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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
13-methyl-6,9,11,12,14,15,16,17-octahydrocyclopenta[a]phenanthrene-3,17-diol
State
State

At room temperature, estradiol is in a solid state as a crystalline powder. It is not typically volatile or prone to rapid sublimation at ambient conditions.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
510.00
Boiling point (Kelvin)
783.15
General information
Molecular weight
272.38g/mol
Molar mass
272.3840g/mol
Density
1.1698g/cm3
Appearence

Estradiol is a white or almost white crystalline powder. It is practically odorless and has a melting point characteristic of pure steroids. The powder is generally found in a fine, powdery form when prepared for pharmaceutical and research applications.

Comment on solubility

Solubility of 13-methyl-6,9,11,12,14,15,16,17-octahydrocyclopenta[a]phenanthrene-3,17-diol

The solubility of 13-methyl-6,9,11,12,14,15,16,17-octahydrocyclopenta[a]phenanthrene-3,17-diol can be understood through various factors influencing its behavior in different solvents. Here are some key points to consider:

  • Polarity: The presence of hydroxyl (-OH) groups typically enhances the polarity of compounds, often leading to increased solubility in polar solvents such as water.
  • Hydrophobic Regions: On the contrary, the large hydrophobic cyclopentaphenanthrene structure may hinder solubility in polar solvents while facilitating solubility in non-polar solvents like organic oils.
  • Hydrogen Bonding: The hydroxyl groups can engage in hydrogen bonding, which can significantly impact solubility, especially in alcohols or aqueous solutions.
  • Temperature Effects: Solubility often increases with temperature, allowing for better dissolution of solid compounds in solvents.

Overall, the solubility of 13-methyl-6,9,11,12,14,15,16,17-octahydrocyclopenta[a]phenanthrene-3,17-diol is a complex interplay of its molecular structure and the properties of the solvent. The effectiveness of dissolution will vary depending on the specific conditions applied, making solubility a fascinating aspect of this compound's characteristics.

Interesting facts

Interesting Facts about 13-methyl-6,9,11,12,14,15,16,17-octahydrocyclopenta[a]phenanthrene-3,17-diol

This fascinating compound belongs to a class of organic molecules that are known for their remarkable properties and biological significance. Here are some key points about 13-methyl-6,9,11,12,14,15,16,17-octahydrocyclopenta[a]phenanthrene-3,17-diol:

  • Biological Role: Compounds similar to this one play crucial roles as hormones and signaling molecules in various biological systems. They are vital in regulating metabolism, growth, and reproduction.
  • Synthetic Pathways: The synthesis of such complex hydrocarbons often involves intricate chemical reactions, demonstrating the ingenuity of organic chemists. These pathways may include ring closure, functional group transformations, and stereochemistry control.
  • Applications: This compound could potentially be explored for its pharmacological properties, particularly in the development of drugs targeting specific receptors in the body, given its complex configuration and functionalities.
  • Structural Significance: The unique ring structure of this molecule contributes to its overall stability and defines its chemical reactivity. The containment of multiple rings allows for interesting interactions within biological systems.
  • Research Interest: Due to its complex nature, compounds like this one are often subjects of research in fields such as medicinal chemistry, biochemistry, and toxicology, where their interactions with biological macromolecules are studied.

In summary, 13-methyl-6,9,11,12,14,15,16,17-octahydrocyclopenta[a]phenanthrene-3,17-diol is an intriguing compound that enhances our understanding of organic chemistry and its implications in biological systems. As we delve deeper into its properties and potential applications, we uncover the extensive possibilities that lie within this complex structure.

Synonyms
Dihydroequilin
.alpha.-Hydroequiline
17 .alpha.-Dihydroequilin
Estra-1,3,5(10),7-tetraene-3,17-diol, (17.alpha.)-
17 alpha-dihydroequilin
DIHYDROEQUILIN [MI]
17-dihydroequilin
alpha-Hydroequiline
17alpha-dihydroequilein
651-55-8
nllmjanwpuqqta-uhfffaoysa-n
ESTRA-1,3,5(10),7-TETRAENE-3,17BETA-DIOL
NSC-12170
17beta-DIHYDROEQUILIN-16,16,17-D3
SCHEMBL666926
NSC12170
Estra-1(10),2,4,7-tetraene-3,17-diol #