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1,3,4-thiadiazol-2-amine

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Identification
Molecular formula
C2H3N3S
CAS number
5724-02-5
IUPAC name
1,3,4-thiadiazol-2-amine
State
State
At room temperature, 1,3,4-thiadiazol-2-amine is typically found as a solid.
Melting point (Celsius)
115.00
Melting point (Kelvin)
388.00
Boiling point (Celsius)
266.00
Boiling point (Kelvin)
539.00
General information
Molecular weight
101.13g/mol
Molar mass
101.1260g/mol
Density
1.4370g/cm3
Appearence
1,3,4-thiadiazol-2-amine is a compound that in its pure form, can be a crystalline solid. The color of the compound may range from white to off-white, depending on the purity and form.
Comment on solubility

Solubility of 1,3,4-Thiadiazol-2-amine

When examining the solubility of 1,3,4-thiadiazol-2-amine, it's important to consider various factors that influence its ability to dissolve in different solvents. Here are some key points regarding its solubility:

  • Polarity: The presence of the amino group (-NH2) contributes to the polarity of the molecule, enhancing its solubility in polar solvents such as water.
  • Hydrogen Bonding: The amino group allows for the formation of hydrogen bonds with solvent molecules, which can increase solubility in polar media.
  • Solvent Effects: 1,3,4-thiadiazol-2-amine shows varying solubility in different solvents; it may be more soluble in alcohols and less soluble in non-polar solvents like hexane.
  • Concentration: Higher concentrations of the compound can sometimes lead to precipitation, indicating solubility limits.
  • Temperature Influence: As with many compounds, an increase in temperature generally enhances solubility, allowing for greater dissolution rates.

Understanding these aspects of solubility not only helps predict the behavior of 1,3,4-thiadiazol-2-amine in various chemical reactions and applications but also aids in the design of experiments involving this compound.

Interesting facts

Interesting Facts about 1,3,4-Thiadiazol-2-amine

The compound 1,3,4-thiadiazol-2-amine is a fascinating member of the thiadiazole family, characterized by its five-membered heterocyclic structure that incorporates both nitrogen and sulfur atoms. This unique arrangement leads to various intriguing properties and applications in the realm of chemistry and beyond.

Chemical Structure and Properties

  • Heterocyclic Compound: The presence of sulfur and nitrogen in the ring system makes thiadiazoles particularly interesting for their reactivity and ability to form diverse derivatives.
  • Biological Activity: Compounds like 1,3,4-thiadiazol-2-amine have shown promise in medicinal chemistry, exhibiting a range of biological activities including antimicrobial and anticancer properties.
  • Coordination Chemistry: This compound can act as a ligand in coordination chemistry, forming complexes with metal ions, which can be used in various chemical processes and catalysis.

Applications and Uses

  • Agricultural Chemistry: Derivatives of thiadiazole compounds are utilized in the development of agricultural pesticides and fungicides, offering solutions for crop protection against pests and diseases.
  • Pharmaceuticals: Research is ongoing into the use of 1,3,4-thiadiazol-2-amine and its derivatives as potential therapeutic agents in treating conditions such as inflammation and infections.

Research Significance

The study of compounds like 1,3,4-thiadiazol-2-amine contributes significantly to the field of heterocyclic chemistry. Researchers are fascinated by its ability to act as a precursor for the synthesis of more complex molecules, enhancing its desirability in synthetic pathways. "Thiadiazoles are a unique class of compounds that bridge the gap between organics and metals," notes one researcher in the field, highlighting their versatility.

In summary, 1,3,4-thiadiazol-2-amine not only reflects the beauty of heterocyclic chemistry but also offers exciting avenues for research and application across multiple industries. Its intriguing structure and potential make it a compound worthy of attention in scientific study.

Synonyms
2-Amino-1,3,4-thiadiazole
1,3,4-Thiadiazol-2-amine
Aminothiadiazole
Aminothiadazole
NSC 4728
TF 128
[1,3,4]Thiadiazol-2-ylamine
1,3,4-thiadiazol-2-ylamine
1,3,4-THIADIAZOLE, 2-AMINO-
NSC4728
EINECS 223-657-7
UNII-6L41AOK74P
1,3,4-Thiadiazole-2-Amine
BRN 0107135
AI3-50581
QUKGLNCXGVWCJX-UHFFFAOYSA-
DTXSID50193113
4-27-00-08053 (Beilstein Handbook Reference)
TF-128
(1,3,4)Thiadiazol-2-ylamine
Amino 134-Thiadiazole
1,3, 4-Thiadiazol-2-amine
DTXCID60115604
1,3, 4-Thiadiazole, 2-amino-
1,3, 4-Thiadiazol-2-amine (9CI)
1,3, 4-Thiadiazole, 2-Amino-(8CI)
inchi=1/c2h3n3s/c3-2-5-4-1-6-2/h1h,(h2,3,5)
qukglncxgvwcjx-uhfffaoysa-n
4005-51-0
ATDA
FDA 0084
NSC-4728
X 26
MFCD00003107
6L41AOK74P
2-Amino-1-thia-3,4-diazole
CHEMBL1650237
1,4-Thiadiazol-2-amine
2-Amino-1,4-thiadiazole
NCIMech_000679
amino-[1,3,4]thiadiazole
imino-1,3,4-thiadiazoline
1,4-Thiadiazole, 2-amino
SCHEMBL26211
1,3,4-thiadiazol-5-amine
2-amino-1,3,4-thiadiazol
1,4-Thiadiazole, 2-amino-
1,3,4-thiadiazolium-2-aminide
3H-1,3,4-thiadiazol-2-imine
BDBM50335110
CCG-35854
STK398099
2-Amino-1,3,4-thiadiazole, 97%
AKOS000100062
CS-W019584
NF-0014
AC-25689
BP-10045
NCI60_004114
X-26
DB-020362
A1060
NS00030715
2-Amino-1 pound not3 pound not4-thiadiazole
EN300-17228
D77857
AG-670/32485054
BRD-K94837153-001-01-0
BRD-K94837153-001-02-8
Q27265082
Z56899142
F1791-0951