Skip to main content

1,3-Bis(4-nitrophenyl)urea

ADVERTISEMENT
Identification
Molecular formula
C7H7N3O3
CAS number
13114-11-3
IUPAC name
1,3-bis(4-nitrophenyl)urea;4,6-dimethyl-1H-pyrimidin-2-one
State
State

At room temperature, 1,3-Bis(4-nitrophenyl)urea is a solid. It remains stable when exposed to air under normal conditions, but precautions should be taken to avoid exposure to strong acids or bases, which may cause decomposition.

Melting point (Celsius)
272.00
Melting point (Kelvin)
545.00
Boiling point (Celsius)
435.00
Boiling point (Kelvin)
708.00
General information
Molecular weight
320.29g/mol
Molar mass
320.2940g/mol
Density
1.4820g/cm3
Appearence

1,3-Bis(4-nitrophenyl)urea typically appears as a crystalline solid. The crystals may vary in color from pale yellow to beige, signifying its purity and the presence of any impurities. It is usually odorless or may have a slight aromatic odor due to the nitrophenyl groups present in its structure. The compound is often used in scientific research settings, particularly in organic synthesis and studies related to urea derivatives.

Comment on solubility

Solubility of 1,3-bis(4-nitrophenyl)urea; 4,6-dimethyl-1H-pyrimidin-2-one

The solubility characteristics of the compound 1,3-bis(4-nitrophenyl)urea; 4,6-dimethyl-1H-pyrimidin-2-one can be discussed in several key aspects:

  • Polarity: This compound has both polar and non-polar regions due to the presence of nitrophenyl groups and the pyrimidin-2-one component, which affects its solubility in various solvents.
  • Solvent compatibility: Typically, compounds with similar polarities tend to dissolve well together. This means:
    • It is likely to be soluble in polar solvents like ethanol or methanol.
    • It may exhibit limited solubility in non-polar solvents such as hexane or benzene.
  • Temperature dependence: Solubility can vary significantly with temperature. Generally:
    • Higher temperatures may enhance the solubility of solid compounds in liquid solvents.
    • Be aware that temperature increases can also lead to changes in chemical structure, potentially affecting solubility.

In addition, it is important to note that ionic interactions and hydrogen bonding in the solution can further influence solubility. For example, the presence of functional groups capable of forming hydrogen bonds may enhance solubility in water or other hydrogen-bonding solvents.

In conclusion, while experimental data would ultimately define the exact solubility profile of 1,3-bis(4-nitrophenyl)urea; 4,6-dimethyl-1H-pyrimidin-2-one, considerations of polarity, solvent type, temperature, and intermolecular interactions are critical factors to keep in mind.

Interesting facts

1,3-bis(4-nitrophenyl)urea

1,3-bis(4-nitrophenyl)urea is a fascinating compound with multiple applications across various fields of science. Here are some interesting facts:

  • Discovery: This compound has been studied for its potential roles in pharmaceuticals due to its unique structural features.
  • Biological Activity: It has been observed to exhibit significant biological activities, making it a subject of interest in medicinal chemistry.
  • Photophysical Properties: The nitro groups attached to the phenyl rings confer interesting photophysical properties that are valuable in research.
  • Environmental Chemistry: Due to its nitro groups, it is also explored in the context of environmental stability and degradation.

Researchers often discuss the compound in relation to its potential applications in drug development, showcasing the importance of structural modifications in enhancing bioactivity.


4,6-dimethyl-1H-pyrimidin-2-one

4,6-dimethyl-1H-pyrimidin-2-one is another intriguing compound with notable importance, particularly in the realm of organic chemistry. Here are some compelling insights:

  • Synthetic Versatility: This compound serves as an important building block in the synthesis of numerous heterocyclic compounds.
  • Pharmaceutical Relevance: Its derivatives are often used in the development of new pharmaceuticals, particularly those targeting neurological conditions.
  • Catalytic Applications: 4,6-dimethyl-1H-pyrimidin-2-one has explored catalytic properties in various reactions, making it significant in organic synthesis.
  • Research Studies: Scientific literature frequently examines its role in inhibiting enzymes, reflecting its potential as a lead compound.

The breadth of research surrounding 4,6-dimethyl-1H-pyrimidin-2-one illustrates its significance, as its structural diversity allows for modifications that can lead to novel therapeutic agents.

Synonyms
Nicarbazin
330-95-0
Nicarbazine
Nirazin
Nicoxin
Nicrazin
Nicrazine
Nicarb
Nicarbasin
MK 75
AI3-60130
HSDB 7466
NSC 7171
EINECS 206-359-1
UNII-11P9NUA12U
11P9NUA12U
NSC-7171
4,4'-Dinitrocarbanilide, 4,6-dimethyl-2-pyrimidinol
DTXSID6034762
CHEBI:81725
1,3-Bis(4-nitrophenyl)urea 4,6-dimethylpyrimidin-2-ol (1:1)
1,3-bis(4-nitrophenyl)urea;4,6-dimethyl-1H-pyrimidin-2-one
n,n'-bis(4-nitrophenyl)urea compound with 4,6-dimethyl-2-pyrimidinone
NICARBAZIN (MART.)
NICARBAZIN [MART.]
Urea, N,N-bis(4-nitrophenyl)-, compound with 4,6-dimethyl-2(1H)-pyrimidinone (1:1)
Nicarbazin [BAN]
MK 75 (VAN)
Nicarbazin; 1,3-Bis(4-nitrophenyl)urea 4,6-dimethylpyrimidin-2-ol; Nicarbazine
Nicarmix 25
MFCD00867204
Nicarb 25%
Nicarbazin (Standard)
NICARBAZIN [MI]
1,3-bis(4-nitrophenyl)urea,4,6-dimethyl-1H-pyrimidin-2-one
NICARBAZIN [HSDB]
Carbigran 25, Nicarbazin
CHEMBL95855
SCHEMBL578675
NICARBAZIN [GREEN BOOK]
1,3-Bis(4-nitrophenyl)urea-4,6-dimethylpyrimidin-2-ol
DTXCID4014762
4, 4,6-dimethyl-2-pyrimidinol
NSC7171
UKHWDRMMMYWSFL-UHFFFAOYSA-N
Tox21_304000
MFCD09033149
s4866
AKOS015900412
AKOS025310650
USEPA/OPP Pesticide Code: 85712
CCG-268958
HY-107814R
NCGC00357219-01
AS-13365
CAS-330-95-0
FN158224
SY038632
HY-107814
CS-0030690
NS00079489
C18389
D95916
Nicarbazin, VETRANAL(TM), analytical standard
Q2020694
1,3-bis(4-nitrophenyl)urea; 4,6-dimethylpyrimidin-2-ol
1,3-Bis-(4-nitro-phenyl)-urea and 4,6-Dimethyl-pyrimidin-2-ol
1,3-Bis(4-nitrophenyl)urea compd. with 4,6-dimethylpyrimidin-2(1H)-one(1:1)
N,N'-BIS(4-NITROPHENYL) UREA compound with 4,6-DIMETHYL -2-PYRIMIDINOL
206-359-1
N,N inverted exclamation marka-Bis(4-nitrophenyl)urea compd. with 4,6-dimethyl-2-pyrimidinol (1:1)