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1,3-Benzoxazole-2-thiol

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Identification
Molecular formula
C7H5NOS
CAS number
147-94-4
IUPAC name
1,3-benzoxazole-2-thiol
State
State

At room temperature, 1,3-Benzoxazole-2-thiol is in a solid state. It is stable under normal conditions but should be stored in a cool, dry place to prevent any possible degradation.

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
352.00
Boiling point (Kelvin)
625.15
General information
Molecular weight
151.18g/mol
Molar mass
151.1810g/mol
Density
1.3210g/cm3
Appearence

1,3-Benzoxazole-2-thiol typically appears as a yellow crystalline solid. The crystals are often prismatic in shape, which contributes to its distinct appearance. It is generally considered a stable compound under standard conditions, yet it may have a distinctive sulfur-like odor due to the presence of the thiol group.

Comment on solubility

Solubility of 1,3-benzoxazole-2-thiol

1,3-benzoxazole-2-thiol (C7H5NOS) displays interesting solubility characteristics that can significantly impact its applications in various fields. Understanding its solubility is crucial for both theoretical and practical considerations.

In terms of solubility, it is important to note that:

  • Polarity: The presence of a thiol (-SH) functional group tends to increase the compound's polarity, enhancing its solubility in polar solvents.
  • Solvents: 1,3-benzoxazole-2-thiol is generally soluble in water and a variety of organic solvents, including:
    • Alcohols (e.g., ethanol, methanol)
    • Dimethyl sulfoxide (DMSO)
    • Aqueous solutions, particularly at elevated temperatures
  • Temperature: Increased temperature can lead to enhanced solubility, making it more effective in certain reactions.

It is often observed that, as the temperature rises, the solubility of 1,3-benzoxazole-2-thiol tends to increase, making it a versatile compound in organic synthesis and analytical chemistry.

Overall, the solubility of 1,3-benzoxazole-2-thiol is impacted by various factors including its structural characteristics and the nature of the solvent. These considerations are essential in ensuring effective utilization in research and applications.

Interesting facts

Interesting Facts about 1,3-benzoxazole-2-thiol

1,3-benzoxazole-2-thiol is a fascinating heterocyclic compound that plays a significant role in various fields of chemistry and biology. Here are some notable aspects of this compound:

  • Structural Diversity: The integration of a thiol group into the benzoxazole framework adds substantial reactivity, making it a valuable building block in organic synthesis.
  • Biological Significance: Compounds like 1,3-benzoxazole-2-thiol exhibit interesting biological activities, such as antimicrobial and anti-inflammatory properties, which make them candidates for medicinal chemistry.
  • Fluorescence: The compound can display fluorescence under specific conditions, allowing for its use in various imaging applications in biological and material sciences.
  • Analytical Chemistry: Due to its reactive thiol group, it can be employed in analytical methods for the detection of metal ions, making it a useful tool in environmental chemistry.
  • Synthetic Utility: It serves as a precursor in the synthesis of pharmaceuticals and agrochemicals, demonstrating its versatility in synthetic chemistry.

In summary, 1,3-benzoxazole-2-thiol is not just an ordinary compound but a potent entity with a myriad of applications across chemical research. As a chemistry student or professional, understanding its properties and reactivity can lead to innovative approaches in drug development and other scientific endeavors.