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1,4,5,6-tetrahydropyrimidine-2-thiol

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Identification
Molecular formula
C4H8N2S
CAS number
13991-43-0
IUPAC name
1,4,5,6-tetrahydropyrimidine-2-thiol
State
State
Solid at room temperature.
Melting point (Celsius)
120.00
Melting point (Kelvin)
393.15
Boiling point (Celsius)
280.00
Boiling point (Kelvin)
553.15
General information
Molecular weight
116.18g/mol
Molar mass
116.1770g/mol
Density
1.1500g/cm3
Appearence

1,4,5,6-tetrahydropyrimidine-2-thiol is generally observed as a white to off-white crystalline powder. Its crystalline nature is often indicative of a compound of relative purity.

Comment on solubility

Solubility of 1,4,5,6-Tetrahydropyrimidine-2-thiol

1,4,5,6-Tetrahydropyrimidine-2-thiol exhibits notable solubility characteristics that can be summarized as follows:

  • Polarity: Being a thiol compound, it possesses a polar -SH (sulfhydryl) group which can interact favorably with polar solvents.
  • Solvents: This compound is generally soluble in water, with enhanced solubility in organic solvents such as ethanol and dimethyl sulfoxide (DMSO).
  • pH Influence: The solubility can be affected by pH levels, as the protonation state of the thiol group may influence its interactions with solvents.

In conclusion, 1,4,5,6-tetrahydropyrimidine-2-thiol's solubility profile illustrates its versatility, allowing it to dissolve effectively in various solvents, thus broadening its utility in chemical applications. Its polar nature combined with the presence of the thiol group enhances its interaction with water and polar solvents,
highlighting the significance of functional group properties in determining solubility.

Interesting facts

Interesting Facts about 1,4,5,6-Tetrahydropyrimidine-2-thiol

1,4,5,6-tetrahydropyrimidine-2-thiol is a fascinating organic compound that belongs to the class of pyrimidines, which are six-membered aromatic rings containing nitrogen atoms. This compound has numerous intriguing characteristics and potential applications, which are worth exploring:

  • Biological Relevance: Compounds based on pyrimidine structures are often found in biological systems, including nucleic acids such as RNA and DNA. The presence of the thiol group makes this compound particularly interesting for studying biochemical interactions.
  • Pharmaceutical Potential: Research has indicated that compounds similar to 1,4,5,6-tetrahydropyrimidine-2-thiol might possess anti-inflammatory and anti-cancer properties, making them suitable candidates for drug development.
  • Synthetic Pathways: This compound can be synthesized through various chemical reactions, typically involving the condensation of carbonyl compounds and amines, which is an essential reaction in organic chemistry.
  • Reactivity: The thiol group (-SH) confers unique chemical reactivity and properties, such as nucleophilicity, which can be harnessed in synthetic applications, including the formation of disulfides and other derivatives.
  • Research Significance: Ongoing studies in medicinal chemistry and biochemistry continue to unveil the compound's potential utility in treating various conditions, reflecting the compound's significance in contemporary scientific research.

As a valuable subject of study and innovation, 1,4,5,6-tetrahydropyrimidine-2-thiol exemplifies the interconnected nature of chemical compounds and their roles in biological systems, providing insightful avenues for further exploration.