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Etoposide

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Identification
Molecular formula
C29H32O13N
CAS number
33419-42-0
IUPAC name
(11-ethyl-8,9-dihydroxy-4,6,16,18-tetramethoxy-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-13-yl) 2-(3-methyl-2,5-dioxo-pyrrolidin-1-yl)benzoate
State
State

Etoposide is typically found as a solid at room temperature.

Melting point (Celsius)
242.00
Melting point (Kelvin)
515.15
Boiling point (Celsius)
760.00
Boiling point (Kelvin)
1 033.15
General information
Molecular weight
588.56g/mol
Molar mass
588.5630g/mol
Density
1.4500g/cm3
Appearence

Etoposide appears as a white to yellowish crystalline powder. It is practically insoluble in water, soluble in dichloromethane, and sparingly soluble in ethanol.

Comment on solubility

Solubility Characteristics

The solubility of the compound (11-ethyl-8,9-dihydroxy-4,6,16,18-tetramethoxy-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-13-yl) 2-(3-methyl-2,5-dioxo-pyrrolidin-1-yl)benzoate (C29H32O13N) is an intricate aspect that greatly influences its applications and behavior in various environments. Understanding its solubility can be broken down into key factors:

Factors Affecting Solubility

  • Polar vs. Nonpolar: The presence of multiple -OH (hydroxyl) groups suggests that this compound may exhibit some degree of water solubility due to hydrogen bonding.
  • Size and Complexity: The large and complex structure may hinder complete solubility, especially in nonpolar solvents.
  • Functional Groups: The presence of functional groups like methoxy (-OCH3) and the azo group can introduce polarity, enhancing solubility in organic solvents.

As a result, the compound is likely to be:

  • Slightly soluble in water, due to the polar nature of hydroxyl groups.
  • More soluble in organic solvents like ethanol or acetone, where its complex structure can be more effectively accommodated.

In summary, while the solubility of this particular compound may vary depending on the solvent, its unique structural features suggest a nuanced interaction with both polar and nonpolar environments.

Interesting facts

Interesting Facts about (11-ethyl-8,9-dihydroxy-4,6,16,18-tetramethoxy-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-13-yl) 2-(3-methyl-2,5-dioxo-pyrrolidin-1-yl)benzoate

This compound, often referred to in scientific circles for its complex structure, serves as a fascinating example in the realm of organic chemistry. Here are some intriguing facts about this unique molecule:

  • Complexity: The compound features a highly intricate framework characterized by the 11-aza configuration and multiple methoxy groups. This complexity not only makes synthesis challenging but also enhances its potential applications.
  • Applications: Due to its unique structure, this compound could have implications in medicinal chemistry. The presence of medicinally relevant functional groups suggests potential biological activity, paving the way for future pharmaceutical research.
  • Synthesis Challenges: The preparation of this compound may involve advanced synthetic techniques. Chemists often employ strategies such as total synthesis or combinatorial chemistry, which require a deep understanding of reaction mechanisms.
  • Interdisciplinary Nature: Its synthesis and study span across various fields, including medicinal chemistry, natural product chemistry, and structural biology, highlighting the interdisciplinary nature of modern chemistry.
  • Structural Insights: The compound's structural configuration allows for interesting conformation variations, which can significantly influence its reactivity and interactions with biological targets.

As noted by experts in the field, "Understanding the intricate details of such compounds can unlock new pathways in drug development and material sciences." This highlights the importance of continued research into complex organic molecules.

Overall, this compound not only showcases the beauty of organic synthesis but also invites chemists to explore its deeper implications in science and industry.