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Galanthamine

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Identification
Molecular formula
C17H21NO3
CAS number
357-70-0
IUPAC name
(11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-4,6,7,11b-tetrahydro-1H-benzo[a]quinolizine
State
State

Solid at room temperature.

Melting point (Celsius)
124.00
Melting point (Kelvin)
397.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
287.35g/mol
Molar mass
287.3530g/mol
Density
1.3333g/cm3
Appearence

Galanthamine is a white, crystalline alkaloid.

Comment on solubility

Solubility of (11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-4,6,7,11b-tetrahydro-1H-benzo[a]quinolizine

The solubility of complex organic compounds like (11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-4,6,7,11b-tetrahydro-1H-benzo[a]quinolizine can significantly influence their usability in various chemical applications. Several factors govern its solubility, including:

  • Molecular Structure: The presence of specific functional groups such as methoxy groups can enhance solubility in polar solvents.
  • Polarity: A compound's overall polarity affects its interaction with solvents, where similar polarities lead to better solubility.
  • Temperature: Increased temperatures often lead to higher solubility for many organic compounds due to increased kinetic energy.
  • pH Level: The solubility can also vary with pH, particularly for compounds that can ionize in solution.

This compound is likely to exhibit varying solubility profiles in different solvents. As a general observation:

  • In polar solvents (like water and alcohols): Enhanced solubility due to potential hydrogen bonding with the methoxy and other polar sites.
  • In non-polar solvents (like hexane): Lower solubility due to lack of interaction with the predominantly hydrophobic regions of the molecule.

To conclude, understanding the solubility of (11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-4,6,7,11b-tetrahydro-1H-benzo[a]quinolizine is critical for its application in pharmaceutical and chemical industries, highlighting the intricate balance between molecular properties and solubility behavior.

Interesting facts

Interesting Facts about (11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-4,6,7,11b-tetrahydro-1H-benzo[a]quinolizine

This complex organic compound is a fascinating example of how intricate chemical structures can influence biological activity. Here are some interesting points about it:

  • Structural Complexity: The compound features multiple rings and functional groups, showcasing the complexity often found in natural products and pharmaceuticals.
  • Potential Biological Activities: Compounds with a similar structure are studied in medicinal chemistry for their potential therapeutic properties, including anti-cancer and anti-inflammatory effects.
  • Chirality: The presence of chiral centers in the structure leads to enantiomers that could exhibit different biological activity, making stereochemistry a crucial area of study.
  • Source of Inspiration: Researchers often draw inspiration from naturally occurring alkaloids, which share similar core structures to this compound, opening avenues for drug development.

As a chemistry student, you might find it intriguing to explore how modifications to the compound's structure can lead to variations in its efficacy and safety profile. This compound exists at the intersection of synthetic and organic chemistry, illustrating how chemists can manipulate molecular structure to create compounds with desired properties. The exploration of such compounds not only enhances our understanding of molecular interactions but also pushes the boundaries of what can be achieved in medicinal chemistry.

In the words of chemist Robert H. Grubbs: "Innovations in chemistry come from recognizing patterns, creating new compounds, and discovering how their unique properties can impact our world."


Synonyms
Dehydroemetine
4914-30-1
Dehidroemetina
Mebadin
2-Dehydroemetine
Dehydroemetinum
(-)-2,3-Dehydroemetine
BT 436
(11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-4,6,7,11b-tetrahydro-1H-benzo[a]quinolizine
Ro 1-9334/19
Dehydroemetine, (+/-)-
(+/-)-2,3-Dehydroemetine
1986-67-0
2,3-Didehydro-6',7',10,11-tetramethoxyemetan
NSC-131546
2,3-Didehydroemetine
CHEBI:4363
L36LY97UH4
4H-Benzo[a]quinolizine,3-ethyl-1,6,7,11b-tetrahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-, (11bS)-
Emetine, 2,3-didehydro-
7S79QT1T91
Ro 1-9334
2,3-Dehydroemetine
3-Ethyl-9,10-dimethoxy-1,6,7,11b-tetrahydro-2-((1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolyl)methyl)-4H-benzo(a)quinolizine
Dehydroemetine (INN)
Ro-1933419
Emetine, 2,3-dehydro-, (-)-
DEHYDROEMETINE [INN]
4H-Benzo(a)quinolizine, 3-ethyl-1,6,7,11b-tetrahydro-9,10-dimethoxy-2-(((1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl)methyl)-, (11bs)-rel-
Emetan, 2,3-didehydro-6',7',10,11-tetramethoxy-
Dehydroemetinum [INN-Latin]
Dehidroemetina [INN-Spanish]
CCRIS 4110
Dehydroemetine [INN:BAN:DCF]
NSC-129414
EINECS 225-542-7
NSC 131546
UNII-L36LY97UH4
UNII-7S79QT1T91
Mebadin (TN)
Ro 1-9334/20
Emetine,3-didehydro-
Didehydro-6',7',10,11-tetramethoxyemetane
DEHYDROEMETINE [MI]
Emetane, didehydro-6',7',10,11-tetramethoxy-
SCHEMBL66089
Emetine,3-dehydro-, (-)-
DEHYDROEMETINE [WHO-DD]
CHEMBL1697741
CHEBI:149634
XXLZPUYGHQWHRN-RPBOFIJWSA-N
DTXSID901023600
NSC131546
AKOS040741621
DB13865
26266-12-6
MS-28899
NCI60_000664
HY-121241
CS-0081294
NS00045215
C07996
D00828
G13052
RO-1-9334/19
Emetan,3-didehydro-6',7',10,11-tetramethoxy-
Q5252386
SR-02000000202-1
(11BS)-3-ETHYL-1,6,7,11B-TETRAHYDRO-9,10-DIMETHOXY-2-(((1R)-1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-1-ISOQUINOLINYL)METHYL)-4H-BENZO(A)QUINOLIZINE
121523-30-6
4H-BENZO(A)QUINOLIZINE, 3-ETHYL-1,6,7,11B-TETRAHYDRO-9,10-DIMETHOXY-2-(((1R)-1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-1-ISOQUINOLINYL)METHYL)-, (11BS)-