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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,4,17-triol
State
State
Estradiol is typically found in a solid state at room temperature. It is often processed into various medicinal forms like tablets, creams, gels, or patches for hormone therapy applications.
Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
357.30
Boiling point (Kelvin)
630.45
General information
Molecular weight
272.38g/mol
Molar mass
272.3810g/mol
Density
1.2300g/cm3
Appearence

Estradiol is a white to off-white crystalline powder. It is practically odorless and is often supplied in a micronized form to increase bioavailability when administered orally.

Comment on solubility

Solubility of 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,4,17-triol (C18H24O2)

The solubility of 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,4,17-triol can provide valuable insights into its chemical behavior and potential applications. Here are some key points regarding its solubility:

  • Solvent Interaction: The compound is primarily a hydrophobic
  • Non-Polar Solvents: It is expected to exhibit significantly higher solubility in non-polar solvents such as hexane, chloroform, or benzene, given its hydrocarbon-like nature.
  • Properties of Alcohols: Solubility in organic alcohols may be moderate since the hydroxyl (–OH) groups can engage in hydrogen bonding, enhancing solubility to some extent.
  • Temperature Effects: The solubility may also vary with temperature; typically, solubility increases with temperature in most organic solvents.

In conclusion, while the solubility behavior of 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,4,17-triol is characterized by substantial non-polar characteristics, its interaction with different solvents can lead to variable outcomes, necessitating further experimental investigation to precisely determine its solubility profile.

Interesting facts

Interesting Facts about 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,4,17-triol

The compound 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,4,17-triol is a fascinating entity in the realm of organic chemistry, particularly known for its structural complexity and potential biological significance. Here are some noteworthy aspects of this compound:

  • Structural Significance: This compound features a unique polycyclic structure, which consists of multiple fused rings. This kind of architecture is characteristic of natural steroids and can impact its reactivity and interaction with biological systems.
  • Biological Relevance: Given its structure, compounds related to this class often exhibit interesting biological activity, making them subjects of investigation for pharmaceutical applications, particularly in hormone-related pathways.
  • Research Applications: Structural derivatives of this compound are often studied for their role as biochemical intermediates, which can be crucial in synthetic organic chemistry and the development of new drugs.
  • Synthesis Techniques: The synthesis of such a complex molecule demands advanced methodologies in organic chemistry. Techniques such as stereoselective synthesis, ring-closing metathesis, and other modern organic strategies are typically employed.

In conclusion, 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,4,17-triol serves as an exemplary model of how structural intricacies in organic compounds can lead to significant biological and medicinal chemistry advancements. As you delve deeper into organic synthesis and pharmacological research, compounds like this underscore the synthesis of structure and function in chemistry.

Synonyms
4-hydroxystradiol
4-Hydroxy-17?-estradiol-16,16,17-d5
SCHEMBL13123059
DTXSID30859942
WIA09338
ICX5609054
Estra-1,3,5(10)-triene-3,4,17-triol