Interesting facts
Interesting Facts About 1,3-bis(2-chloroethyl)-1-nitroso-urea
1,3-bis(2-chloroethyl)-1-nitroso-urea, commonly referred to as *BCNU*, is a compound that plays a crucial role in the field of medical chemistry, particularly in cancer treatment. Here are several engaging insights about this fascinating compound:
- Chemotherapy Agent: BCNU is primarily known for its applications in chemotherapy, particularly for brain tumors and certain types of lymphomas. It works by disrupting the DNA of cancer cells, preventing them from dividing and growing.
- Mechanism of Action: This compound functions as an alkylating agent, which means it adds alkyl groups to DNA. This process leads to cross-linking of DNA strands, ultimately triggering cell death.
- Combination Therapy: BCNU is often used in combination with other chemotherapeutic agents to enhance its efficacy. Its synergistic effects can lead to improved treatment outcomes for patients.
- Side Effects: Though effective, BCNU can have significant side effects, including suppression of bone marrow function, which can lead to anemia and increased risk of infections. Understanding these effects is vital for managing patient care.
- Research and Development: Ongoing research into the modifications of BCNU and its derivatives is being conducted to make it more effective and reduce its side effects. Scientists are relentless in this pursuit to optimize its therapeutic potential.
As we continue to explore the chemical landscape, compounds like *1,3-bis(2-chloroethyl)-1-nitroso-urea* remind us of the remarkable intersection of chemistry and medicine. Indeed, the study of such compounds is instrumental in paving the way for innovative treatments that can significantly impact human health.
Synonyms
carmustine
154-93-8
1,3-Bis(2-chloroethyl)-1-nitrosourea
BCNU
Carmustin
Carmubris
Gliadel
Nitrumon
BiCNU
Becenun
1,3-Bis(2-chloroethyl)nitrosourea
Bischloroethyl nitrosourea
Bi CNU
Carmustina
Carmustinum
Bischlorethylnitrosurea
Bischlorethylnitrosourea
Becenum
N,N'-BIS(2-CHLOROETHYL)-N-NITROSOUREA
Urea, N,N'-bis(2-chloroethyl)-N-nitroso-
Bis(2-chloroethyl)nitrosourea
NSC-409962
Bischloroethylnitrosourea
FDA 0345
SRI 1720
DTI 015
NCI-C04773
SK 27702
BiCNU (TN)
Carmustinum [INN-Latin]
Bis(2-chloroethyl)1-nitrosourea
Carmustina [INN-Spanish]
Bis-N,N'-(chloroethyl)nitrosourea
Carmustine (98%)
CCRIS 810
Camustine
Carustine
NSC 409962
1,3-Bis(beta-chloroethyl)-1-nitrosourea
Bis(chloroethyl)nitrosourea
EINECS 205-838-2
NSC409962
UNII-U68WG3173Y
BRN 2049744
CHEBI:3423
DTXSID8022743
AI3-52216
HSDB 7761
Urea, 1,3-bis(2-chloroethyl)-1-nitroso-
U68WG3173Y
bis-chloroethylnitrosourea
FDA-0345
SRI-1720
MFCD00057706
CHEMBL513
SK-27702
DTXCID002743
DTI-015
Carmustine [USAN:USP:INN:BAN]
1,3-bis(2-chloroethyl)-3-nitrosourea
NCGC00015204-05
FIVB
1,3-Bis(.beta.-chloroethyl)-1-nitrosourea
Gliadel Wafer
Carmustinum (INN-Latin)
Carmustina (INN-Spanish)
CARMUSTINE (MART.)
CARMUSTINE [MART.]
CARMUSTINE (USP-RS)
CARMUSTINE [USP-RS]
CARMUSTINE (EP IMPURITY)
CARMUSTINE [EP IMPURITY]
CARMUSTINE (EP MONOGRAPH)
CARMUSTINE [EP MONOGRAPH]
CARMUSTINE (USP MONOGRAPH)
CARMUSTINE [USP MONOGRAPH]
Carmustine (USAN:USP:INN:BAN)
BISCHLOROETHYL NITROSOUREA (IARC)
BISCHLOROETHYL NITROSOUREA [IARC]
CAS-154-93-8
BCNU [Chloroethyl nitrosoureas]
Carmustine; 1,3-bis(2-chloroethyl)-1-nitrosourea
SR-01000075736
Nitrourean
Carmustine?
