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Colchicine

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Identification
Molecular formula
C22H25NO6
CAS number
64-86-8
IUPAC name
1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
State
State

Colchicine is a solid at room temperature. It is relatively stable under normal conditions.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.15
Boiling point (Celsius)
235.00
Boiling point (Kelvin)
508.15
General information
Molecular weight
399.44g/mol
Molar mass
399.4380g/mol
Density
1.6600g/cm3
Appearence

Colchicine is an alkaloid and typically is encountered as a yellowish-white crystalline powder. It may also appear as needle-like crystals.

Comment on solubility

Solubility of 1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one

The solubility of the compound C22H25NO6 is a complex topic, influenced by its unique molecular structure and functional groups. Here are several key factors that play a role:

  • Polar vs Nonpolar Characteristics: The presence of methoxy groups introduces polar characteristics, which can enhance solubility in polar solvents such as water or alcohols.
  • Hydrophobic Regions: The hydrocarbon portion of the molecule may limit its solubility in highly polar solvents, suggesting that it may preferentially dissolve in organic solvents.
  • Functional Group Interactions: The amino group may create opportunities for hydrogen bonding, further influencing solubility behavior across different media.

In general, compounds with similar structures often show varied solubility patterns based on the balance between their hydrophilic and hydrophobic segments. As noted in solubility studies, "the more polar a compound, the more soluble it is generally in polar solvents." Therefore, while we can anticipate that this compound will demonstrate reasonable solubility in polar solvents, the actual solubility may vary, requiring experimental verification.

In summary, the solubility of C22H25NO6 can be expected to exhibit a nuanced behavior based on:

  1. Presence of polar functional groups
  2. Hydrophobic hydrocarbon structure
  3. Environmental pH and temperature

Understanding these factors can be essential for applications in pharmaceuticals and materials science.

Interesting facts

Exploring 1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one

1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one is a fascinating compound rich in structural complexity and potential applications. This organic compound is particularly noteworthy for several reasons:

  • Complex Structure: The compound's structure showcases a unique combination of methoxy groups and a methylamino group, contributing to its diverse chemical reactivity.
  • Potential Applications: Due to its structural properties, this compound may possess interesting pharmacological activities, making it a subject of investigation in medicinal chemistry.
  • Research Interest: Compounds with similar frameworks have been studied for their biological activities, including anti-cancer and anti-inflammatory properties, thus highlighting the potential of this compound in drug discovery.
  • Synthetic Pathways: The synthesis of this compound involves several intricate steps, which can provide valuable insights into organic synthesis techniques and methodologies.
  • Analytical Techniques: Understanding this compound requires the use of advanced analytical techniques such as NMR, MS, and IR spectroscopy, allowing chemists to decode its intricate structure.

In conclusion, 1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one stands out not just for its chemical structure but also for the potential it harbors in both research and application. As we continue to explore the capabilities of compounds like these, the door to innovation in medicinal chemistry remains wide open.

Synonyms
1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
102491-77-0
1,2,3,10-Tetramethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-one
1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
Colcemid;Colchamin;Desmecolcine;Kolchamin
NCGC00166035-01
MolMap_000011
SCHEMBL8160
DTXSID80859391
HMS3374M04
SYB60204
SYB66872
BBL027927
HSCI1_000384
STL377913
AKOS022144221
SB48584
VS-08623
DB-051473
NS00031719
BRD-A06124629-001-01-8
Q16959658
3,4,5,14-tetramethoxy-10-(methylamino)tricyclo[9.5.0.0(2),?]hexadeca-1(16),2,4,6,11,14-hexaen-13-one