only emphasizes the importance of chemical diversity but also opens doors for future research in the fields of pharmacology and organic synthesis. As noted by chemists, "The exploration of chemical compounds can lead to unexpected breakthroughs in medicine and science."

Overall, this compound represents a small yet vital piece of the larger puzzle in understanding the applications of organic compounds in the modern world.