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Dexamethasone

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Identification
Molecular formula
C22H29FO5
CAS number
50-02-2
IUPAC name
[11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] pentanoate
State
State

At room temperature, dexamethasone is typically in a solid state as a crystalline powder.

Melting point (Celsius)
262.00
Melting point (Kelvin)
535.15
Boiling point (Celsius)
570.00
Boiling point (Kelvin)
843.15
General information
Molecular weight
392.47g/mol
Molar mass
392.4660g/mol
Density
1.3000g/cm3
Appearence

Dexamethasone appears as a white to practically white, odorless, crystalline powder. It is a synthetic corticosteroid with potent anti-inflammatory properties.

Comment on solubility

Solubility of [11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl] pentanoate

The solubility of this compound is dependent on several factors, including its structural intricacies and the presence of functional groups. Here are some key points to consider:

  • Polarity: The presence of hydroxyl groups in the structure indicates that the compound may exhibit polar characteristics, potentially enhancing solubility in polar solvents such as water.
  • Hydrophobic regions: The compound also contains a hydrophobic hydrocarbon skeleton, which can limit its solubility in polar media while promoting solubility in organic solvents.
  • Functional groups: The dual presence of hydroxy and carboxylic functionalities suggests the possibility of hydrogen bonding, which can facilitate solubility in certain solvents.
  • Chain Length: With a pentanoate group, the aliphatic tail can further influence solubility, potentially affecting interactions with various solvents.

In summary, while this compound may be moderately soluble in polar solvents due to its hydroxyl groups, its hydrophobic components feasibly restrict solubility in highly polar environments. Therefore, “the solubility profile” can be complex and must be evaluated within the context of a suitable solvent system.


Interesting facts

Interesting Facts about 11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl pentanoate

This intriguing compound belongs to a larger class of molecules commonly known as steroids, which play crucial roles in various biological systems. Below are some fascinating insights into this complex structure:

  • Medicinal Potential: Steroid compounds often exhibit significant pharmacological properties. This particular compound may hold promise for therapeutic applications, including hormone replacement therapy and anti-inflammatory treatments.
  • Structural Complexity: The molecular architecture features multiple functional groups, specifically hydroxyl and acetyl groups, which contribute to its biological activity and interaction potential with biological receptors.
  • Biological Significance: Compounds of this nature are often investigated for their ability to modulate metabolic processes. Researchers explore their roles in endocrinology, particularly in the synthesis of sex hormones.
  • Research Opportunities: The unique arrangement of methyl and oxo groups in the steroid framework invites extensive research into its mechanism of action at the molecular level, potentially leading to the discovery of new biochemical pathways.

"Chemistry isn't just about reactions; it's about understanding how these reactions manifest in the living world." This quote resonates with the study of compounds like this one, highlighting the necessity for scientists to explore and deepen their understanding of complex molecular interactions.

Overall, the study of 11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl pentanoate not only enriches our knowledge of steroids but also opens the doors to innovative medical solutions. Its multifaceted characteristics and potential applications make it a captivating subject within the realm of organic chemistry and drug discovery.

Synonyms
11,21-dihydroxy-3,20-dioxopregna-1,4-dien-17-yl pentanoate
SCHEMBL25388
DTXSID10871965
QAA18000
[(8S,9R,10R,11S,13S,14S,17R)-11-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[A