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Estrone

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Identification
Molecular formula
C18H22O2
CAS number
53-16-7
IUPAC name
16-ethyl-17-hydroxy-13-methyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
State
State

At room temperature, estrone is a solid. It is generally stable under recommended storage conditions.

Melting point (Celsius)
259.00
Melting point (Kelvin)
532.15
Boiling point (Celsius)
370.00
Boiling point (Kelvin)
643.15
General information
Molecular weight
270.37g/mol
Molar mass
270.3660g/mol
Density
1.2300g/cm3
Appearence

Estrone appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 16-ethyl-17-hydroxy-13-methyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one (C18H22O2)

The solubility characteristics of the compound C18H22O2, commonly known as 16-ethyl-17-hydroxy-13-methyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one, can be elucidated as follows:

  • Polarity: The presence of hydroxyl (–OH) groups typically enhances solubility in polar solvents such as water.
  • Hydrophobic Character: This compound contains a significant hydrophobic portion due to its multi-ring structure, which may limit its solubility in water.
  • Solvent Compatibility: It is likely to be more soluble in organic solvents like ethanol, methanol, and acetone.
  • Temperature Dependence: Solubility may vary with temperature; generally, an increase in temperature enhances solubility in organic solvents.

In summary, while C18H22O2 may exhibit some solubility in polar solvents due to its hydroxyl groups, its hydrophobic nature is expected to predominantly favor solubility in nonpolar organic solvents. This dual behavior is a striking feature of many organic compounds, highlighting the importance of understanding solubility principles when studying chemical behavior and reactivity.

Interesting facts

Interesting Facts about 16-Ethyl-17-hydroxy-13-methyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one

This compound, often associated with the class of steroids, boasts a complex structure that evokes significant interest in both medicinal chemistry and pharmacology. Here are some key takeaways:

  • Steroid Framework: As a compound structurally related to steroids, its framework is crucial for its biological activity. Steroids play essential roles in various physiological functions, including the regulation of metabolism and immune response.
  • Potential Medicinal Applications: Given its hydroxy and carbon chain substitutions, this compound might exhibit unique properties that could be explored in the context of drug development. Research into similar compounds has yielded promising results in the treatment of conditions such as hormonal imbalances and certain types of cancer.
  • Natural Occurrence: Analogs of this compound are often found in nature. Understanding its biosynthesis could offer insights into its medicinal properties and ecological importance.
  • Research Status: Although not as widely studied as other steroid hormones, compounds with similar structures are subject to ongoing research, particularly in the areas of synthetic biology and pharmacognosy.
  • Safety and Toxicity: It's worth noting that investigating the safety profile and toxicity of such compounds can lead to important conclusions regarding their use in therapeutic settings.

In summary, the significance of 16-ethyl-17-hydroxy-13-methyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one goes beyond its chemical structure. It serves as a remarkable example of how complex chemical entities can lead to potential breakthroughs in medicine, urging scientists and students alike to explore the depths of its capabilities.

Synonyms
16b-Ethyl-19-nortestosterone
DTXSID10860490
16-ethyl-17-hydroxyestr-4-en-3-one