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Tacrine hydrochloride

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Identification
Molecular formula
C13H15ClN2
CAS number
1684-40-8
IUPAC name
1,2,3,4-tetrahydroacridin-9-ylammonium;chloride
State
State

At room temperature, Tacrine hydrochloride is typically found in a solid state. It is available as a crystalline powder, allowing for ease of handling and measurement in experimental and clinical settings.

Melting point (Celsius)
247.00
Melting point (Kelvin)
520.15
Boiling point (Celsius)
337.00
Boiling point (Kelvin)
610.15
General information
Molecular weight
198.68g/mol
Molar mass
198.6780g/mol
Density
1.1100g/cm3
Appearence

Tacrine hydrochloride usually appears as a white or off-white crystalline powder, generally used in its hydrochloride salt form due to enhanced solubility. The material is often utilized in laboratories for research and pharmaceutical formulations, presenting a fine particulate texture.

Comment on solubility

Solubility of 1,2,3,4-Tetrahydroacridin-9-ylammonium Chloride

The solubility of 1,2,3,4-tetrahydroacridin-9-ylammonium chloride can be influenced by several factors including temperature, solvent type, and the presence of other ions in solution.

General Solubility Characteristics

  • Water Solubility: This compound exhibits a degree of solubility in water, primarily due to the ionic nature of the ammonium chloride group, which facilitates its interaction with water molecules.
  • Solvent Dependence: The solubility may vary in different solvents. Polar solvents tend to enhance solubility due to better interaction with the charged ammonium component.
  • Temperature Impact: Typically, increasing the temperature can increase the solubility of salts like ammonium chloride, allowing for more effective dissolution.

Based on solubility trends for ammonium salts, it can be stated that:

  1. In general, ammonium salts are quite soluble in water.
  2. The presence of the tetrahydroacridin group may provide unique interaction capabilities that could affect solubility.
  3. Careful experimentation is recommended to establish precise solubility under varying conditions.

In conclusion, while 1,2,3,4-tetrahydroacridin-9-ylammonium chloride is likely soluble in water, the exact quantification of its solubility may require further study to determine the optimal conditions for dissolution.

Interesting facts

Interesting Facts about 1,2,3,4-Tetrahydroacridin-9-ylammonium Chloride

1,2,3,4-Tetrahydroacridin-9-ylammonium chloride is a fascinating compound with diverse applications in many scientific fields. Here are some engaging facts about this intriguing substance:

  • Structure and Function: This compound features a unique bicyclic structure known as acridine, which contributes to its biochemical properties. The presence of the ammonium group plays a vital role in its ability to interact with biological systems.
  • Memory Enhancement: Research has indicated that tetrahydroacridine derivatives, particularly 1,2,3,4-tetrahydroacridin-9-ylammonium, may exhibit neuroprotective effects and could potentially enhance memory and cognitive functions. This has implications in the fields of neurobiology and pharmacology.
  • Role in Alzheimer's Research: The compound has been studied for its potential as a treatment for Alzheimer’s disease. It may offer a therapeutic pathway by inhibiting cholinesterase, an enzyme that breaks down acetylcholine, a neurotransmitter essential for memory and learning.
  • Polyvalent Interactions: The ammonium ion in its structure allows it to engage in various ionic and hydrogen bonding interactions, facilitating its use in drug design and materials chemistry.
  • Historical Significance: The exploration of acridine derivatives dates back to the early 20th century, making them a subject of ongoing scientific inquiry and highlighting their importance in medicinal chemistry.

Overall, 1,2,3,4-tetrahydroacridin-9-ylammonium chloride is a compound that bridges chemistry and biology, making it a significant focus for future research in treatments for cognitive diseases. As scientists continue to explore its properties, this compound is sure to remain at the forefront of neuropharmacological studies.