Skip to main content

Cimetidine

ADVERTISEMENT
Identification
Molecular formula
C13H16N6O
CAS number
51481-61-9
IUPAC name
1,3-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea;dihydrochloride
State
State

Solid at room temperature.

Melting point (Celsius)
142.00
Melting point (Kelvin)
415.00
Boiling point (Celsius)
368.00
Boiling point (Kelvin)
641.00
General information
Molecular weight
252.34g/mol
Molar mass
252.3440g/mol
Density
1.3900g/cm3
Appearence

White to off-white crystalline powder.

Comment on solubility

Solubility of 1,3-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea; dihydrochloride

The solubility of 1,3-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea; dihydrochloride can be quite intriguing due to the nature of its chemical structure.

This compound exhibits particular characteristics when it comes to solubility:

  • Solubility in Water: It is generally soluble in water due to the presence of the dihydrochloride salt, which increases the ionic nature of the compound.
  • Organic Solvents: The solubility may vary in polar and non-polar organic solvents, with a tendency for better solubility in polar solvents.
  • Temperature Influence: An increase in temperature can enhance solubility, a common phenomenon in many chemical compounds.
  • pH Dependence: The solubility might be pH-dependent, particularly if there are any protonation sites in the molecule.

As observed, the interplay of structural and environmental factors plays a crucial role in determining solubility; "understanding these parameters is vital for effective application in various chemical processes." Therefore, studying solubility is essential for practical utilization, especially in pharmaceutical contexts where solubility affects bioavailability.

Interesting facts

Interesting Facts about 1,3-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea; dihydrochloride

This compound, known as 1,3-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea; dihydrochloride, is a fascinating example of a molecule that merges both medicinal and synthetic chemistry. Here are some engaging insights about this compound:

  • Biological Relevance: This compound has shown potential in biomedical research, particularly in the field of cancer therapeutics. Its structure suggests that it could interact with specific cellular targets, making it a candidate for further investigations in drug development.
  • Urea Derivatives: The urea functional group in this compound plays a crucial role in medicinal chemistry. Urea and its derivatives are known for their ability to mimic peptide bonds, leading to improved selectivity and efficacy in therapeutic applications.
  • Synthetic Versatility: The synthetic route to this compound involves a combination of organic reactions that highlight the versatility of urea chemistry. Chemists can employ various strategies to modify the phenyl and imidazole components, thus creating a diversity of derivatives that can be tailored for specific functions.
  • Imidazole Influence: The presence of the 4,5-dihydro-1H-imidazol-2-yl group enhances the compound's potential for biological interaction. Imidazole is a common motif in pharmaceuticals, often contributing to enzyme inhibition and receptor binding activities.
  • Overcoming Resistance: Given its unique structure, this compound may provide insights into overcoming drug resistance in tumors. Research into similar diamine derivatives has yielded important lessons in modifying drugs that can effectively bypass established resistance mechanisms.

In summary, 1,3-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea; dihydrochloride is not just a multi-functional compound; it exemplifies the intersection of theoretical chemistry and practical application, showcasing the endless possibilities inherent in organic synthesis and medicinal chemistry.

Synonyms
Imidocarb hydrochloride
Imidocarb dihydrochloride
5318-76-3
Imidocarb HCl
Imizocarb
Diamidine (babesicide)
Imidocarb hydrochloride [USAN]
UNII-KCC1V76AH8
EINECS 226-179-7
KCC1V76AH8
NSC 51189
3,3'-Di-2-imidazolin-2-ylcarbanilide dihydrochloride
NSC-51189
Urea, N,N'-bis(3-(4,5-dihydro-1H-imidazol-2-yl)phenyl)-, dihydrochloride
Imidocarb hydrochloride (USAN)
DTXSID30201240
IMIDOCARB DIHYDROCHLORIDE [MI]
IMIDOCARB HYDROCHLORIDE [MART.]
CARBANILIDE, 3,3'-DI-2-IMIDAZOLIN-2-YL-, DIHYDROCHLORIDE
N,N'-BIS(3-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)PHENYL)UREA DIHYDROCHLORIDE
IMIDOCARB HYDROCHLORIDE (MART.)
SJ000113875
Hydrochloride, Imidocarb
Dihydrochloride, Imidocarb
DTXCID30123731
226-179-7
4A65
1,3-Bis(3-(4,5-dihydro-1H-imidazol-2-yl)phenyl)urea dihydrochloride
1,3-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea dihydrochloride
Imidocarb dihydrochloride monohydrate
CHEMBL3989411
MLRXMTYSQKIKAK-UHFFFAOYSA-N
1,3-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea,dihydrochloride
1,3-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea;dihydrochloride
AKOS024278485
NS00081449
D04512
Q27282180
1,3-Bis(3-(4,5-dihydro-1H-imidazol-2-yl)phenyl)ureadihydrochloride