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1,3-Dihydroxyurea

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Identification
Molecular formula
C1H4N2O3
CAS number
556-40-1
IUPAC name
1,3-dihydroxyurea
State
State

At room temperature, 1,3-dihydroxyurea is in a solid state. It is generally stable under normal conditions, but care should be taken when handling the compound to avoid contamination or unwanted reactions.

Melting point (Celsius)
78.00
Melting point (Kelvin)
351.00
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.00
General information
Molecular weight
90.06g/mol
Molar mass
90.0640g/mol
Density
2.0200g/cm3
Appearence

1,3-Dihydroxyurea typically appears as a white crystalline solid. The compound may be used in laboratory settings and can form distinct crystals when purified.

Comment on solubility

Solubility of 1,3-dihydroxyurea

1,3-dihydroxyurea, known for its potential in various applications, exhibits interesting solubility properties that are crucial for its practical use. This compound is generally considered to be:

  • Soluble in water: 1,3-dihydroxyurea is highly soluble in aqueous solutions, making it suitable for various biological and chemical processes.
  • Moderate solubility in organic solvents: It can also dissolve in certain organic solvents, although this may vary depending on the specific solvent properties.
  • pH-dependent: Its solubility can be influenced by the pH of the solution, allowing for manipulation in different environments.

To quote, "The solubility characteristics of 1,3-dihydroxyurea allow it to effectively interact in biological systems," emphasizing its role in pharmacological contexts.

This combination of solubility makes 1,3-dihydroxyurea a versatile compound, essential for its functionality and adaptability across different media.

Interesting facts

Interesting Facts about 1,3-Dihydroxyurea

1,3-Dihydroxyurea is a fascinating compound with significant implications in various fields, particularly in medicinal chemistry and biochemistry. Below are some intriguing insights into this versatile molecule:

  • Pharmacological Applications: 1,3-Dihydroxyurea is primarily known for its role as a therapeutic agent in treating certain types of cancer, notably chronic myelogenous leukemia (CML). Its ability to inhibit DNA synthesis makes it a vital compound in oncology.
  • Mechanism of Action: This compound acts by reducing the levels of ribonucleotide reductase activity, which is crucial for DNA synthesis. By doing so, it halts the proliferation of rapidly dividing cancer cells.
  • Research Potential: Beyond its current applications, researchers are exploring the potential of 1,3-dihydroxyurea in other disorders, such as sickle cell disease and certain skin conditions, showcasing its versatility in therapeutic settings.
  • Synthesis: The compound can be synthesized through various chemical methods, which often involve the modification of urea in the presence of reducing agents. Understanding its synthetic pathways is key for industrial applications.
  • Historical Context: 1,3-Dihydroxyurea has a rich history in pharmaceutical development, with its initial discoveries paving the way for newer formulations that enhance its efficacy and reduce side effects.

In the words of renowned chemists, "The exploration of compounds like 1,3-Dihydroxyurea not only advances our pharmacological arsenal but also deepens our understanding of cellular processes." This compound exemplifies the intersection of organic chemistry and therapeutic innovation, making it a subject of ongoing study and fascination.

Synonyms
DIHYDROXYUREA
Urea, N,N'-dihydroxy-
N,N'-dihydroxyurea
N',N-Dihydroxyurea
UNII-16UJ4Q60DX
NSC 528762
16UJ4Q60DX
NSC-528762
DIHYDROXYUREA, 1,3-
DTXSID9074852
dihydrourea
DTXCID7046174
Urea, N,N'-dihydroxy-(9CI)
1,3-Dihydroxyurea
686-68-0
Urea, 1,3-dihydroxy-
hydroxyaminoketone
Urea,3-dihydroxy-
NSC528762
Urea,N'-dihydroxy-
Urea, n,n-dihydroxy-
DS-012528
Q27251839