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1,1,1-Trifluoropropan-2-ol

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Identification
Molecular formula
C3H5F3O
CAS number
460-39-3
IUPAC name
1,1,1-trifluoropropan-2-ol
State
State

1,1,1-Trifluoropropan-2-ol is typically found in a liquid state at room temperature. It has a moderate level of solubility in water and can mix with many organic solvents due to its alcohol group.

Melting point (Celsius)
-11.00
Melting point (Kelvin)
262.15
Boiling point (Celsius)
82.00
Boiling point (Kelvin)
355.15
General information
Molecular weight
114.07g/mol
Molar mass
114.0710g/mol
Density
1.2960g/cm3
Appearence

1,1,1-Trifluoropropan-2-ol is a clear liquid with a pungent odor. It is a fluorinated alcohol, and its chemical structure is characterized by the presence of three fluorine atoms and a hydroxyl group attached to the carbon backbone.

Comment on solubility

Solubility of 1,1,1-trifluoropropan-2-ol

1,1,1-trifluoropropan-2-ol exhibits notable solubility characteristics due to its unique molecular structure. The presence of fluorine atoms significantly affects its interactions with solvents. Here are some key points regarding its solubility:

  • Polar Nature: The three fluorine atoms impart a strong polar character to the molecule, enhancing its ability to dissolve in polar solvents.
  • Alcohol Functionality: As an alcohol, 1,1,1-trifluoropropan-2-ol contains a hydroxyl (-OH) group that can form hydrogen bonds, further increasing its solubility in water.
  • Miscibility: It is well-miscible in water, indicating that it can readily dissolve when mixed with this solvent.
  • Solvent Interaction: The compound may show varying solubility in organic solvents, with higher solubility in polar solvents like ethanol or methanol compared to non-polar solvents.

In summary, the solubility behavior of 1,1,1-trifluoropropan-2-ol is largely governed by its polar characteristics and ability to participate in hydrogen bonding. This polar alcohol is particularly soluble in water and polar organic solvents, making it versatile for various applications.

Interesting facts

Interesting Facts about 1,1,1-Trifluoropropan-2-ol

1,1,1-Trifluoropropan-2-ol, also known as a fluorinated alcohol, is a fascinating compound in the field of organic chemistry due to its unique structural and chemical properties. Below are some compelling aspects of this compound:

  • Fluorination Effect: The presence of three fluorine atoms significantly alters the behavior of this alcohol compared to its non-fluorinated analogs. Fluorine enhances the acidity of the hydroxyl group, leading to interesting reactivity in different chemical reactions.
  • Applications in Industry: This compound is utilized in various applications, including as a solvent and as an intermediate in the synthesis of other complex fluorinated compounds, aiding the creation of high-performance materials.
  • Role in Pharmaceuticals: Due to its distinctive properties, 1,1,1-trifluoropropan-2-ol can serve as a building block in the synthesis of pharmaceutical agents, potentially enhancing drug properties like stability and bioavailability.
  • Green Chemistry: The design and use of fluorinated compounds like this one are often explored in green chemistry to achieve safer and more sustainable processes, minimizing environmental impact.

As highlighted by renowned chemists, "Fluorinated compounds unlock new pathways in both organic synthesis and materials science." Thus, 1,1,1-trifluoropropan-2-ol continues to be a compound of interest in ongoing chemical research and development activities.

In summary, 1,1,1-trifluoropropan-2-ol is not just another alcohol; its unique properties and applications make it a noteworthy subject for study and exploration in various chemistry fields.

Synonyms
374-01-6
1,1,1-TRIFLUORO-2-PROPANOL
1,1,1-Trifluoropropan-2-ol
2-Propanol, 1,1,1-trifluoro-
1,1,1-trifluoro-propan-2-ol
1,1,1-Trifluoroisopropanol
1-Methyl-2,2,2-trifluoroethanol
NSC 3637
EINECS 206-773-2
MFCD00014403
DTXSID20870520
17556-48-8
(S)-1,1,1-Trifluoropropanol
1,1,1-Trifluoropropanol-2
MFCD06797331
NSC3637
starbld0018401
1,1,1Trifluoro2propanol
1,1,1Trifluoropropan2ol
1,1-Trifluoro-2-propanol
SCHEMBL5841
2-Propanol,1,1-trifluoro-
1Methyl2,2,2trifluoroethanol
1-Methyl-2,2-trifluoroethanol
1,1,1,-trifluoro-2-propanol
DTXCID90818237
VDLBMMCEQLNVJT-UHFFFAOYSA-N
BCP15883
BCP31759
NSC-3637
rac-1,1,1,-trifluoro-2-propanol
rac-1,1,1-trifluoro-propan-2-ol
(rac)-1,1,1-Trifluoro-2-propanol
(rac)-1,1,1-trifluoro-propan-2-ol
1,1,1-Trifluoro-2-propanol, 97%
AKOS004904114
FT79597
SB17912
SB36890
(2S)-2-Hydroxy-1,1,1-trifluoropropane
AS-47304
SY024147
SY261367
SY262173
DB-001168
NS00041750
EN300-95274
F13188
InChI=1/C3H5F3O/c1-2(7)3(4,5)6/h2,7H,1H
206-773-2