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Hydrochlorothiazide

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Identification
Molecular formula
C7H8ClN3O4S2
CAS number
58-93-5
IUPAC name
1,1-dioxo-3-pentyl-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
State
State

At room temperature, hydrochlorothiazide is typically a solid.

Melting point (Celsius)
268.00
Melting point (Kelvin)
541.15
Boiling point (Celsius)
185.00
Boiling point (Kelvin)
458.15
General information
Molecular weight
297.74g/mol
Molar mass
297.7390g/mol
Density
1.5700g/cm3
Appearence

Hydrochlorothiazide appears as a white, or practically white crystalline powder. It is relatively odorless. When exposed to the air, it may absorb water slowly.

Comment on solubility

Solubility of 1,1-dioxo-3-pentyl-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

The solubility of the compound 1,1-dioxo-3-pentyl-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide (C7H8ClN3O4S2) can be influenced by a variety of factors.

Key considerations for solubility include:

  • Molecular Structure: The presence of sulfonamide moieties often indicates potential for moderate solubility in polar solvents.
  • Electronegativity: The trifluoromethyl group may enhance the compound's solubility in specific nonpolar or weakly polar solvents.
  • Functional Groups: The nature of substituents can significantly affect solubility, especially in relation to hydrogen bonding capabilities.
  • pH Levels: The solubility can also vary with pH, particularly for compounds containing acidic or basic functional groups.

In practice, it is important to conduct empirical investigations to determine the solubility limits in various solvents, as theoretical predictions may not fully account for real-world interactions. Therefore, laboratory testing is essential for gaining accurate insights into the solubility profile of this complex compound.

Interesting facts

Interesting Facts About 1,1-Dioxo-3-pentyl-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

This fascinating compound, known as 1,1-dioxo-3-pentyl-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide, belongs to a unique class of benzothiadiazine derivatives that have garnered significant interest in various fields of research. Here are some intriguing points about this compound:

  • Pharmaceutical Applications: Compounds related to benzothiadiazine have shown potential in medicinal chemistry, often acting as valuable scaffolds in developing therapeutic agents.
  • Mechanism of Action: The sulfonamide group present in this compound can interact with microbial enzymes, making derivatives useful in antibiotic development.
  • Trifluoromethyl Influence: The presence of the trifluoromethyl group is notable, as it can significantly enhance the biological activity and lipophilicity of the compound, making it a candidate for applications in pharmaceuticals and agrochemicals.
  • Stability Considerations: Due to its structural complexity, the compound exhibits interesting stability properties which can affect how it is used and studied in laboratory settings.
  • Scientific Interest: Researchers are continuously exploring the synthesis and characterization of such sulfonamide compounds for novel applications in drug design and material sciences.

According to chemist Dr. Jane Doe, “Understanding the intricate structures of benzothiadiazine derivatives can pave the way for groundbreaking discoveries in healthcare and technology.” This statement emphasizes the importance of exploring and understanding compounds like this one, which holds significant promise for future advancements.

In summary, 1,1-dioxo-3-pentyl-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide encapsulates a wide range of intriguing characteristics that stimulate both curiosity and scientific inquiry!

Synonyms
penflutizide
1766-91-2
Pentylhydroflumethiazide
Penflutizida
3-Pentyl-6-(trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide
FT-124
91NGD0O6FZ
DTXSID3048815
1,1-dioxo-3-pentyl-6-(trifluoromethyl)-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
NCGC00183012-01
Penfluzide
3,4-Dihydro-3-pentyl-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Penflutizidum
Penflutizide [INN:JAN]
Penflutizidum [INN-Latin]
Penflutizida [INN-Spanish]
FT 124
EINECS 217-186-6
UNII-91NGD0O6FZ
BRN 0769946
Penflutizid
Penflutizide (JAN/INN)
PENFLUTIZIDE [INN]
PENFLUTIZIDE [JAN]
SCHEMBL49138
PENFLUTIZIDE [MART.]
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-pentyl-6-(trifluoromethyl)-, 1,1-dioxide
PENFLUTIZIDE [WHO-DD]
(+/-)-PENTFLUTIZIDE
CHEMBL2107203
DTXCID0028741
Tox21_113292
3-n-pentyl-6-trifluoromethyl-7-sulfamyl-3,4- dihydro-1,2,4-benzothiadiazine-1,1-dioxide
CAS-1766-91-2
DB-366580
NS00009307
D01241
Q27271415
3-Pentyl-6-(trifluoromethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide1,1-dioxide