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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
State
State

State at Room Temperature: Estradiol is generally found in a solid state at room temperature. It is a crystalline substance, commonly utilized in its solid form for various pharmaceutical applications.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
518.00
Boiling point (Kelvin)
791.15
General information
Molecular weight
272.38g/mol
Molar mass
272.3840g/mol
Density
1.1700g/cm3
Appearence

Estradiol typically appears as a white, crystalline powder. It is essentially odorless and tasteless, making it a convenient form for use in pharmaceutical preparations. Due to its crystalline nature, it can reflect light, giving it a slight sheen under illumination.

Comment on solubility

Solubility of 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

The solubility of 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol (C18H24O2) is an interesting characteristic due to its molecular structure and functional groups. Here are some key points regarding its solubility:

  • Polar vs. Non-Polar: The presence of hydroxyl groups (-OH) suggests that this compound may possess some polarity, potentially enhancing its solubility in polar solvents, such as water.
  • Hydrophobic Components: However, the large hydrocarbon structure indicates a significant hydrophobic character, which may hinder solubility in polar solvents.
  • Common Solvents: It might be expected to have better solubility in organic solvents like ethanol, methanol, or acetone due to their ability to interact with both polar and non-polar regions of the molecule.
  • Temperature Effects: As is often the case with organic compounds, temperature can significantly influence the solubility; higher temperatures typically increase solubility in organic solvents.

In summary, while the compound may dissolve moderately well in certain organic solvents due to its polar -OH groups, its overall solubility behavior is complex and may vary significantly based on the environmental conditions and choice of solvent. Thus, experimentation is essential for understanding its solubility profile fully.

Interesting facts

Interesting Facts about 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

This compound, known as a type of steroid, possesses a structure that is both intricate and fascinating. Its unique configuration points to its potential applications and significance in various biological contexts. Here are several intriguing aspects about this compound:

  • Natural Occurrence: This compound is structurally related to several naturally occurring steroids, which play vital roles in biological systems.
  • Biological Importance: Steroids are crucial in the regulation of various physiological processes, including metabolism, immune response, and reproduction.
  • Synthetic Utility: In the field of organic chemistry, the synthesis of compounds like 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol can provide insights into the complex mechanism of steroid synthesis and modification.
  • Research Implications: This compound is of interest in the study of hormonal activities and can serve as a lead compound for the development of pharmaceuticals targeting specific steroid-related pathways.
  • Structural Features: Its decahydrocyclopenta structure presents unique stereochemistry challenges that are significant for synthetic chemists to explore.

In summary, 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol is not just a chemical entity of interest; it's a gateway into understanding complex biological mechanisms, offering opportunities for innovative research and development in medicinal chemistry. Embracing its complexities could lead to significant advancements in therapeutic applications.

Synonyms
13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
5864-38-0
Estra-1,3,5(10)-triene-3,17-diol
1,3,5(10)-Estratriene-3,17 beta-diol
MFCD00003693
MFCD00064144
?-Estradiol
17beta-Estradiol-[2,3,4-13C3]
17BETA-ESTRADIOL-16,16-D2
17?-Estradiol-d4
CHEMBL412
17?-Estradiol-d5 solution
NCIOpen2_007331
SCHEMBL94610
CHEBI:95191
17916-67-5
ALBB-025799
RCA78903
WIA09345
BDBM50005414
NSC102841
AKOS015998413
NSC-102841
15-methyltetracyclo[8.7.0.0<2,7>.0<11,15>]heptadeca-2(7),3,5-triene-5,14-diol
NCGC00015422-02
NCGC00015422-03
NCGC00015422-04
LS-14666
SY017569
SY045798
NS00100142
EN300-296134
L024123
BRD-A60070924-001-01-8
Q27167000
13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol
15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-2,4,6-triene-5,14-diol
(estradiol)13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
1093411-48-3
13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol (estradiol)
13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol( Estradiol)
13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol([6,7-3H]-estradiol)
13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol(17alpha-estradiol)
13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol(17beta-estradiol)
13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol(Estradiol)
Estradiol13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol