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Cortodexon

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Identification
Molecular formula
C22H30O5
CAS number
53-06-5
IUPAC name
11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
State
State
The compound exists as a solid at room temperature, maintaining its integrity as a white crystalline powder. It is generally odorless and has significant stability under normal conditions of temperature and pressure.
Melting point (Celsius)
221.00
Melting point (Kelvin)
494.15
Boiling point (Celsius)
528.30
Boiling point (Kelvin)
801.45
General information
Molecular weight
404.50g/mol
Molar mass
404.4990g/mol
Density
1.2600g/cm3
Appearence

Cortodexon typically appears as a white crystalline powder. It is known for its structural stability and typically maintains its form under standard conditions without deliquescing.

Comment on solubility

Solubility of 11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one (C22H30O5)

The solubility of 11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one in various solvents can be influenced by several factors due to its complex structure. This compound incorporates multiple functional groups, indicating that its solubility characteristics are likely to vary significantly between polar and nonpolar environments.

Factors Affecting Solubility:

  • Polarity: The presence of hydroxyl groups enhances its affinity for polar solvents such as water and ethanol, suggesting possible moderate solubility.
  • Hydrophobic Characteristics: The significant hydrophobic portions of the molecule, derived from its cyclopenta[a]phenanthrene core, might limit solubility in highly polar solvents.
  • Temperature: As with many organic compounds, solubility may increase with temperature, which is a critical factor during experiments.
  • pH Influence: The pH can also affect the ionization of hydroxyl groups and their interactions with solvents, thus impacting solubility.

In summary, while this compound is expected to exhibit a degree of solubility in polar solvents, the balance of hydrophilic and hydrophobic interactions makes its overall solubility complex. Researchers would be wise to conduct specific solubility tests in varied solvents to explore its behavior fully.

Interesting facts

Interesting Facts About 11,17-Dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

This compound, known for its complex structure and unique functional groups, is remarkable for several reasons:

  • Natural Origins: Compounds similar in structure to this one are often found in natural products. They can be derived from plant sources, reflecting the rich chemistry present in nature.
  • Biological Activity: The presence of multiple hydroxyl groups in its structure suggests potential pharmacological properties. These functional groups are important in interacting with biological systems, often contributing to the compound’s reactivity and solubility.
  • Structure-Activity Relationship: Understanding how the various substituents on this compound influence its activity can be a fascinating area of study. The modifications of the hydroxyl and carbonyl groups can lead to changes in the compound's behavior within biological contexts, which is essential for drug development.
  • Synthetic Challenges: The synthesis of such intricate compounds often presents significant challenges to chemists. Strategies utilizing advanced organic synthesis techniques are often required to navigate the complexity of the molecule.
  • Applications: Due to its structure, this compound may have applications in the fields of medicinal chemistry and biochemistry. Its ability to serve as a precursor or intermediate in the synthesis of other functionalized compounds is noteworthy.

As chemists explore this compound, they find that each synthesis and modification tells a story about the compound's potential and the challenges involved in achieving it. Not only does it contribute to our understanding of chemical principles, but it also opens doors to future innovations in the pharmaceutical sciences.

Synonyms
A-Methapred
6-.alpha.-Methylprednisolone
MEPRDL
Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-6-methyl-, (6.alpha.,11.beta.)-
MLS002638721
Prednisolone, 6.alpha.-methyl-
Urbazone
M-Prednisol
.DELTA.1-6.alpha.-Methylhydrocortisone
6a-methylprednisolone
6a_Methylprednisolone
U 7532
11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
SCHEMBL541256
CHEMBL190259
VHRSUDSXCMQTMA-UHFFFAOYSA-N
HMS3086J15
STL372918
AKOS024386987
11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
SMR001496976
.delta.(sup 1)-6-.alpha.-Methylhydrocortisone
1,4-Pregnadiene-3,20-dione, 11beta,17alpha,21-trihydroxy-6alpha-methyl-
11-.beta.,17,21-Trihydroxy-6-.alpha.-methylpregna-1,4-diene-3,20-dione
(6.alpha.,11.beta.)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione, (6.alpha.,11.beta.)- #
11-.beta.,17-.alpha.,21-Trihydroxy-6-.alpha.-methyl-1,4-pregnadiene-3,20-dione
Pregna-1,4-diene-3,20-dione, 11.beta.,17,21-trihydroxy-6.alpha.-methyl-
Pregna-1,4-diene-3,20-dione, 6.alpha.-methyl-11.beta.-17,21-trihydroxy-