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Cortisol

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Identification
Molecular formula
C21H30O5
CAS number
50-23-7
IUPAC name
11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
State
State

At room temperature, cortisol is typically a solid. It is stable under normal conditions and exhibits crystalline properties that allow it to be powdered or pressed into tablets for pharmaceutical use.

Melting point (Celsius)
218.00
Melting point (Kelvin)
491.15
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.15
General information
Molecular weight
362.46g/mol
Molar mass
362.4600g/mol
Density
1.3070g/cm3
Appearence

Cortisol is a white to off-white crystalline powder. It can also appear as a colorless crystalline substance when purified. The compound is typically found in its glucocorticoid form in pharmaceuticals, demonstrating typical crystalline characteristics such as well-defined edges and a glossy or matte surface depending on how it crystallizes.

Comment on solubility

Solubility of 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

The compound with the chemical formula C21H30O5 exhibits specific solubility characteristics that are influenced by its complex structure. Generally, the solubility of such organic compounds can be systematized as follows:

  • Polar solvents: The presence of hydroxyl groups (-OH) in the structure suggests that the compound may exhibit increased solubility in polar solvents, such as water and alcohols, due to hydrogen bonding capabilities.
  • Nonpolar solvents: Conversely, the hydrophobic regions of the molecule hint at possible solubility in nonpolar solvents like hexane or chloroform, although this would likely be less pronounced than in polar solvents.
  • Temperature effects: Solubility might also vary with temperature; increasing temperature can enhance solubility in most cases, especially for organic compounds like this one.

In essence, this compound could be described as having a dual characteristic in solubility, being more soluble in polar environments while retaining some solubility in nonpolar settings. The specific ratios and interactions between the functional groups will dictate the overall solubility behavior under varying conditions. Always consider performing empirical tests to confirm solubility trends found in theoretical evaluations.

Interesting facts

Interesting Facts about 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one

This fascinating compound, known for its complex structure, falls within the realm of steroids, specifically a subclass of natural or synthetic derivatives with unique pharmacological properties. Here are some intriguing aspects:

  • Biological Significance: This compound displays potential biological activities that may include anti-inflammatory and antioxidant effects, making it a subject of interest in pharmaceutical research.
  • Synthesis: The challenging synthesis of such compounds often requires intricate multi-step processes, illustrating the creativity and innovation in organic chemistry. Novel synthetic routes can lead to improved yield and efficiency.
  • Structural Highlights: With multiple hydroxy groups, this compound showcases the diversity in functional groups that can profoundly affect reactivity and solubility, underlying the importance of structural design in drug development.
  • Applications: Its derivatives are studied for potential therapeutic applications in various diseases, especially in hormone-related conditions due to their steroid-like mechanism of action.
  • Research Trends: Ongoing research into similar compounds is pushing the boundaries of medicinal chemistry, exploring their roles in cancer therapy and metabolic disorders.

In the words of renowned chemist Linus Pauling, "The best way to have a good idea is to have a lot of ideas." This compound exemplifies this philosophy, as its design and interaction with biological systems gather insights that could lead to groundbreaking medical advancements.

Overall, the study of 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one opens doors to discussions about the intricate dance of chemistry and biology, revealing the potential for new discoveries in therapeutics.

Synonyms
11,17,21-Trihydroxypregn-4-ene-3,20-dione
MLS001074333
1,10-dihydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
73565-87-4
CHEMBL1730629
SCHEMBL12737556
CHEBI:95202
HMS2230P20
HMS3369A04
(8S,9S,10R,11R,13S,14S,17R)-11,17-Dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
79037-25-5
ALBB-025803
BBL033643
STL372840
AKOS005058485
SMR000674616
VS-12198
EU-0099955
4-Pregnene-11ss,17a,21-triol-3,20-dione
EN300-296082
SR-01000214153
pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-
SR-01000214153-1
Q27167016
11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one