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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-3,17-diol
State
State

At room temperature, estradiol is in solid state.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
431.50
Boiling point (Kelvin)
704.65
General information
Molecular weight
272.38g/mol
Molar mass
272.3830g/mol
Density
1.1650g/cm3
Appearence

Estradiol is a white to off-white crystalline powder. It is odorless and is usually supplied in micronized form for better absorption when used in medical applications.

Comment on solubility

Solubility of 13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-3,17-diol

The solubility of 13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-3,17-diol in various solvents can be intriguing due to its complex structure. The amphiphilic nature of this compound generally affects its interaction with solvents.

Factors Influencing Solubility:

  • Polarity: The presence of hydroxyl (–OH) groups typically increases the solubility of organic compounds in polar solvents, such as water.
  • Hydrophobic Interactions: The hydrocarbon portions of the molecule may lead to greater solubility in nonpolar solvents like hexane or toluene.
  • Hydrogen Bonding: The capability to form hydrogen bonds can enhance solubility in polar solvents, particularly when interacting with water.

As a result, you might observe the following solubility trends:

  1. Higher solubility in alcohols and ethers due to potential hydrogen bonding.
  2. Moderate solubility in water, contingent upon temperature and molecular interactions.
  3. Low solubility in nonpolar solvents, although manageable in organic solvents.

In conclusion, the solubility of this unique compound can vary widely based on environmental conditions and solvent choice. Understanding these properties allows scientists to predict its behavior in different chemical contexts.

Interesting facts

Interesting Facts about 13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-3,17-diol

This compound is a fascinating derivative of cyclopenta[a]phenanthrene and presents intriguing features for both chemists and biochemists alike. Here are some noteworthy aspects:

  • Structure and Complexity: The compound possesses a unique polycyclic structure that contributes to its intriguing chemical reactivity and biological activity. The presence of multiple rings offers a plethora of functionalities for potential interactions.
  • Natural Products: Many compounds with similar structures are found in nature, often playing important roles in biological processes. Studying this compound can shed light on the biosynthesis of steroidal derivatives.
  • Potential Applications: The presence of hydroxyl (-OH) functional groups can influence the compound's biological properties, making it significant in medicinal chemistry. Research may indicate potential therapeutic roles, particularly in hormone-related pathways.
  • Research Opportunities: Scientists are continuously exploring the implications of such compounds in drug development. Their structural complexity might be a key to discovering novel therapeutic agents.
  • Historical Context: Compounds of this nature have been pivotal in the development of our understanding of sterols and their derivatives, leading to significant advancements in biochemistry and pharmacology.

As we delve deeper into the study of 13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-3,17-diol, we uncover its potential connections to larger biochemicals that are crucial for cellular function and interaction. The ongoing research surrounding this compound highlights the dynamic nature of chemistry and the continuous quest for knowledge in the realm of molecular science.

Synonyms
.beta.-Dihydroequilenin
350819-99-7
17?-Dihydro equilenin
17.beta.-dihydroequilenin
RYWZPRVUQHMJFF-UHFFFAOYSA-N
GAA63999
Estra-1,3,5,7,9-pentaene-3,17.beta.-diol
Estra-1,3,5(10),6,8-pentaene-3,17-diol #
Estra-1,3,5(10),6,8-pentaene-3,17.beta.-diol
Estra-1,3,5,7,9-pentaene-3,17-diol, (17.beta.)-