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Dorzolamide

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Identification
Molecular formula
C10H16F3N5O4S2
CAS number
120279-96-1
IUPAC name
1,1-dioxo-6-(trifluoromethyl)-4H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
State
State

At room temperature, dorzolamide is generally a solid, especially when not in its commercial aqueous solution form, which is usually liquid and used for ophthalmic purposes.

Melting point (Celsius)
133.50
Melting point (Kelvin)
406.60
Boiling point (Celsius)
94.50
Boiling point (Kelvin)
367.70
General information
Molecular weight
324.11g/mol
Molar mass
324.1120g/mol
Density
1.4640g/cm3
Appearence

Dorzolamide is a white to off-white, crystalline powder that is often used in ophthalmic solutions. It is generally odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 1,1-Dioxo-6-(trifluoromethyl)-4H-1λ6,2,4-benzothiadiazine-7-sulfonamide

The solubility of 1,1-dioxo-6-(trifluoromethyl)-4H-1λ6,2,4-benzothiadiazine-7-sulfonamide in various solvents can be intriguing due to its unique molecular structure. Here are some key points regarding its solubility:

  • Polar Solvents: This compound tends to show limited solubility in polar solvents, largely due to its bulkiness and the presence of trifluoromethyl groups that can cause steric hindrance.
  • Non-Polar Solvents: It may exhibit better solubility in non-polar solvents, as the hydrophobic characteristics associated with the trifluoromethyl group can facilitate interaction.
  • pH Dependence: The solubility can also be influenced by the pH of the solvent, which can affect the protonation state of the sulfonamide group, potentially enhancing solubility in certain conditions.
  • Temperature Influence: Generally, solubility may increase with temperature, but specific data for this compound would need to be acknowledged for accurate insight.

In summary, while the solubility of this compound varies significantly with the choice of solvent and environmental conditions, it remains relatively elusive in terms of achieving high solubility in common polar solvents. Understanding these factors is critical for applications involving this intriguing chemical.

Interesting facts

Interesting Facts about 1,1-Dioxo-6-(trifluoromethyl)-4H-1λ6,2,4-benzothiadiazine-7-sulfonamide

This intriguing compound is a member of the benzothiadiazine family, known for its unique structural features and versatile applications in various fields. Here are some fascinating points to note:

  • Biological Activity: Compounds within this class have been investigated for their potential pharmacological properties, particularly as diuretics and antihypertensives, which make them essential in medicinal chemistry.
  • Trifluoromethyl Group: The presence of a trifluoromethyl group significantly enhances the compound's lipophilicity, granting it unique interactions with biological systems and affecting its activity.
  • Environmental Impact: The sulfonamide moiety is noted for its role in developing environmentally friendly agricultural chemicals, reducing the ecological footprint associated with conventional pesticides.
  • Versatile Reactivity: This compound exhibits a rich array of reactivity, making it a valuable building block for synthesizing further complex organic molecules in chemical research.

In the realm of drug discovery, the structural insights derived from compounds like 1,1-dioxo-6-(trifluoromethyl)-4H-1λ6,2,4-benzothiadiazine-7-sulfonamide pave the way for innovation. As chemists continue to investigate its properties, this compound remains a testament to the intricate connections between molecular structure and biological function.

In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." This resonates particularly true in the study of such multifaceted compounds, where each discovery can lead to new possibilities.

Synonyms
FLUMETHIAZIDE
Ademol
148-56-1
Trifluoromethylthiazide
Flumethiazid
Flumetiazid
Fludemil
Routrax
Ademil
Flumetiazida
Trifluomethylthiazide
Flumethazide
Flumethiazidum
Flumetiazide
Flumetiazide [DCIT]
NSC 44626
Flumethiazide [INN:BAN]
Flumethiazidum [INN-Latin]
Flumetiazida [INN-Spanish]
Trifluoromethyl thiazide
HSDB 2845
UNII-3PA0CDS0M5
EINECS 205-717-4
3PA0CDS0M5
NSC-44626
Ademol (TN)
Flumethiazide (INN)
FLUMETHIAZIDE [MI]
FLUMETHIAZIDE [INN]
FLUMETHIAZIDE [HSDB]
6-(Trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
FLUMETHIAZIDE [VANDF]
4H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide
FLUMETHIAZIDE [WHO-DD]
6-Trifluoromethyl-7-sulfamyl-1,2,4-benzothiadiazine 1,1-dioxide
6-Trifluoromethyl-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
DTXSID60163862
6-Trifluoromethyl-7-sulfamoyl-4H-1,2,4-benzothiadiazine 1,1-dioxide
6-Trifluoromethyl-7-sulfamoyl-4H-1,4,2-benzothiadiazine 1,1-dioxide
7-Sulfamoyl-6-trifluoromethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
6-(Trifluoromethyl)-1,2,4-benzo-thiadiazine-7-sulfonamide 1,1-dioxide
6-(Trifluoromethyl)-1,4,2-benzothiadiazine-7-sulfonamido 1,1-dioxide
1,1-dioxo-6-(trifluoromethyl)-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide
Flumethiazidum (INN-Latin)
Flumetiazida (INN-Spanish)
1,1-dioxo-6-(trifluoromethyl)-4H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
SCHEMBL26534
CHEMBL2105128
DTXCID4086353
CHEBI:135404
NSC44626
2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-(trifluoromethyl)-, 1,1-dioxide
AKOS040751820
WLN: T66 BSWM ENJ HXFFF ISZW
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide (8CI)
NS00041520
D02453
Q27257858
6-Trifluoromethyl-7-sulfamyl-1,4-benzothiadiazine 1,1-dioxide
6-(Trifluoromethyl)-1,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-(Trifluoromethyl)-1,4-benzothiadiazine-7-sulfonamido 1,1-dioxide
6-Trifluoromethyl-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide
6-Trifluoromethyl-7-sulfamoyl-4H-1,4-benzothiadiazine 1,1-dioxide
7-Sulfamoyl-6-trifluoromethyl-2H-1,4-benzothiadiazine 1,1-dioxide
2H-1,4-Benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide
4H-1,4-Benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide (8CI)(9CI)
10,10-dioxo-4-(trifluoromethyl)-10-lamda6-thia-7,9-diazabicyclo(4.4.0)deca-2,4,8,11-tetraene-3-sulfonamide
205-717-4