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Rifampicin

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Identification
Molecular formula
C43H58Cl2N4O12
CAS number
13292-46-1
IUPAC name
15,30-dichloro-2,17-diazaheptacyclo[16.12.0.03,16.04,13.06,11.019,28.021,26]triaconta-1(30),3,6,8,10,13,15,18,21,23,25,28-dodecaene-5,12,20,27-tetrone
State
State

The compound is typically found as a solid at room temperature. As an antibiotic, it is often formulated into tablets or a powder for suspension for oral administration, as well as a lyophilized powder for intravenous injection. It should be stored in a tightly sealed, light-resistant container to maintain its stability.

Melting point (Celsius)
183.50
Melting point (Kelvin)
456.65
Boiling point (Celsius)
763.15
Boiling point (Kelvin)
1 036.30
General information
Molecular weight
822.95g/mol
Molar mass
822.9460g/mol
Density
1.3000g/cm3
Appearence

Rifampicin typically appears as a red-brown or orange crystalline powder. It can have a very fine texture and is known for its intense color, which is a characteristic feature of many rifamycin antibiotics.

Comment on solubility

Solubility of 15,30-dichloro-2,17-diazaheptacyclo[16.12.0.03,16.04,13.06,11.019,28.021,26]triaconta-1(30),3,6,8,10,13,15,18,21,23,25,28-dodecaene-5,12,20,27-tetrone

The solubility of this complex compound, 15,30-dichloro-2,17-diazaheptacyclo[16.12.0.03,16.04,13.06,11.019,28.021,26]triaconta-1(30),3,6,8,10,13,15,18,21,23,25,28-dodecaene-5,12,20,27-tetrone, can be quite intricate due to its unique structure. Here are some notable points regarding its solubility:

  • Solvent Interaction: The solubility of this compound is expected to be influenced by the presence of chloride substituents and nitrogen atoms in the molecular structure, which can interact differently with polar and non-polar solvents.
  • Water Solubility: Given its complex cyclic nature and presence of multiple functional groups, it may exhibit limited solubility in water, as larger organic molecules often do. However, solubility could increase with temperature.
  • Organic Solvents: This compound may demonstrate enhanced solubility in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), or acetone, which can solvate larger, non-polar structures effectively.
  • Temperature Dependence: Generally, solubility tends to increase with temperature; thus, heating organic solvents could improve the dissolution of this compound.
  • pH Influence: The solubility behavior may also vary with pH, particularly due to the dialkylamine and carbonyl functionalities that could protonate or deprotonate under different pH conditions.

In summary, while the exact solubility of 15,30-dichloro-2,17-diazaheptacyclo[16.12.0.03,16.04,13.06,11.019,28.021,26]triaconta-1(30),3,6,8,10,13,15,18,21,23,25,28-dodecaene-5,12,20,27-tetrone may require experimental validation, understanding the influence of molecular structure, solvent interactions, and environmental factors is key to predicting its behavior in solution.

Interesting facts

Interesting Facts about 15,30-Dichloro-2,17-Diazaheptacyclo[16.12.0.03,16.04,13.06,11.019,28.021,26]triaconta-1(30),3,6,8,10,13,15,18,21,23,25,28-dodecaene-5,12,20,27-tetrone

This compound, though complex in name and structure, opens up fascinating possibilities within the realm of chemical research. Here are some intriguing aspects of this unique molecule:

  • Complexity of Structure: The name itself hints at a highly intricate architecture, featuring multiple cyclic units and functional groups. This complexity often leads to interesting properties and behaviors, making it a gem for chemists.
  • Diversity of Applications: Compounds with such elaborate frameworks have potential uses in various fields, including:
    • Medicinal Chemistry: It may exhibit biological activities worth exploring for pharmaceutical applications.
    • Materials Science: Could be investigated for its utility in developing novel materials with desired physical properties.
  • Synthetic Challenges: The synthesis of such a compound is a monumental challenge that requires advanced techniques and methodologies in organic chemistry. It serves as a testament to the creativity and innovation required in modern chemistry.
  • Research Opportunities: Researchers are often inspired by complex molecules like this one, leading to new discoveries. This can include understanding reaction mechanisms or designing derivatives for enhanced activity.

In the world of chemistry, compounds like this one exemplify the intersection of complexity and creativity. As a student or a researcher, delving into its synthesis and exploring its properties can yield fruitful insights and pave the way for future breakthroughs.

