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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
13-ethyl-3-methoxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol
State
State
Estradiol is generally found in a solid state at room temperature, usually in the form of a fine crystalline powder.
Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
377.94
Boiling point (Kelvin)
651.09
General information
Molecular weight
272.38g/mol
Molar mass
272.3810g/mol
Density
1.1060g/cm3
Appearence

Estradiol is a white to creamy-white, odorless crystalline powder. It is poorly soluble in water but soluble in alcohol, chloroform, dioxane, ether, and vegetable oils.

Comment on solubility

Solubility of 13-ethyl-3-methoxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol

The solubility of 13-ethyl-3-methoxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol can often be a complex topic due to its intricate molecular structure. Here are some important points regarding its solubility:

  • Solvent Compatibility: This compound is likely to exhibit different solubility profiles in various solvents. It may be more soluble in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), and certain hydrocarbons.
  • Polarity Influences: Given the presence of functional groups, the solubility may be influenced by the polarity of the compound. Generally, hydrocarbons are less polar and can show limited solubility in polar solvents like water.
  • Temperature Dependency: As with many organic compounds, solubility can increase with temperature. Thus, heating the solvent may help in dissolving the compound more effectively.
  • Crystallization Risks: When attempting to dissolve this compound, be aware that it may crystallize out of solution upon cooling, especially if it was initially dissolved at elevated temperatures.

In summary, the solubility of this compound is a multifaceted property influenced by several factors including the choice of solvent, temperature, and molecular interactions. As always, empirical tests are recommended to determine precise solubility characteristics.

Interesting facts

Interesting Facts about 13-ethyl-3-methoxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol

This intriguing compound belongs to the family of steroids and is specifically categorized as a steroidal alcohol due to the presence of a hydroxyl group (-OH). Here are some fascinating points about this compound:

  • Source and Isolation: This compound can be isolated from various natural sources, including plants and animal tissues, showcasing nature's remarkable ability to synthesize complex molecules.
  • Biological Significance: Compounds like this one often exhibit important biological activities. They can act as hormones or precursors to hormones, playing a vital role in various physiological processes such as metabolism and immune response.
  • Synthesis: The organic synthesis of such compounds can be quite intricate, involving multiple steps of functional group transformations and stereochemistry considerations. Chemists utilize methods like catalytic hydrogenation and functionalization to achieve the desired structural features.
  • Pharmaceutical Applications: Many steroidal compounds are investigated for their therapeutic potential. Steroidal alcohols, due to their unique structure, can interact with biological receptors, leading to a variety of pharmacological effects.
  • Research Interest: This compound serves as a subject of ongoing research in areas like biochemistry and medicinal chemistry, where its interactions and effects are studied in detail to uncover potential new drugs.
  • Cultural Impact: As part of the broader steroid family, this compound has implications in sports performance, health, and wellness discussions, especially in terms of its anabolic properties.

In summary, 13-ethyl-3-methoxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-ol stands as a notable example of the complexity found in chemical compounds derived from steroids, highlighting the intricate balance between structure and function in biological systems.