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Pipemidic acid

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Identification
Molecular formula
C14H17N3O3
CAS number
51940-44-4
IUPAC name
1,3-diazaspiro[4.5]decane-2,4-dione
State
State

At room temperature, pipemidic acid is a solid. It is stable under normal storage conditions typically expected for pharmaceutical compounds.

Melting point (Celsius)
214.00
Melting point (Kelvin)
487.15
Boiling point (Celsius)
355.00
Boiling point (Kelvin)
628.15
General information
Molecular weight
302.31g/mol
Molar mass
302.3070g/mol
Density
1.3570g/cm3
Appearence

Pipemidic acid appears as a white to slightly yellow crystalline powder. It is known for its typical appearance associated with many solid pharmaceutical compounds and has a slight odor.

Comment on solubility

Solubility of 1,3-Diazaspiro[4.5]decane-2,4-dione

Understanding the solubility of 1,3-diazaspiro[4.5]decane-2,4-dione is crucial for its applications in various chemical processes. This compound exhibits unique solubility properties that can be influenced by several factors:

  • Polarity: As a result of its spirocyclic structure and functional groups, this compound tends to have moderate polarity, which can affect how well it dissolves in different solvents.
  • Solvent Compatibility: It is generally more soluble in polar solvents such as water and alcohols, but less effective in non-polar solvents.
  • Temperature Effects: Solubility may increase with temperature, following the typical trend observed in many organic compounds, allowing for better dissolution in heated solutions.
  • pH Dependency: The protonation state of the 1,3-diazaspiro[4.5]decane-2,4-dione can change with pH, possibly enhancing its solubility in acidic or basic solutions.

In conclusion, while the specific solubility limits of 1,3-diazaspiro[4.5]decane-2,4-dione may not be extensively documented, its solubility is influenced by a blend of polarity, temperature, solvent choice, and pH. Investigating these interactions can lead to a better grasp of how this compound behaves in various solvent environments.

Interesting facts

Interesting Facts about 1,3-Diazaspiro[4.5]decane-2,4-dione

1,3-Diazaspiro[4.5]decane-2,4-dione is a fascinating compound that belongs to the family of spirocyclic compounds, which are known for their unique structure featuring two or more rings that share a single bond. Here are some captivating aspects of this compound:

  • Unique Structure: The spirocyclic framework of 1,3-diazaspiro[4.5]decane-2,4-dione contributes to its intriguing three-dimensional geometry, making it a subject of interest in stereochemistry.
  • Biological Relevance: Compounds with diaza groups, like this one, often exhibit significant biological activities, such as antimicrobial and anticancer properties. Research is ongoing into their potential medicinal applications.
  • Versatile Synthesis: The synthetic pathways leading to compounds like 1,3-diazaspiro[4.5]decane-2,4-dione often involve innovative organic reactions that challenge chemists to think creatively about bond formation and modification.
  • Pharmacophore Development: As a part of drug design, the molecule's framework can serve as a potential pharmacophore, suggesting it could interact with various biological targets, thus leading to discoveries in medicinal chemistry.

The exploration of 1,3-diazaspiro[4.5]decane-2,4-dione exemplifies how specific structural features can impact a compound's properties and functionalities. As scientists delve deeper into its characteristics, it may uncover promising developments in various fields, particularly in pharmacology and materials science.

In the words of a prominent chemist: "The beauty of organic chemistry lies not just in the compounds formed, but in the stories they tell through their structures."

Synonyms
1,3-Diazaspiro[4.5]decane-2,4-dione
5,5-Pentamethylenehydantoin
5,5'-Cyclohexanespirohydantoin
Hydantoin, pentamethylene-
Ba 2840
5,5-Pentamethylenespirohydantoin
Hydantoin, 5,5-pentamethylene-
NSC 16617
Spiro(cyclohexane-1,5'-hydantoin)
NSC 172110
Cyclohexane-(spiro-5)-hydantoin
EINECS 211-868-7
BRN 0145234
Pentamethylenehydantoin
AI3-03731
1,3-DIAZASPIRO(4.5)DECANE-2,4-DIONE
DTXSID5061033
5-24-07-00294 (Beilstein Handbook Reference)
Spiro[cyclohexane-1,5'-hydantoin]
DTXCID5046643
211-868-7
nernexmeyqffhu-uhfffaoysa-n
702-62-5
Cyclohexanespiro-5'-hydantoin
CHEMBL79885
MLS002638496
NSC16617
1,3-diazaspiro[4,5]decane-2,4-dione
Hydantoin,5-pentamethylene-
2,4-diazaspiro[4.5]decane-1,3-dione
MFCD00022404
Maybridge1_004385
Oprea1_691915
5,5-Cyclohexanespirohydantoin
SCHEMBL351324
HMS553P09
5, 5-Pentamethylenespirohydantoin
HMS3093P11
BDBM50022450
NSC-16617
NSC172110
STL227712
{Spiro[cyclohexane-1,5'-hydantoin]}
AKOS000199411
AB11072
NSC-172110
PS-3142
SMR001547970
{1,3-Diazaspiro[4.5]decane-2,} 4-dione
CS-0084878
EU-0000868
NS00037031
EN300-16720
AE-641/00682003
SR-01000394795
SR-01000394795-1
Z56757184