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Methohexital

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Identification
Molecular formula
C14H18N2O4
CAS number
151-83-7
IUPAC name
1,3-bis(ethoxymethyl)-5-ethyl-5-phenyl-hexahydropyrimidine-2,4,6-trione
State
State

Methohexital is a solid at room temperature. It is usually handled as a crystalline powder in pharmaceutical settings and is often reconstituted as a solution for medical use.

Melting point (Celsius)
214.00
Melting point (Kelvin)
487.15
Boiling point (Celsius)
370.00
Boiling point (Kelvin)
643.15
General information
Molecular weight
282.32g/mol
Molar mass
282.3220g/mol
Density
1.0946g/cm3
Appearence

Methohexital appears as a white crystalline powder. It is often odorless with a slightly bitter taste. The compound can exist in polymorphic forms, contributing to variations in its physical appearance. It is moderately soluble in water, and more soluble in alcohol and other organic solvents.

Comment on solubility

Solubility of 1,3-bis(ethoxymethyl)-5-ethyl-5-phenyl-hexahydropyrimidine-2,4,6-trione

The solubility of the compound 1,3-bis(ethoxymethyl)-5-ethyl-5-phenyl-hexahydropyrimidine-2,4,6-trione is influenced by several factors, which are crucial for its applications in various fields. While detailed solubility data may not be readily available, we can explore several aspects that typically affect the solubility of such complex organic compounds:

  • Polarity: The presence of ethoxymethyl and phenyl groups suggests varying polar character, impacting its solubility in different solvents.
  • Hydrogen Bonding: Given the trione functional groups, the compound may engage in hydrogen bonding, which can enhance solubility in polar solvents like water and alcohols.
  • Hydrophobic Effects: The ethyl and phenyl groups can confer hydrophobic characteristics, making the compound less soluble in polar solvents but more soluble in organic solvents.
  • Temperature: Increased temperature often improves solubility; thus, the compound may dissolve better when heated.

In conclusion, the solubility of 1,3-bis(ethoxymethyl)-5-ethyl-5-phenyl-hexahydropyrimidine-2,4,6-trione is likely to be a complex interplay of its structural attributes and external conditions. As observed in practice, understanding the solubility profile is essential for its effective utilization in chemical processes and formulations.

Interesting facts

Exploring 1,3-bis(ethoxymethyl)-5-ethyl-5-phenyl-hexahydropyrimidine-2,4,6-trione

The compound 1,3-bis(ethoxymethyl)-5-ethyl-5-phenyl-hexahydropyrimidine-2,4,6-trione is a fascinating molecule that falls within a class of compounds known as pyrimidines. These nitrogen-containing heterocycles are integral to various biological processes and synthetic applications. Here are some engaging insights regarding this unique compound:

  • Diverse Applications: Compounds like this pyrimidine derivative can serve as intermediates in pharmaceutical research, often exhibiting various biological activities that can be leveraged in drug discovery.
  • Structural Versatility: The presence of ethoxymethyl groups contributes to the compound's structural diversity, potentially influencing solubility and reactivity in different solvents.
  • Synthetic Pathways: The synthesis of hexahydropyrimidines often involves multi-step organic reactions, making it a subject of interest for chemists who enjoy exploring intricate synthesis techniques.
  • Biological Significance: Pyrimidine derivatives frequently play critical roles in cellular functions. Many nucleotides contain pyrimidines (such as cytosine and thymine), which are vital for DNA and RNA structures.
  • Potential for Research: Investigations into similar compounds reveal that modifications can lead to enhanced biological activity, highlighting the importance of structural modification in medicinal chemistry.

In summary, 1,3-bis(ethoxymethyl)-5-ethyl-5-phenyl-hexahydropyrimidine-2,4,6-trione is not just a simple organic molecule; its intricate structure and potential applications make it a captivating subject for ongoing scientific research and exploration. As we delve deeper into the realm of related compounds, we continue to uncover the vast possibilities that lie within the world of pyrimidines.

Synonyms
BARBITURIC ACID, 1,3-BIS(ETHOXYMETHYL)-5-ETHYL-5-PHENYL-
27512-03-4
DTXSID30181937
RefChem:1077470
DTXCID70104428
BRN 0628778
1,3-Bis(ethoxymethyl)-5-ethyl-5-phenylbarbituric acid