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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
(16R)-13-ethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol
State
State

At room temperature, estradiol is in a solid state.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
576.60
Boiling point (Kelvin)
849.80
General information
Molecular weight
272.38g/mol
Molar mass
272.3830g/mol
Density
1.1694g/cm3
Appearence

Estradiol appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of (16R)-13-ethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol

The solubility of (16R)-13-ethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol is a fascinating topic, particularly considering its complex molecular structure. This compound has several functional groups, which influence its interaction with solvents and, consequently, its solubility behavior.

Generally speaking, the solubility of organic compounds like this one can be influenced by several key factors:

  • Polarity: The presence of hydroxyl (–OH) groups typically increases solubility in polar solvents such as water.
  • Hydrophobicity: The bulky hydrocarbon structure may render the compound less soluble in polar solvents, making it more compatible with non-polar solvents like hexane or chloroform.
  • Intermolecular Interactions: The ability of the compound to engage in hydrogen bonding can enhance its solubility in appropriate solvents.

As a result, solubility might vary significantly based on the solvent employed. In this case, one could expect limited solubility in water but greater solubility in organic solvents, aligning with the general patterns observed in similar organic compounds.

In conclusion, while the specific solubility of (16R)-13-ethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol may require empirical testing for precise quantification, understanding the underlying principles can provide valuable insights. Remember, *"Like dissolves like,"* a guiding rule in solubility chemistry, can often serve as a helpful reminder in anticipating solubility outcomes!

Interesting facts

Interesting Facts about (16R)-13-ethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol

This compound, often referred to in specialized fields, is noteworthy due to its unique structural characteristics and potential biological significance. Here are some intriguing aspects:

  • Complex Structure: This compound features a polycyclic structure, which is composed of multiple fused rings. The intricate arrangement of carbon atoms makes it a fascinating subject for studies in stereochemistry and molecular interactions.
  • Biosynthetic Pathway: It is related to various natural products and may participate in biosynthetic pathways important for certain organisms, hinting at its ecological roles.
  • Potential Therapeutic Uses: Compounds of this class are under investigation for their pharmacological properties, suggesting they may possess activities related to hormone modulation or anti-inflammatory effects.
  • Stereochemistry: Its specific stereochemistry, indicated by the (16R) configuration, could impact how the compound interacts with biological receptors, making stereochemical considerations crucial in drug design.
  • Research Applications: Researchers are exploring compounds like this for various applications in medicinal chemistry, particularly in designing targeted therapies.

In summary, (16R)-13-ethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol is a compound that holds potential interest across multiple scientific domains, from synthetic chemistry to biochemistry and pharmacology. As investigations continue, it may unveil further applications and deepen our understanding of molecular interactions in biological systems.