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Estriol

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Identification
Molecular formula
C18H24O3
CAS number
50-27-1
IUPAC name
13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol
State
State

At room temperature, estriol is in a solid state. It is stable under ambient conditions and is usually stored in tightly sealed containers to prevent moisture absorption.

Melting point (Celsius)
280.50
Melting point (Kelvin)
553.65
Boiling point (Celsius)
553.00
Boiling point (Kelvin)
826.15
General information
Molecular weight
288.38g/mol
Molar mass
288.3810g/mol
Density
1.2300g/cm3
Appearence

Estriol is typically found as a white or nearly white crystalline powder. It is odorless and has a slightly bitter taste. The compound is used in pharmaceuticals, often in the form of micronized powder to ensure better absorption when compounded into tablets or other formulations.

Comment on solubility

Solubility of 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol

The solubility of 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol (C18H24O3) can be described as follows:

  • Organic Solvents: This compound is expected to have moderate solubility in organic solvents such as ethanol and methanol due to its hydrophobic hydrocarbon structure.
  • Water Solubility: Given the significant hydrophobic character and the presence of hydroxyl groups, the water solubility is likely to be low.
    The overall structure contributes to a poor interaction with polar water molecules.
  • pH Dependency: The solubility may vary with pH, as the degree of protonation of hydroxyl groups in different environments can influence the compound's interaction with solvents.

Overall, while 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol may have some solubility in certain organic solvents, its solubility in water remains limited. This underscores the importance of considering both structural aspects and environmental conditions when evaluating solubility.

Interesting facts

Interesting Facts about 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol

The compound 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol is an intriguing member of the class of steroids and polycyclic compounds. Its complex structure and unique properties make it a subject of interest in various fields of scientific research. Below are some noteworthy aspects of this compound:

  • Synthetic Pathways: The synthesis of such polycyclic compounds often involves intricate organic reactions, including cyclization and functionalization steps that require careful control of reaction conditions.
  • Biological Activity: Compounds with similar frameworks are often investigated for their biological properties. This particular structure may exhibit interesting interactions with biological receptors, making it a target for pharmacological studies.
  • Structural Diversity: The presence of methyl groups and hydroxyl groups in its structure contributes to its chemical behavior and reactivity, potentially leading to the development of derivatives with enhanced activity.
  • Environmental Impact: Investigating the fate of such compounds in the environment can illuminate their stability and degradation pathways, especially relevant in the context of environmental chemistry and toxicology.
  • Historical Significance: Many compounds like this have historical importance due to their role in the study of natural products and their applications in medicinal chemistry, often serving as precursors to drug development.

In summary, 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol stands out in the realm of chemical compounds due to its fascinating structure and the potential it holds for both research and application in various scientific domains. As researchers continue to unravel its properties and behaviors, we can expect to see exciting developments stemming from this intriguing compound.

Synonyms
13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol
16a-Hydroxyestradiol
11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-1,2,7-triol
SMR000857236
Estra-1(10),2,4-triene-3,16,17-triol
NCIOpen2_004748
Oprea1_027407
MLS001333115
MLS001333116
Estriol-2,3,4-13C3
CHEMBL283081
SCHEMBL3426530
Estra-1,3,5(10)-triene-3,16,17-triol, (16.beta.,17.beta.)-
DTXSID10902203
CHEBI:125457
HMS2230P05
ALBB-023672
DCA86632
FAC63956
FCA72798
16-Epiestriol, >=93% (HPLC)
BBL028859
STL146317
AKOS005720798
AC-1260
16?-Hydroxy-17?-estradiol-2,4-d2
AS-13034
SY057818
3,16a,17ss-Trihydroxy-1,3,5(10)-estratriene
Q27216076
(16beta,17beta)-Estra-1,3,5(10)-Triene-3,16,17-Triol