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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
(11S,17S)-11,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
State
State

Estradiol is in a solid state at room temperature. It is specifically found as a crystalline powder, which indicates stability and low reactivity under normal conditions.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
570.15
Boiling point (Kelvin)
843.15
General information
Molecular weight
272.38g/mol
Molar mass
272.3810g/mol
Density
1.1690g/cm3
Appearence

Estradiol typically appears as a white or almost white crystalline powder. It is odorless and is an organic compound. The powder form is crystalline, indicating that the molecules are organized in a highly ordered microscopic structure, forming a crystal lattice that extends in all directions.

Comment on solubility

Solubility of (11S,17S)-11,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

The solubility of organic compounds such as (11S,17S)-11,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol can be complex and is influenced by various factors. Generally, the solubility behavior can be described by the following principles:

  • Polarity: The degree of polarity plays a crucial role in solubility. Non-polar compounds are typically soluble in non-polar solvents, while polar compounds are better dissolved in polar solvents.
  • Functional Groups: The presence of hydroxyl (-OH) groups, as in this compound, often enhances solubility in water due to hydrogen bonding.
  • Molecular Size: Larger molecules may experience limitations in solubility due to their size and structure, affecting their intermolecular interactions.
  • Temperature: Solubility can increase with temperature; thus, higher temperatures may help dissolve compounds that are initially insoluble at room temperature.

In assessing the solubility of (11S,17S)-11,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol, one might find that its large hydrocarbon structure may limit its solubility in water, while it could be more soluble in organic solvents such as ethanol or acetone. However, it's essential to experimentally determine solubility in various solvents for precise applications.

In conclusion, the solubility of this compound can be deemed moderate to low in aqueous solutions but may vary significantly in non-polar organic solvents due to its unique structural features.

Interesting facts

Exploring (11S,17S)-11,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

(11S,17S)-11,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol is a fascinating compound belonging to a class of organic molecules known as steroids. Its unique structure and characteristics have garnered significant interest in various fields, particularly in medicinal chemistry and pharmacology.

Key Characteristics:

  • Stereochemistry: This compound possesses specific stereosignatures at the 11th and 17th positions, which are vital in determining its biological activity.
  • Biological Relevance: Compounds like these often serve as precursors or intermediates in the synthesis of hormones and other biologically active substances.
  • Structural Complexity: The intricate arrangement of carbon and functional groups in this molecule makes it a subject of study for organic synthesis techniques.

In the realm of research, scientists are continuously exploring the potential of such complex compounds to unlock new therapeutic strategies. As exemplified by the saying, "Structure determines function," understanding the precise molecular architecture of (11S,17S)-11,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol may lead to significant advancements in drug design.

The study of this compound also opens doors to discussions about:

  1. The implications of stereochemistry in pharmacodynamics and pharmacokinetics.
  2. Innovative synthesis methods that can produce this compound efficiently.
  3. Its potential derivatives and modifications that might enhance biological activity or reduce side effects.

Not only does this compound exemplify the beauty of complex organic chemistry, but it also highlights the intricate relationship between molecular structure and potential therapeutic uses. As such, (11S,17S)-11,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol serves as an excellent case study for students and researchers alike in the ever-evolving field of chemistry.

Synonyms
DTXSID60946455
11-Methylestra-1(10),2,4-triene-3,17-diol