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Isatin

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Identification
Molecular formula
C9H7NO2
CAS number
91-56-5
IUPAC name
1,3,3-trimethylindolin-2-one
State
State

At room temperature, Isatin is in a solid state and can be observed as crystalline powder of varying shades from red-orange to light brown.

Melting point (Celsius)
200.00
Melting point (Kelvin)
473.20
Boiling point (Celsius)
362.50
Boiling point (Kelvin)
635.60
General information
Molecular weight
147.17g/mol
Molar mass
147.1740g/mol
Density
1.2300g/cm3
Appearence

Isatin appears as a red-orange to brown crystalline solid. It is known for its vibrant coloration and distinct crystalline form.

Comment on solubility

Solubility of 1,3,3-Trimethylindolin-2-one

1,3,3-Trimethylindolin-2-one, a compound known for its unique structure, has specific solubility characteristics worth discussing. Understanding the solubility of this compound aids in its application across various fields, particularly in organic synthesis and biochemical studies.

The solubility of 1,3,3-trimethylindolin-2-one can be summarized as follows:

  • Solvents: This compound is generally soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO), which are often used for its dissolution.
  • Water: Its solubility in water is relatively low, making it a challenge for applications requiring aqueous solutions.
  • Influencing Factors: Factors such as temperature and pH can affect the solubility, with higher temperatures typically improving solubility in organic solvents.

In summary, while 1,3,3-trimethylindolin-2-one demonstrates a pronounced solubility in organic environments, it shows limited solubility in polar solvents like water. This characteristic is essential when considering the compound's reactivity and utility in chemical processes.

Interesting facts

Interesting Facts about 1,3,3-trimethylindolin-2-one

1,3,3-trimethylindolin-2-one is a fascinating compound that belongs to the family of indole derivatives, which are widely recognized for their diverse biological activities and applications. Here are some key highlights that showcase the significance and properties of this compound:

  • Structural Characteristics: The compound features a unique indolin-2-one core structure, which consists of a bicyclic system. The presence of three methyl groups at the 1 and 3 positions enhances its steric and electronic properties, making it an attractive candidate for various chemical reactions.
  • Biological Activity: Many indole derivatives, including 1,3,3-trimethylindolin-2-one, exhibit a wide array of biological activities such as anti-inflammatory, antioxidant, and anticancer properties. This compound has generated interest in medicinal chemistry for its potential therapeutic applications.
  • Synthetic Utility: The compound serves as a valuable building block in organic synthesis. Its ability to undergo further transformations allows chemists to explore new derivatives and modify its properties for specific uses.
  • Pharmaceutical Research: In the field of drug discovery, 1,3,3-trimethylindolin-2-one and its analogs are subjects of investigation for their potential use in treating neurodegenerative diseases, such as Alzheimer’s disease, due to their favorable interactions with biological targets.
  • Natural Occurrence: Compounds structurally related to 1,3,3-trimethylindolin-2-one can be found in various natural sources, leading researchers to study their ecological roles and potential benefits in environmental chemistry.

In summary, the intrigue surrounding 1,3,3-trimethylindolin-2-one lies in its multifaceted nature as it bridges the fields of synthetic organic chemistry, medicinal research, and natural product chemistry. Ongoing studies are likely to unlock even more secrets of this compound that could lead to novel advancements in science and industry.

Synonyms
2-Indolinone, 1,3,3-trimethyl-
2H-Indol-2-one, 1,3-dihydro-1,3,3-trimethyl-
1,3,3-trimethylindol-2-one
1,3,3-Trimethyloxindole
DTXSID50174048
DTXCID3096539
RefChem:87643
RFJITKCIMOLCNP-UHFFFAOYSA-N
20200-86-6
1,3,3-trimethylindolin-2-one
1,3,3-TRIMETHYL-2,3-DIHYDRO-1H-INDOL-2-ONE
1,3,3-Trimethyl-2,3-dihydro-1H-indole-2-one
MFCD00463901
SCHEMBL1260714
SCHEMBL1450305
SCHEMBL1450869
SCHEMBL9028090
SCHEMBL31238640
1,3,3-trimethyl-1H-indol-2-one
AKOS022666919
SB65932
DB-354161
F98095
1,3,3-Trimethyl-1,3-dihydro-2H-indol-2-one
1,3,3-Trimethyl-1,3-dihydro-2H-indol-2-one #