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Mitoxantrone

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Identification
Molecular formula
C22H28N4O6
CAS number
65271-80-9
IUPAC name
1,4-dihydroxy-5,8-bis(2-hydroxyethylamino)anthracene-9,10-dione
State
State

At room temperature, Mitoxantrone exists as a solid. It is a synthetic antineoplastic agent primarily used in chemotherapy treatments and is often dissolved in water or saline solutions for intravenous use.

Melting point (Celsius)
269.00
Melting point (Kelvin)
542.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
517.50g/mol
Molar mass
517.4250g/mol
Density
1.3000g/cm3
Appearence

Mitoxantrone usually appears as a dark blue crystalline solid. It is synthesized for pharmaceutical use and commonly found in the form of a dark blue powder when not in solution. Mitoxantrone is not typically encountered outside of its medical applications.

Comment on solubility

Solubility of 1,4-Dihydroxy-5,8-bis(2-hydroxyethylamino)anthracene-9,10-dione

The solubility of 1,4-dihydroxy-5,8-bis(2-hydroxyethylamino)anthracene-9,10-dione in various solvents presents an intriguing profile. This compound, known for its complex structure, exhibits specific solubility characteristics that are influenced by its functional groups.

Key Solubility Characteristics:

  • Polar Solvents: The presence of the hydroxyl (-OH) and amino (-NH) groups suggests that the compound is likely soluble in polar solvents such as water and ethanol. These solvents can engage in hydrogen bonding with the compound, enhancing solubility.
  • Nonpolar Solvents: In contrast, solubility in nonpolar solvents like hexane or benzene is expected to be low, owing to the hydrophilic nature of the functional groups.
  • pH Dependence: The solubility might also vary with pH levels. In more acidic or basic environments, the ionization of the amine groups could further influence the solubility in certain solvents.

Without a doubt, the intricate balance of polar and nonpolar interactions plays a crucial role in determining how well this compound will dissolve in different mediums. As noted in the literature, solubility is often a crucial property for applications in drug formulation and material science, making understanding it profoundly important.

Interesting facts

Interesting Facts about 1,4-dihydroxy-5,8-bis(2-hydroxyethylamino)anthracene-9,10-dione

This compound, often referred to as a member of the anthraquinone family, has garnered interest for its unique structure and potential applications in various fields of scientific research.

Structure and Composition

Its structure consists of:

  • Hydroxyl Groups: The two hydroxyl groups contribute to the compound's chemical reactivity and solubility.
  • Amino Substituents: The presence of bis(2-hydroxyethylamino) moieties enhances the compound's interaction with biological systems.
  • Anthracene Core: The anthracene framework provides a stable and planar structure, which is essential for its electronic properties.

Potential Applications

The diversity in applications can be attributed to its structural features:

  • Fluorescent Dyes: This compound exhibits interesting photophysical properties, making it a candidate for use in fluorescent dye applications.
  • Biological Research: Its unique functional groups facilitate interactions with biomolecules, making it useful in biological assays and drug development.
  • Material Science: Its stability and electronic properties are of interest in the development of organic electronic materials.

Scientific Insights

According to researchers, "The exploration of anthraquinones like this compound can lead to breakthroughs in photodynamic therapy and other innovative treatments." This highlights the compound's promising role in medical science.

In summary, 1,4-dihydroxy-5,8-bis(2-hydroxyethylamino)anthracene-9,10-dione is a fascinating compound not only due to its intricate molecular structure but also because of its versatile applications across multiple disciplines. Its continued study may unveil even more capabilities that could benefit science and technology in the years to come.

