Skip to main content

Colchicine

ADVERTISEMENT
Identification
Molecular formula
C22H25NO6
CAS number
64-86-8
IUPAC name
1,2,10-trimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium-11-ol
State
State

Colchicine is a solid at room temperature, generally available as a crystalline powder.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.15
Boiling point (Celsius)
355.00
Boiling point (Kelvin)
628.15
General information
Molecular weight
399.44g/mol
Molar mass
399.4380g/mol
Density
1.2000g/cm3
Appearence

Colchicine typically appears as a pale yellow powder or crystals.

Comment on solubility

Solubility of 1,2,10-trimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium-11-ol

The solubility of 1,2,10-trimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium-11-ol can be understood through various factors that affect its interactions in solution. Generally, its behavior in different solvents can be categorized as follows:

  • Polar Solvents: Due to the presence of multiple methoxy groups, which enhance polarity, this compound tends to show good solubility in polar solvents like water and methanol.
  • Non-Polar Solvents: The hydrophobic character from the complex polycyclic structure may limit solubility in non-polar solvents such as hexane or benzene.
  • Temperature Effects: Increasing temperature can often lead to enhanced dissolution rates for many compounds, including this quinolin-structured molecule.
  • pH Influence: The solubility can also be pH-dependent, especially if the compound possesses ionizable functional groups.

In conclusion, the solubility of this compound exhibits a nuanced behavior influenced by its chemical structure and intrinsic properties. Understanding these factors helps in predicting its behavior in various environments, which is crucial for applications in both research and industry.

Interesting facts

Interesting Facts About 1,2,10-trimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium-11-ol

This fascinating compound is a member of the quinolinium family, which possesses significant biological activity and intriguing structural features. Here are some key points that highlight its importance:

  • Bioactivity: Compounds like this one have been studied for their potential therapeutic effects, particularly in the realms of anti-cancer and anti-inflammatory properties. Research has shown that similar structures can interact with various cellular pathways, promoting or inhibiting physiological responses.
  • Chemical Complexity: The molecule features multiple functional groups, notably three methoxy groups and a unique dibenzo structure. This complexity can lead to interesting chemical behaviors and interactions, making it a subject of interest in synthetic organic chemistry.
  • Synthesis Challenges: The synthesis of such polycyclic compounds often involves intricate multi-step procedures, requiring careful planning and knowledge of reaction mechanisms. Chemists must navigate reaction conditions, selecting appropriate reagents to yield a high-purity product.
  • Potential Applications: While its precise applications are still being explored, the compound's unique structure may lend itself to advancements in materials science, specifically in creating new organic semiconductors or solar cells due to its electronic properties.
  • Research Opportunities: The depth of study surrounding quinolinium derivatives opens numerous avenues for researchers, fostering collaboration across disciplines like pharmacology, medicinal chemistry, and material science.

In summary, 1,2,10-trimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium-11-ol is not merely a molecule; it represents a confluence of chemistry and potential innovation. As scientists continue to unravel its mysteries, the compound may play a key role in future research and development.

Synonyms
Menisperine
Isocorydine methochloride
25342-82-9
1,2,10-trimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo(de,g)quinoline-6-ium-11-ol
(6aS)-1,2,10-trimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo(de,g)quinolin-6-ium-11-ol
RefChem:925482
Menispermine
1,2,10-trimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium-11-ol
CHEMBL175775
SCHEMBL29368629
ABA34282