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Cortisone

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Identification
Molecular formula
C21H28O5
CAS number
53-06-5
IUPAC name
(16S,17R)-16,17-dihydroxy-13,16-dimethyl-1,2,6,7,8,9,10,11,12,14,15,17-dodecahydrocyclopenta[a]phenanthren-3-one
State
State
Cortisone is a solid at room temperature.
Melting point (Celsius)
220.00
Melting point (Kelvin)
493.15
Boiling point (Celsius)
472.00
Boiling point (Kelvin)
745.15
General information
Molecular weight
360.45g/mol
Molar mass
360.4450g/mol
Density
1.3000g/cm3
Appearence
Cortisone appears as a white to practically white, odorless crystalline powder.
Comment on solubility

Solubility of (16S,17R)-16,17-dihydroxy-13,16-dimethyl-1,2,6,7,8,9,10,11,12,14,15,17-dodecahydrocyclopenta[a]phenanthren-3-one

The solubility of (16S,17R)-16,17-dihydroxy-13,16-dimethyl-1,2,6,7,8,9,10,11,12,14,15,17-dodecahydrocyclopenta[a]phenanthren-3-one is influenced by its unique chemical structure, particularly its hydroxyl groups and multiple methyl substituents. Here are some key points regarding its solubility:

  • Polarity: The presence of hydroxyl (-OH) groups can enhance solubility in polar solvents, such as water, because they can form hydrogen bonds.
  • Hydrophobic regions: The dodecahydrocyclopenta[a]phenanthrene structure contains considerable hydrophobic areas, which may limit solubility in purely aqueous environments.
  • Solvents: Likely to exhibit better solubility in organic solvents such as ethanol, methanol, or acetone due to its mixed polarity.
  • Temperature Effects: Generally, increased temperatures may improve solubility by enhancing molecular motion, especially in organic solvents.

In summary, while (16S,17R)-16,17-dihydroxy-13,16-dimethyl-1,2,6,7,8,9,10,11,12,14,15,17-dodecahydrocyclopenta[a]phenanthren-3-one may have some solubility in polar solvents due to its hydroxyl groups, challenges arise from its hydrophobic character. Therefore, careful selection of solvent is crucial for applications requiring dissolution of this compound.

Interesting facts

Exploring (16S,17R)-16,17-dihydroxy-13,16-dimethyl-1,2,6,7,8,9,10,11,12,14,15,17-dodecahydrocyclopenta[a]phenanthren-3-one

This compound is an interesting member of the steroid and polycyclic compound family, known for its complex structure and unique properties. Its synthesis and potential applications in medicinal chemistry make it a noteworthy subject of study.

Significance in Research

The compound is particularly notable for its potential biological activities. Here are a few key points of interest:

  • Biological Activity: Researchers are investigating its effects on steroidal behavior, which could lead to therapeutic developments.
  • Complex Structure: This compound features multiple hydroxyl groups and a unique dodecahydrocyclopenta framework that poses interesting challenges and opportunities for synthetic chemists.
  • Natural Sources: Many compounds with similar structures are derived from natural sources, raising potential for discovery in pharmacognosy.

Potential Uses

Given its structural characteristics, (16S,17R)-16,17-dihydroxy-13,16-dimethyl-1,2,6,7,8,9,10,11,12,14,15,17-dodecahydrocyclopenta[a]phenanthren-3-one could have various applications:

  • Investigation as a therapeutic agent against certain diseases.
  • Exploration in the development of new hormonal treatments.
  • Use in the study of steroid receptor interactions.

Quotes from the Field

As noted by renowned chemists, “The intricacies of steroid molecules often translate into powerful biological activity.” This compound serves as a perfect representation of that statement, showcasing the relationship between its architecture and possible physiological roles.

In summary, (16S,17R)-16,17-dihydroxy-13,16-dimethyl-1,2,6,7,8,9,10,11,12,14,15,17-dodecahydrocyclopenta[a]phenanthren-3-one exemplifies how the rich diversity of chemical compounds can unfold vast possibilities in scientific discovery and application.