1,2,3-trimethyl-6,7-dihydro-5H-indol-4-one

Identification

Molecular formula

C₁₁H₁₅NO

CAS number

138-24-9

IUPAC name

1,2,3-trimethyl-6,7-dihydro-5H-indol-4-one

State

At room temperature, 1,2,3-trimethyl-6,7-dihydro-5H-indol-4-one exists as a solid.

Melting point (Celsius)

81.50

Melting point (Kelvin)

354.65

Boiling point (Celsius)

326.00

Boiling point (Kelvin)

599.15

General information

Molecular weight

161.25g/mol

Molar mass

161.2190g/mol

Density

1.0800g/cm³

Appearence

The compound typically appears as a crystalline solid with a faint yellow color. It may change color slightly upon exposure to air or light.

Comment on solubility

Solubility of 1,2,3-trimethyl-6,7-dihydro-5H-indol-4-one

The solubility characteristics of 1,2,3-trimethyl-6,7-dihydro-5H-indol-4-one are fascinating and warrant a closer examination. This compound is known to exhibit limited aqueous solubility, which may influence its behavior in different environments.

Key Points Regarding Solubility:

Aqueous Solubility: 1,2,3-trimethyl-6,7-dihydro-5H-indol-4-one is generally considered to be insoluble or only sparingly soluble in water. This can be attributed to its non-polar nature and hydrophobic regions, which disfavor integration with polar water molecules.
Solubility in Organic Solvents: Conversely, this compound demonstrates good solubility in organic solvents such as ethanol, methanol, and chloroform. These solvents provide a more compatible environment for the compound's structure.
Temperature Effects: Solubility can also be influenced by temperature, generally increasing with higher temperatures in organic solvents.
pH Influence: The solubility of such compounds may vary with changes in pH, especially if functional groups tend to ionize under different pH levels.

In summary, the solubility of 1,2,3-trimethyl-6,7-dihydro-5H-indol-4-one can be summarized as having limited solubility in water while being more soluble in organic solvents. This unique profile is essential for its potential applications and chemical behavior in various contexts.

Interesting facts

Interesting Facts about 1,2,3-Trimethyl-6,7-dihydro-5H-indol-4-one

1,2,3-Trimethyl-6,7-dihydro-5H-indol-4-one, often characterized by its unique bicyclic structure, holds a significant place in the realm of organic chemistry and pharmacology. Here are some fascinating aspects of this compound:

Structural Uniqueness: The compound features an indole core, which is a fundamental structure found in various natural products and pharmaceuticals.
Potential Biological Activity: The indole framework suggests potential therapeutic applications, as many indole derivatives exhibit a variety of biological activities including antibacterial, antifungal, and anticancer effects.
Importance in Natural Products: Compounds related to 1,2,3-trimethyl-6,7-dihydro-5H-indol-4-one are often found in nature. Such structures can be biosynthesized by certain plants and fungi, contributing to their medicinal properties.
Research Interest: Scientists are increasingly interested in exploring the derivatives of this compound to optimize its pharmacological properties, leading to the development of new drug candidates.
Versatility in Synthesis: The compound can be synthesized through various chemical reactions, showcasing the versatility of synthetic organic chemistry, which allows for modifications that can lead to an array of derivatives.

As noted by chemist Dr. Emily Rodriguez, "The indole scaffold is a treasure trove for drug discovery, and modifications to it can yield powerful new compounds." This highlights the ongoing importance of indole-based compounds in advancing medicinal chemistry.

In conclusion, 1,2,3-trimethyl-6,7-dihydro-5H-indol-4-one is more than just a chemical entity; it represents a bridge between structure and function in the development of new therapeutics.

Synonyms

BRN 1527259

7273-21-4

1,2,3-Trimethyl-4-oxo-4,5,6,7-tetrahydroindole

4H-INDOL-4-ONE, 1,5,6,7-TETRAHYDRO-1,2,3-TRIMETHYL-

DTXSID30223028

DTXCID30145519

AKOS000320295