Skip to main content

Dexamethasone

ADVERTISEMENT
Identification
Molecular formula
C22H29FO5
CAS number
50-02-2
IUPAC name
11-hydroxy-7-(1-hydroxy-1-methyl-ethyl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.02,11.05,10.016,24.017,22]tetracosa-9,16(24),17,19,21-pentaen-8-one
State
State

At room temperature, dexamethasone is a solid. It is typically found in pharmaceutical preparations in tablet or injectable form.

Melting point (Celsius)
262.00
Melting point (Kelvin)
535.00
Boiling point (Celsius)
438.00
Boiling point (Kelvin)
711.00
General information
Molecular weight
392.47g/mol
Molar mass
392.4700g/mol
Density
1.3000g/cm3
Appearence

Dexamethasone is typically a white to off-white, crystalline powder. It can appear as fine needles or a granular powder, depending on the method of crystallization.

Comment on solubility

Solubility of 11-hydroxy-7-(1-hydroxy-1-methyl-ethyl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.02,11.05,10.016,24.017,22]tetracosa-9,16(24),17,19,21-pentaen-8-one (C22H29FO5)

The solubility of this compound can be quite intriguing due to its complex structural features and functional groups. Generally, the solubility behavior of organic compounds is influenced by several factors:

  • Polarity: The presence of hydroxyl (–OH) groups suggests a degree of polarity which typically enhances solubility in polar solvents, such as water.
  • Hydrophobic Interactions: The large hydrocarbon portions of the molecule might limit solubility in highly polar environments, indicating possible increased solubility in organic solvents like ethanol or dimethyl sulfoxide (DMSO).
  • Hydrogen Bonding: The hydroxyl groups can engage in hydrogen bonding, potentially increasing the solubility in water compared to non-polar solvents.
  • Molecular Size: The larger the molecular size, often the lower the solubility due to spatial constraints.

In summary, while some aspects of the compound suggest a predilection for solubility in polar solvents, the extensive hydrocarbon structure must also be considered. Therefore, it is reasonable to expect that:

  • Solubility in water: Likely limited but possibly enhanced by concentration and temperature.
  • Solubility in organic solvents: More favorable, especially in solvents that can accommodate large molecules.

Understanding the solubility profile of this compound requires a comprehensive analysis factoring in these diverse attributes.

Interesting facts

Interesting Facts about 11-hydroxy-7-(1-hydroxy-1-methyl-ethyl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.02,11.05,10.016,24.017,22]tetracosa-9,16(24),17,19,21-pentaen-8-one

This compound, with its intricate structure, is a fascinating example of complexity in organic chemistry. The presence of multiple functional groups and the unusual arrangement of cyclic structures highlight the beauty and diversity of molecular configurations. Here are some intriguing aspects worth noting:

  • Synthetic Potential: Given its complex architecture, this compound may serve as a valuable precursor in the synthesis of biologically active molecules. The presence of a hydroxyl group can significantly influence reactivity and solubility.
  • Natural Occurrence: Compounds with similar structural motifs are often found in naturally occurring alkaloids and phytochemicals, suggesting that this compound may have biological relevance or analogs in nature.
  • Pharmacological Interactions: The presence of nitrogen and oxygen heteroatoms indicates that this compound could potentially exhibit interesting pharmacological properties, making it a candidate for further biological evaluation.
  • Cyclic Framework: The hexacyclic structure exemplifies the sophisticated way in which molecules can be constructed, showing how nature often favors intricate arrangements to achieve stability and functionality.
  • Research Implications: Exploring this compound could uncover new pathways for drug development, considering that many drugs are designed from complex organic molecules similar to this one.

In conclusion, 11-hydroxy-7-(1-hydroxy-1-methyl-ethyl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.02,11.05,10.016,24.017,22]tetracosa-9,16(24),17,19,21-pentaen-8-one stands as a testament to the intricacies of organic chemistry, reflecting both the creative potential of chemists and the secrets that nature holds in its molecular labyrinth.

Synonyms
paxillin
2H-1-BENZOPYRANO[5',6':6,7]INDENO[1,2-B]INDOL-3(4BH)-ONE, 5,6,6A,7,12,12B,12C,13,14,14A-DECAHYDRO-4B-HYDROXY-2-(1-HYDROXY-1-METHYLETHYL)-12B,12C-DIMETHYL-, (2R,4BS,6AS,12BS,12CR,14AS)-
4b-Hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one
11-hydroxy-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.02,11.05,10.016,24.017,22]tetracosa-9,16(24),17,19,21-pentaen-8-one
Compound NP-024130
GTPL2309
BDBM86263
ACNHBCIZLNNLRS-UHFFFAOYSA-N
11-hydroxy-7-(2-hydroxypropan-2-yl)-1,2-dimethyl-6-oxa-23-azahexacyclo[12.10.0.0^{2,11}.0^{5,10}.0^{16,24}.0^{17,22}]tetracosa-9,16(24),17,19,21-pentaen-8-one
AKOS040737282
BS-1489
NCGC00168476-01
CAS_57186-25-1
DB-053014
hydroxy-(1-hydroxy-1-methyl-ethyl)-dimethyl-[?]one
2H-1-Benzopyrano(5',6':6,7)indeno(1,2-b)indol-3(4bH)-one, 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, (2-.alpha.,4b-.beta.,6a-.alpha.,12b-.beta.,12c-.alpha.,14a-.beta.)-
2H-1-Benzopyrano[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one, 5,6,6a,7,12,12b,12c,13,14,14a-decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-, [2R-(2.alpha.,4b.beta.,6a.alpha.,12b.beta.,12c.alpha.,14a.beta.)]-
4b-Hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bh)-one #