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Metamizole

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Identification
Molecular formula
C13H17N3O2
CAS number
68-89-3
IUPAC name
1,5-dimethyl-4-(methylamino)-2-phenyl-pyrazol-3-one
State
State

At room temperature, Metamizole is in a solid state. It is usually found as a crystalline powder that is stable under standard room conditions.

Melting point (Celsius)
179.00
Melting point (Kelvin)
452.15
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.15
General information
Molecular weight
311.36g/mol
Molar mass
311.3640g/mol
Density
1.3500g/cm3
Appearence

Metamizole typically appears as a white to slightly yellowish crystalline powder. It is often supplied in the form of tablets, suppositories, and injections for medical use. The compound may exhibit slight hygroscopic properties, which means it can absorb moisture from the air, causing it to clump or form a pasty consistency when exposed to high humidity levels. Its crystalline form can reflect light, giving it a slightly shiny appearance.

Comment on solubility

Solubility of 1,5-dimethyl-4-(methylamino)-2-phenyl-pyrazol-3-one

The solubility of 1,5-dimethyl-4-(methylamino)-2-phenyl-pyrazol-3-one, a complex organic compound, can be quite intriguing. Here are some key points to consider regarding its solubility:

  • Polarity: The presence of both methyl and amino groups may contribute to the compound's overall polarity, potentially enhancing its solubility in polar solvents.
  • Solvent Influence: This compound is likely more soluble in solvents such as water and methanol, but its solubility can greatly vary based on temperature and pH.
  • Hydrogen Bonding: The amino group may engage in hydrogen bonding, which typically increases solubility in polar solvents as it allows for better interaction with solvent molecules.
  • Practical Implications: For practical applications, understanding the solubility is essential, particularly in pharmaceutical contexts where solubility affects bioavailability.

In summary, while the solubility of 1,5-dimethyl-4-(methylamino)-2-phenyl-pyrazol-3-one can be influenced by various factors, it's important to approach its solubility on a case-by-case basis, testing with different solvents to determine the best outcome for specific uses.

Interesting facts

Exploring 1,5-Dimethyl-4-(methylamino)-2-phenyl-pyrazol-3-one

This fascinating compound is part of the pyrazolone class, a group that has intrigued chemists due to its diverse applications and interesting properties. Here are some engaging facts about 1,5-dimethyl-4-(methylamino)-2-phenyl-pyrazol-3-one:

  • Medicinal Chemistry: Compounds like this pyrazolone derivative are often investigated for their potential in the pharmaceutical industry, particularly as analgesics and anti-inflammatory agents.
  • Structure-Activity Relationships: The unique structure, characterized by the presence of both methyl and phenyl groups, provides insight into how molecular modifications can influence biological activity.
  • Research Interest: This compound is not just an academic curiosity; it has garnered attention in studies looking at pain management and molecular interactions in biological systems.
  • Electrophilic Properties: The electron-donating groups in its structure can enhance its electrophilic characteristics, making it an attractive candidate for further chemical transformation and derivatization.
  • Cross-disciplinary Applications: Beyond medicine, compounds similar to this one have been utilized in dye production and as intermediates in organic synthesis, showcasing their versatility.

As you delve deeper into the world of 1,5-dimethyl-4-(methylamino)-2-phenyl-pyrazol-3-one, remember that chemistry is not just about formulas and reactions. It's about understanding the interconnectedness of molecules and their potential to influence human health and technology!

Synonyms
Noramidopyrine
519-98-2
4-methylaminoantipyrine
4-(Methylamino)antipyrine
Methylaminoantipyrine
1,5-Dimethyl-4-(methylamino)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
N-Methylaminophenazone
Methylaminophenazone
Monomethylaminoantipyrine
N-Methylaminoantipyrine
1,5-dimethyl-4-(methylamino)-2-phenylpyrazol-3-one
ANTIPYRINE, 4-(METHYLAMINO)-
N.A.P.
3H-Pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-
N-Methyl-4-aminophenazone
EINECS 208-281-3
UNII-NER31DE951
BRN 0195234
NER31DE951
CHEBI:73261
NORAMIDOPYRINE [WHO-DD]
DTXSID80199865
5-25-14-00116 (Beilstein Handbook Reference)
METAMIZOLE SODIUM MONOHYDRATE IMPURITY C [EP IMPURITY]
1,5-DIMETHYL-4-METHYLAMINO-2-PHENYL-1,2-DIHYDRO-3H-PYRAZOL-3-ONE
METAMIZOLE SODIUM MONOHYDRATE IMPURITY C (EP IMPURITY)
DTXCID40122356
208-281-3
jilcewwztbbofs-uhfffaoysa-n
Noraminopyrine
4-Methylamino Antipyrine
4-Methylaminophenazone
4-Monomethylaminoantipyrine
1,2-Dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one
4-Monomethylaminophenazone
CHEMBL1164701
1,5-dimethyl-4-(methylamino)-2-phenyl-2,3-dihydro-1H-pyrazol-3-one
N-Methyl-4-aminoantipyrine
MFCD00447796
N-Desmethylaminopyrine
ChemDiv2_002661
4-(Methylamino)-antipyrine
Oprea1_672076
SCHEMBL537958
HMS1376I21
ALBB-010210
BDBM50360021
STK735134
AKOS003342430
FS-5885
DA-70111
PD127426
HY-135731
CS-0113885
NS00005878
C15913
EN300-10377497
Q27140411
4-(Methylamino)antipyrine 100 microg/mL in Acetonitrile
2,3-dimethyl-4-monomethylamino-1-phenyl-3-pyrazolin5-one
B0337-466650
1,5-Dimethyl-4-(methylamino)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one #
3H-pyrazol-3-one, 1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-, hydrochloride