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Tibolone

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Identification
Molecular formula
C21H28O2
CAS number
5630-53-5
IUPAC name
13-methyl-17-tetrahydropyran-2-yloxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol
State
State

At room temperature, Tibolone is in a solid state. It exists as a stable crystalline powder, making it suitable for formulation in pharmaceutical applications.

Melting point (Celsius)
175.00
Melting point (Kelvin)
448.15
Boiling point (Celsius)
324.50
Boiling point (Kelvin)
597.65
General information
Molecular weight
312.45g/mol
Molar mass
0.0000g/mol
Density
1.1327g/cm3
Appearence

Tibolone typically appears as a white or almost white crystalline powder. It is odorless, and its crystalline nature can be observed through microscopy where well-defined crystals can be seen.

Comment on solubility

Solubility of 13-methyl-17-tetrahydropyran-2-yloxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol

The solubility of 13-methyl-17-tetrahydropyran-2-yloxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol can be influenced by several factors, including its complex molecular structure and the presence of functional groups. Here are some key points to consider:

  • Polarity: The presence of hydroxyl (-OH) groups generally enhances solubility in polar solvents like water, while non-polar components may result in limited solubility in these solvents.
  • Solvent Compatibility: This compound may exhibit better solubility in organic solvents such as ethanol, methanol, or dichloromethane compared to water due to its larger hydrocarbons.
  • Hydrogen Bonding: The hydrogen bonds formed with water can significantly affect solubility, depending on the balance between hydrophilic and hydrophobic regions of the molecule.
  • Temperature Dependency: As with many organic compounds, increasing temperature may improve solubility, making it essential to conduct experiments under various conditions.

"Solubility is a fundamental property that defines how compounds interact within different environments." Understanding the solubility of this compound is essential for applications in medicinal chemistry and materials science, where solubility plays a crucial role in bioavailability and processing.

Interesting facts

Interesting Facts about 13-methyl-17-tetrahydropyran-2-yloxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol

This compound represents an intriguing example of organic chemistry, specifically within the realm of steroids and complex polycyclic compounds. Its structure showcases a high level of stereochemistry and functional group diversification, contributing to its potential biological significance.

Key Characteristics:

  • Steroid-like Structure: The presence of the steroidal framework hints at potential hormonal activities, making this compound of interest in medicinal chemistry and endocrinology.
  • Functional Groups: With a tetrahydropyran moiety, it presents unique reactivity and could function as a versatile precursor in synthetic organic chemistry.
  • Biological Activity: Compounds of similar structure often exhibit a range of biological activities, including anti-inflammatory and anticancer effects, inviting further exploration.
  • Complexity: The intricate arrangement of carbon atoms and stereochemistry not only challenges chemists but also offers fascinating insights into molecular interactions.

Research into compounds like this one is essential to drug discovery, as the structure-function relationship can reveal mechanisms of action and lead to the synthesis of novel therapeutic agents. As noted by many chemists, "The beauty of organic chemistry lies in its elegance and complexity; every structure tells a story."
Understanding such compounds can lead to breakthroughs in pharmacology and therapeutic sciences, reinforcing the importance of structural diversity in developing new medications.

Synonyms
13-methyl-17-(oxan-2-yloxy)-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol
3589-90-0
NSC-99694
NSC99694