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Piperidine-5-carboxylic acid

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Identification
Molecular formula
C6H9NO2
CAS number
2906-12-9
IUPAC name
1,2,3,6-tetrahydropyridine-5-carboxylic acid
State
State

At room temperature, piperidine-5-carboxylic acid is a solid. Its crystalline structure makes it relatively stable under standard atmospheric conditions.

Melting point (Celsius)
198.00
Melting point (Kelvin)
471.00
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.00
General information
Molecular weight
129.15g/mol
Molar mass
129.1480g/mol
Density
1.2600g/cm3
Appearence

The compound typically appears as a white crystalline powder. Its clean, colorless crystals can reflect light, giving them a slight sheen. However, when finely powdered, it takes on a more matte appearance.

Comment on solubility

Solubility of 1,2,3,6-Tetrahydropyridine-5-carboxylic Acid

1,2,3,6-Tetrahydropyridine-5-carboxylic acid (C6H9NO2) exhibits unique solubility characteristics that are critical for its application in various fields of chemistry. Understanding its solubility can help predict its behavior in different environments.

Solubility Profile:

  • Water Solubility: This compound is known to be moderately soluble in water, which is primarily attributed to the presence of its carboxylic acid group.
  • Organic Solvents: 1,2,3,6-Tetrahydropyridine-5-carboxylic acid is often soluble in alcohols and other polar organic solvents, enhancing its versatility in synthetic applications.
  • pH Dependence: The solubility may vary significantly with pH; in more acidic conditions, the carboxylic acid group can become protonated, leading to decreased solubility.

Overall, the solubility of C6H9NO2 is influenced by various factors, including intermolecular interactions and the overall polarity of the solvent. It is important to consider these aspects when utilizing this compound in laboratory or industrial applications.

Interesting facts

1,2,3,6-Tetrahydropyridine-5-carboxylic Acid: An Insightful Exploration

1,2,3,6-Tetrahydropyridine-5-carboxylic acid is a fascinating compound that has garnered attention in both synthetic and medicinal chemistry. Below are some compelling facts that highlight its significance:

  • Chemical Versatility: This compound serves as a building block for various chemical syntheses, making it valuable in the pharmaceutical industry.
  • Biological Relevance: It has been studied for its potential therapeutic applications, particularly as a precursor in the synthesis of biologically active molecules.
  • Molecular Structure: The unique structure, featuring a fused ring system, contributes to its reactivity and interaction with biological systems.
  • Research Interest: Scientists are exploring its role in neurochemistry, particularly due to its resemblance to certain neurotransmitters.
  • Hydrogen Bonding: The presence of both carboxylic acid and nitrogen in its structure allows for multiple hydrogen bonding interactions, enhancing solubility in polar solvents.

In summary, 1,2,3,6-tetrahydropyridine-5-carboxylic acid is not only a key player in chemical synthesis but also an important subject in medicinal research. As one researcher noted, "the exploration of such compounds can lead to breakthroughs in drug design and discovery." Its intriguing characteristics and applications truly make it a compound worth studying.

Synonyms
Guvacine
498-96-4
1,2,5,6-tetrahydropyridine-3-carboxylic acid
1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid
1,2,5,6-Tetrahydronicotinic acid
1,2,5,6-Tetrahydro-pyridine-3-carboxylic acid
1,2,3,6-tetrahydropyridine-5-carboxylic acid
CHEBI:5576
GUVACINE [MI]
41538P325K
DTXSID50871702
3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-
MLS000859975
SMR000326834
UNII-41538P325K
MFCD01365700
Spectrum_001426
Tocris-0234
SpecPlus_000808
Lopac-G-007
Spectrum2_001474
Spectrum3_001511
Spectrum4_001753
Spectrum5_000606
Biomol-NT_000253
C10149
Lopac0_000571
BSPBio_003181
KBioGR_002226
KBioSS_001906
CHEMBL76768
DivK1c_006904
SCHEMBL336053
SPBio_001427
BPBio1_000838
GTPL4691
BDBM90787
KBio1_001848
KBio2_001906
KBio2_004474
KBio2_007042
KBio3_002681
DTXCID80819339
cid_11957555
QTDZOWFRBNTPQR-UHFFFAOYSA-N
HY-N2482
ZINC03872753
AKOS006282520
CCG-204660
DB08848
FS-8105
SB37356
SDCCGMLS-0066665.P001
SDCCGSBI-0050553.P003
NCGC00015457-01
NCGC00015457-02
NCGC00015457-03
NCGC00015457-04
NCGC00015457-05
NCGC00015457-08
NCGC00024508-01
NCGC00024508-02
NCGC00024508-03
DA-73950
1ST169082
CS-0022753
NS00069502
EN300-261948
F13202
1,2,3,6-tetrahydropyridin-1-ium-5-carboxylate
BRD-K01980392-003-11-6
Q15322708