Synonyms
Disperse blue 7
3179-90-6
C.I. DISPERSE BLUE 7
Disperse Blue-Green
Cibacete Blue Green C
Cibacet Torquoise Blue G
CCRIS 3735
1,4-Doea-5,8-dapfa [Russian]
1,4-Doea-5,8-dapfa
EINECS 221-666-0
UNII-77Q1DI38FQ
9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis[(2-hydroxyethyl)amino]-
NSC 227207
BRN 2785044
77Q1DI38FQ
LOWADENE BLUE 7
1,4-Dihydroxy-5,8-bis((2-hydroxyethyl)amino)anthraquinone
NSC-227207
CI DISPERSE BLUE 7
9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis((2-hydroxyethyl)amino)-
1,4-Dioxyethylamino-5,8-dioxyanthraquinone [Russian]
1,4-Dioxyethylamino-5,8-dioxyanthraquinone
LOWADENE BLUE 62500
DTXSID8025208
1,4-Bis((beta-hydroxyethyl)amino)-5,8-dihydroxyanthraquinone
Anthraquinone, 1,4-bis((2-hydroxyethyl)amino)-5,8-dihydroxy-
4-14-00-00930 (Beilstein Handbook Reference)
1,4-Dihydroxy-5,8-bis[(2-hydroxyethyl)amino]anthraquinone
DISPERSOL BLUE 7G
DTXCID105208
DISPERSE BLUE 7 [INCI]
INTERCHEM DISPERSE GREEN BLUE ALFH
1,4-DIETHANOLAMINO-5,8-DIHYDROXYANTHRAQUINONE
1,4-BIS(BETA-HYDROXYETHYLAMINO)-5,8-DIHYDROXYANTHRAQUINONE
whpnhqrwwmlkpj-uhfffaoysa-n
Celliton Fast Blue Green B
Artisil Blue Green GP
Palanil Blue 7G
Samaron Blue 5G
Nacelan Blue CBG
Fenacet Fast Turquoise B
Setacyl Blue 6GN
Disperse Blue Green
Nyloquinone Blue 4J
Amacel Green Blue B
Amacel Green Blue G
Dispersive Blue-Green
Duranol Blue Green B
Celliton Blue Green B
Perliton Blue Green B
Supracet Blue Green B
Cibacet Blue Green CB
Terasil Blue Green CB
Seriplas Glue Green BW
Acetate Turquoise Blue B
Celutate Green Blue BGH
Cibacet Turquoise Blue G
Setacyl Turquoise Blue G
Terasil Turquoise Blue G
Cilla Fast Blue Green B
Setacyl Blue Green P-BS
Celanthrene Fast Blue 2G
C.I. Solvent Blue 69
Setacyl Turquoise Blue GD
Cibacet Turquoise Blue 2G
Cibacet Turquoise Blue 4G
Setacyl Turquoise Blue 2G
Setacyl Turquoise Blue 4G
Serisol Fast Blue Green B
Supracet Fast Green Blue B
Esteroquinone Light Blue 4JL
Diacelliton Fast Blue Green B
Duranol Printing Blue Green B
Miketon Fast Turquoise Blue G
Celliton Fast Blue Green BA-CF
Acetoquinone Light Green Blue JL
Interchem Acetate Green Blue ALF
Interchem Hisperse Green Blue ALFH
1,4-dihydroxy-5,8-bis(2-hydroxyethylamino)anthracene-9,10-dione
C.I. 62500
Anthraquinone, 1,4-dihydroxy-5,8-bis((2-hydroxyethyl)amino)-
1,4-DiOH-5,8-bis(2-OHethyl)aminoanthraquinone
Cibacet Blue Green C
Seriplas Blue Green BW
Serisol Fast Blue Green BW
5,8-Dihydroxy-1,4-dihydroxyethylaminoanthraquinone
1,8-dapfa
1,4-Bis((2-hydroxyethyl)amino)-5,8-dihydroxyanthraquinone
5,8-Dihydroxy-1,4-bis((2-hydroxyethyl)amino)anthraquinone
1,4-Dihydroxy-5,8-bis((2-hydroxyethyl)amino)-9,10-anthracenedione
BGH
SCHEMBL497032
CHEMBL3248529
HY-D0348
NSC227207
5,4-(dihydroxyethyl)aminoanthraquinone
AKOS015903253
FD182043
1,8-bis[(2-hydroxyethyl)amino]anthraquinone
5,4-bis[(2-hydroxyethyl)amino]anthraquinone
CS-0010353
Disperse Blue 7 100 microg/mL in Methanol
NS00013636
WLN: L C666 BV IVJ DQ GQ KM2Q NM2Q
1,4-DiOH-5,8-bis[(2-OHethyl)amino]anthraquinone
9, 1,4-dihydroxy-5,8-bis[(2-hydroxyethyl)amino]-
Q27266599
Anthraquinone,4-bis[(2-hydroxyethyl)amino]-5,8-dihydroxy-
Anthraquinone,4-dihydroxy-5,8-bis[(2-hydroxyethyl)amino]-
1,4-Dihydroxy-5,8-bis((2-hydroxyethyl)amino)anthracene-9,10-dione
1,4-dihydroxy-5,8-bis[(2-hydroxyethyl)amino]anthra-9,10-quinone