BiCNU; Nitrumon
Prestwick_997
Gliadel (TN)
Bischloroethyl nitrosourea [Chloroethyl nitrosoureas]
Carmustine (Standard)
Gliadel (MGI Pharm)
1,3-bis(2-chloroethyl)-1-nitroso-urea
Spectrum_000265
Carmustine, >=98%
CARMUSTINE [MI]
CARMUSTINE [INN]
CARMUSTINE [JAN]
Spectrum4_000888
Spectrum5_000920
CAMUSTINE [VANDF]
CARMUSTINE [HSDB]
CARMUSTINE [USAN]
Lopac-C-0400
WLN: ONN2GVM2G
C 0400
bis(chloroethyl) nitrosourea
SCHEMBL4503
CARMUSTINE [WHO-DD]
Lopac0_000188
Carmustine (JAN/USP/INN)
KBioGR_001296
KBioSS_000745
MLS001333962
DivK1c_000835
bis-(2-Chloroethyl)nitrosourea
Carmustine - Bio-X trade mark
GTPL6800
CARMUSTINE [ORANGE BOOK]
HMS502J17
KBio1_000835
KBio2_000745
KBio2_003313
KBio2_005881
L01AD01
NINDS_000835
HMS2092J22
HMS2230I05
HMS3260F17
HMS3369D17
Pharmakon1600-01503110
BCP27690
Tox21_110097
Tox21_500188
BDBM50015950
CCG-39925
HY-13585R
NSC758392
STK624770
n,n-bis(2-chloroethyl)-n-nitrosourea
1,3-bis(2-chlorethyl)-1-nitrosourea
AKOS005558013
Tox21_110097_1
BCP9000490
DB00262
FC19817
LP00188
NSC-758392
SDCCGSBI-0050176.P004
IDI1_000835
Urea,3-bis(2-chloroethyl)-1-nitroso-
NCGC00015204-01
NCGC00015204-02
NCGC00015204-03
NCGC00015204-04
NCGC00015204-06
NCGC00015204-07
NCGC00015204-08
NCGC00015204-09
NCGC00015204-18
NCGC00093665-01
NCGC00093665-02
NCGC00093665-03
NCGC00093665-04
NCGC00260873-01
Urea,N'-bis(2-chloroethyl)-N-nitroso-
AC-24196
AS-12106
BC164289
HY-13585
N,N''-Bis(2-chloroethyl)-N-nitrosourea
NCI60_003931
SMR000058426
SBI-0050176.P003
WR-139021
C2634
EU-0100188
NS00005564
S3669
A12097
BCNU; 1,3-Bis(2-chloroethyl)-1-nitrosourea
C06873
D00254
EN300-123541
AB00052431-07
AB00052431_08
Q415869
SR-01000075736-1
SR-01000075736-3
N,N'-bis(2-chloroethyl)-N-nitrosourea;NSC-409962
Z1269141329
Carmustine, United States Pharmacopeia (USP) Reference Standard
N,N'-Bis(2-chloroethyl)-N-nitrosourea, NSC-409962, Becenun
1-(2-Chloroethyl)-1-([(2-chloroethyl)amino]carbonyl)-2-oxohydrazine #
205-838-2
Solubility of 1,3-bis(2-chloroethyl)-1-nitroso-urea (C5H9Cl2N3O2)
The solubility characteristics of 1,3-bis(2-chloroethyl)-1-nitroso-urea, a compound known for its biological activity, can vary significantly depending on the solvent used. Generally, the following points can be noted regarding its solubility:
In practical applications, the solubility of this compound may influence its *bioavailability* and therapeutic efficacy. In order to achieve optimal results in biological assays or therapeutic uses, understanding its solubility profile is crucial. As a general rule, it is advisable to test solubility in various solvent systems to identify the most appropriate conditions for its use.