1,2-diphenyl-2-piperazin-1-yl-ethanone

Identification

Molecular formula

C₂₀H₂₂N₂O

CAS number

78410-68-9

IUPAC name

1,2-diphenyl-2-piperazin-1-yl-ethanone

State

At room temperature, 1,2-diphenyl-2-piperazin-1-yl-ethanone is in a solid state. It exhibits good stability under standard atmospheric conditions and does not readily sublimate or decompose unless exposed to temperatures above its melting point.

Melting point (Celsius)

174.00

Melting point (Kelvin)

447.15

Boiling point (Celsius)

416.40

Boiling point (Kelvin)

689.55

General information

Molecular weight

308.40g/mol

Molar mass

308.3960g/mol

Density

1.1450g/cm³

Appearence

1,2-diphenyl-2-piperazin-1-yl-ethanone appears as a crystalline solid. It is white to off-white in color, depending on the degree of purity and the presence of any impurities. It is not hygroscopic and maintains its solid form under normal environmental conditions.

Comment on solubility

Solubility of 1,2-Diphenyl-2-piperazin-1-yl-ethanone

The solubility of 1,2-diphenyl-2-piperazin-1-yl-ethanone is a significant attribute that can influence its applications in various fields such as pharmaceuticals and chemical synthesis. Here are some key points regarding its solubility:

Organic Solvents: This compound is generally soluble in organic solvents, which often aids in its use in chemical reactions and formulations.
Water Solubility: As a rule of thumb, many piperazine derivatives tend to have limited solubility in water due to their hydrophobic aromatic rings, which could affect the bioavailability of the compound.
pH Influence: The solubility may be influenced by the pH of the solution, with certain conditions enhancing or reducing solubility based on possible ionization.
Temperature Dependence: Generally, an increase in temperature can improve the solubility of organic compounds, which may apply to 1,2-diphenyl-2-piperazin-1-yl-ethanone as well.

In conclusion, the solubility characteristics of 1,2-diphenyl-2-piperazin-1-yl-ethanone play a crucial role in its functionality and versatility. Understanding these solubility dynamics allows for optimizing its usage in practical applications.

Interesting facts

Interesting Facts About 1,2-Diphenyl-2-piperazin-1-yl-ethanone

1,2-Diphenyl-2-piperazin-1-yl-ethanone is a fascinating compound that belongs to the class of piperazine derivatives. Here are some intriguing aspects of this compound:

Structural Versatility: The structure features a piperazine ring, which is a common motif in various pharmaceuticals, known for enhancing binding interactions with biological targets.
Pharmacological Importance: Compounds with a piperazine framework are often studied for their potential therapeutic effects, including antidepressant and antipsychotic activity, making this compound of interest in medicinal chemistry.
Isomeric Nature: The presence of diphenyl groups allows for different isomers, thereby offering a unique opportunity to explore the effects of molecular configuration on bioactivity.
Synthetic Pathways: The synthesis of this compound often involves multi-step organic synthesis techniques, showcasing the complexity and creativity inherent in organic chemistry.
Role in Research: Due to its unique chemical features, it serves as a valuable intermediate or lead compound for further modification in drug development and research.

In summary, 1,2-diphenyl-2-piperazin-1-yl-ethanone is more than just a chemical name; it embodies a breadth of opportunities in therapeutic research, structural chemistry, and synthetic methodologies. Its varied applications and significance in the pharmaceutical industry underscore the importance of studying such compounds in-depth.

Synonyms

O1R2ZXF3HD

2-Phenyl-2-piperazinylacetophenone

UNII-O1R2ZXF3HD

1,2-Diphenyl-2-(1-piperazinyl)ethanone

Acetophenone, 2-phenyl-2-(1-piperazinyl)-

Ethanone, 1,2-diphenyl-2-(1-piperazinyl)-

94067-15-9

SCHEMBL10772016