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1,2-dichloro-4-nitrobenzene

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Identification
Molecular formula
C6H3Cl2NO2
CAS number
99-54-7
IUPAC name
1,2-dichloro-4-nitro-benzene
State
State

1,2-Dichloro-4-nitrobenzene is generally found in a solid state at room temperature. It typically exists as crystalline solids with a distinct yellow coloration.

Melting point (Celsius)
53.00
Melting point (Kelvin)
326.15
Boiling point (Celsius)
256.00
Boiling point (Kelvin)
529.15
General information
Molecular weight
193.00g/mol
Molar mass
192.9990g/mol
Density
1.5160g/cm3
Appearence

1,2-Dichloro-4-nitrobenzene often appears as a pale yellow crystalline solid. The compound can form fine needles or crystals and is typically aromatic in nature due to the benzene ring present in its structure.

Comment on solubility

Solubility of 1,2-Dichloro-4-nitrobenzene

1,2-Dichloro-4-nitrobenzene (C6H4Cl2NO2) presents an interesting case in terms of solubility characteristics. Being an aromatic compound with both chlorine and nitro substituents, its solubility profile in various solvents differs markedly:

  • In organic solvents: This compound is generally soluble in organic solvents such as benzene, ethanol, and acetone due to its non-polar aromatic nature.
  • In water: 1,2-Dichloro-4-nitrobenzene exhibits low solubility in water. The polar nitro group does provide some degree of interaction with water, but the presence of the two chlorine atoms limits its overall solubility.
  • Environmental considerations: Its limited solubility in water raises important environmental and toxicological considerations, as it may persist in soil and organic phases of aquatic systems.

In summary, while 1,2-dichloro-4-nitrobenzene is soluble in many organic solvents, its poor solubility in water makes it a compound of particular interest for studies on environmental impact and remediation strategies.

Interesting facts

Interesting Facts about 1,2-Dichloro-4-nitro-benzene

1,2-Dichloro-4-nitro-benzene is a fascinating chemical compound that has garnered attention in both industrial applications and research contexts. It is a member of the nitro aromatic compounds, which are well-known for their diverse utilities in the chemical industry.

Key Characteristics and Applications:

  • Versatile Intermediate: This compound serves as an important intermediate in the synthesis of various pharmaceuticals and agrochemicals, showcasing its role in advancing medicinal chemistry.
  • Research Applications: It is often utilized in the study of environmental impact due to its potential as a pollutant, thus helping scientists understand the degradation processes of similar compounds.
  • Analytical Chemistry: 1,2-Dichloro-4-nitro-benzene is frequently used as a standard in analytical techniques, allowing chemists to calibrate instruments for precision in measurements.

Chemical Behavior:

This compound exhibits interesting chemical reactivity. For instance, the presence of both chloro and nitro groups:

  • Enhances electrophilic substitution reactions, allowing for further functionalization.
  • May lead to unique mechanisms of action in biological studies, particularly in the pharmacological examination of its derivatives.

Environmental and Safety Considerations:

Due to its chlorine content, 1,2-dichloro-4-nitro-benzene poses certain environmental safety challenges. Laboratory safety protocols must be strictly followed, as exposure can potentially lead to:

  • Health hazards, including skin and respiratory irritation.
  • Environmental concerns regarding its persistence and potential toxicity in soil and water bodies.

In summary, 1,2-Dichloro-4-nitro-benzene is not only a versatile intermediate in chemical synthesis but also a compound of significant interest in environmental studies and analytical chemistry. Its unique properties and interactions make it a noteworthy subject for research and industrial applications.

Synonyms
3,4-DICHLORONITROBENZENE
1,2-Dichloro-4-nitrobenzene
99-54-7
1-Nitro-3,4-dichlorobenzene
Benzene, 1,2-dichloro-4-nitro-
DCNB
3,4-Dichlornitrobenzen
CCRIS 3097
1,2-Dichloro-4-nitro-benzene
3,4-Dichloronitrobenzen
3,4-Dichlornitrobenzen [Czech]
HSDB 4252
3,4-Dichloronitrobenzen [Czech]
UNII-IJT74JI7FS
IJT74JI7FS
NSC 6295
AI3-03268 (USDA)
EINECS 202-764-2
BRN 1818163
DTXSID8024999
AI3-03268
NSC-6295
NSC-99806
3,4-dichloro-1-nitrobenzene
DTXCID504999
EC 202-764-2
3,4-DICHLORONITROBENZENE [HSDB]
WLN: WNR CG DG
Benzene,2-dichloro-4-nitro-
CAS-99-54-7
3,4-DICHLORONITROBENZEN (CZECH)
1,2-Dichloro-4-nitrobenzene; 1-Nitro-3,4-dichlorobenzene; 3,4-Dichloronitrobenzene; DCNB; NSC 6295; NSC 99806
3,4Dichlornitrobenzen
3,4Dichloronitrobenzen
1,2Dichloro4nitrobenzene
1Nitro3,4dichlorobenzene
3, 4-dichloronitrobenzene
3,4-dichloro-nitrobenzene
3,4-dichloro-nitro benzene
Benzene, 1,2dichloro4nitro
SCHEMBL85918
3,4-dichloro- 1-nitrobenzene
CHEMBL167468
NSC6295
AI303268 (USDA)
NSC99806
STR01633
Tox21_201613
Tox21_300293
MFCD00007207
STL256829
1,2-Dichloro-4-nitrobenzene, 99%
AKOS005157643
FD70434
3,4-Dichloronitrobenzene ; 3,4-DCNB
NCGC00091637-01
NCGC00091637-02
NCGC00091637-03
NCGC00091637-04
NCGC00254103-01
NCGC00259162-01
DB-003354
CS-0164308
D0388
NS00010037
EN300-54305
Methyl1-benzyl-5-oxo-3-pyrrolidinecarboxylate
A19495
E78961
Q2469366
1,2-dichloro-4-nitrobenzene? (Afatinib Impurity pound(c)
1,2-Dichloro-4-nitrobenzene, PESTANAL(R), analytical standard