Synonyms
VAT BLUE 6
130-20-1
Ahcovat Blue BCF
3,3'-Dichloroindanthrene
C.I. Vat Blue 6
D&C Blue No. 9
Alizanthrene Blue RC
5,9,14,18-Anthrazinetetrone, 7,16-dichloro-6,15-dihydro-
Navinon Blue BC
Carbanthrene Blue BCF
Dichloroindanthrone
Ponsol Blue BCS
Ponsol Blue BF
Ponsol Blue BFD
Ponsol Blue BFN
Ponsol Blue BFP
Cibanone Blue FG
Cibanone Blue GF
Paradone Blue RC
Tinon Blue GF
Tinon Blue GL
Fenan Blue BCS
Vat Green B
Blue K
Caledon Blue XRC
Benzadone Blue RC
Ponsol Blue BFDP
Ponsol Blue BFND
Vat Blue K
Cibanone Blue FGF
Cibanone Blue FGL
Solanthrene Blue B
Vat Blue KD
Fenanthren Blue BC
Fenanthren Blue BD
Indanthren Blue BC
Mikethrene Blue BC
Atic Vat Blue BC
Calcoloid Blue BLC
Calcoloid Blue BLD
Calcoloid Blue BLR
Indo Blue B-I
Helanthrene Blue BC
Indanthrene Blue BC
Nihonthrene Blue BC
Palanthrene Blue BC
Pernithrene Blue BC
Sandothrene Blue NG
Solanthrene Blue SB
Amanthrene Blue BCL
Indanthren Blue BCA
Indanthren Blue BCS
Mikethrene Blue BCS
Nyanthrene Blue BFP
Ostanthren Blue BCL
Ostanthren Blue BCS
Romantrene Blue FBC
Calcoloid Blue BLFD
Vat Fast Blue BCS
CI Vat Blue 6
Indanthrene Blue BCF
Palanthrene Blue BCA
Romanthrene Blue FBC
Sandothrene Blue NGR
Sandothrene Blue NGW
Carbanthrene Blue BCS
Carbanthrene Blue RCS
Carbanthrene Blue RBCF
Intravat Blue GF
D&C Blue 9
Solanthrene Blue F-SBA
Monolite Fast Blue 2RV
Vat Sky Blue K
Vat Sky Blue KD
3,3'-Dichloroindanthrone
7,16-Dichloroindanthrone
D and C Blue No. 9
Harmone B 79
Monolite Fast Blue 2RVSA
Navinon Brilliant Blue RCL
Carbantarene Blue BCF
Indotoner Blue B 79
Indo Blue WD 279
Vat Sky Blue KP 2F
Nihonthrene Brilliant Blue RCL
Resinated Indo Blue B 85
C.i.var blue 6
7:16-Dichloro-6:15-indanthrone
7,16-Dichlorodinaphtho[2,3-a:2',3'-h]phenazine-5,9,14,18(6H,15H)-tetraone
C.I. 69825
HSDB 2933
UNII-UBL2KQB85Q
EINECS 204-980-2
NSC 74700
BRN 0068486
CCRIS 9493
CI 69825
DTXSID9044532
Indotoner Blue B-79
CARBANTHRENE BLUE
NSC-74700
UBL2KQB85Q
Resinated Indo Blue B-85
VAT BLUE 6 [HSDB]
BLUE NO. 204
DTXCID7024532
AO204
4-24-00-02195 (Beilstein Handbook Reference)
NSC74700
INDANTHRENE, 7,16-DICHLORO-
15,30-dichloro-2,17-diazaheptacyclo[16.12.0.03,16.04,13.06,11.019,28.021,26]triaconta-1(30),3,6,8,10,13,15,18,21,23,25,28-dodecaene-5,12,20,27-tetrone
7,16-Dichloro-6,15-dihydro-5,9,14,18-anthrazinetetrone
5,9,14,18-Anthrazinetetrone, 7,16-dichloro-6,15-dihydro-,
7,16-dichloro-6,15-dihydro-5,9,14,18-anthrazine-tetrone
Indo Blue BI
dichloro[?]tetrone
MFCD00046965
Harmone B.79
Solanthrene Blue FSBA
7,16-Dichloro-6,15-dihydroanthrazine-5,9,14,18-tetrone
Indo Blue WD-279
3,3'Dichloroindanthrene
3,3'Dichloroindanthrone
7,16Dichloroindanthrone
D AND C BLUE NO 9
SCHEMBL342102
7:16Dichloro6:15indanthrone
AO204 [INCI]
Vat Blue 6 - Technical grade
CHEMBL2001164
UGCDBQWJXSAYIL-UHFFFAOYSA-N
HY-D1273
Tox21_302231
STK031750
AKOS000283016
FV41512
NCGC00255878-01
CAS-130-20-1
NCI60_041636
DB-081214
CS-0145926
NS00013526
H10897
7,16Dichloro6,15dihydro5,9,14,18anthrazinetetrone
Q27291000
5,9,14,18Anthrazinetetrone, 7,16dichloro6,15dihydro
5,14,18-Anthrazinetetrone, 7,16-dichloro-6,15-dihydro-
7,16-dichloro-6,15-dihydrodinaphtho[2,3-a:2',3'-h]phenazine-5,9,14,18-tetrone
7,16-Dichlorodinaphtho[2,3-a:2',3'-h]-phenazine-5,9,14,18(6H,15H)-tetraone
204-980-2
39456-82-1
57284-96-5
7,16-DICHLORO-6,15-DIHYDRO-DINAPHTHO(2,3-A,2',3'-H)PHENAZINE-5,9,14,18-TETRAONE
814-884-8