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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
(16S,17R)-3-methoxy-13,16-dimethyl-7,8,9,11,12,14,15,17-octahydro-6H-cyclopenta[a]phenanthrene-16,17-diol
State
State

At room temperature, estradiol is in a solid state, appearing as a fine crystalline powder.

Melting point (Celsius)
176.00
Melting point (Kelvin)
449.15
Boiling point (Celsius)
370.00
Boiling point (Kelvin)
643.15
General information
Molecular weight
272.38g/mol
Molar mass
272.3810g/mol
Density
1.2000g/cm3
Appearence

Estradiol appears as a white to off-white crystalline powder. It is mostly odorless and is known for being poorly soluble in water but slightly soluble in alcohol.

Comment on solubility

Solubility of (16S,17R)-3-methoxy-13,16-dimethyl-7,8,9,11,12,14,15,17-octahydro-6H-cyclopenta[a]phenanthrene-16,17-diol

The solubility of this complex organic compound can be influenced by several key factors:

  • Molecular Structure: The presence of multiple functional groups, such as the hydroxyl (-OH) and methoxy (-OCH3) groups, typically enhances solubility in polar solvents due to hydrogen bonding capabilities.
  • Hydrophobic Character: The extensive fused ring system contributes a significant hydrophobic character that may hinder solubility in highly polar solvents.
  • Solvent Polarity: This compound is likely to be more soluble in organic solvents (such as ethanol or dichloromethane) than in water due to its larger hydrophobic regions.

In general:

  1. In Polar Solvents: Moderate solubility expected due to hydrogen bonding but can be limited by hydrophobic interactions.
  2. In Non-Polar Solvents: Higher solubility anticipated as the structure mimics the characteristics of the solvent.

Thus, while general predictions can be made about solubility based on structural analysis, experimental determination remains essential for precise evaluations.

As always, the solubility of this compound should be assessed carefully under specific conditions to garner the most accurate insights.

Interesting facts

Interesting Facts about (16S,17R)-3-methoxy-13,16-dimethyl-7,8,9,11,12,14,15,17-octahydro-6H-cyclopenta[a]phenanthrene-16,17-diol

This compound is a fascinating member of the steroid family, which play crucial roles in biological systems. Understanding its structure and properties can offer insight into various physiological processes.

Structural Highlights

  • Complexity: The compound features multiple chiral centers, making it a stereoisomer with distinct spatial arrangements that may lead to different biological activities.
  • Functional Groups: Notable for its methoxy and diol groups, which can enhance its reactivity and interaction with biological molecules.
  • Cyclic Structure: The presence of a cyclopenta[a]phenanthrene core contributes to its stability and provides a unique framework for interaction with receptors in biological systems.

Biological Relevance

The structure of this compound suggests potential applications in pharmacology, particularly in the design of drugs targeting hormonal pathways or influencing cell signaling. Compounds with similar structures have been implicated in:

  • Hormonal regulation: Many steroid-like compounds interact with hormone receptors, affecting numerous physiological functions.
  • Antitumor activity: Some derivatives exhibit anti-cancer properties, making them potential candidates for further research.
  • Neuroprotective effects: Certain sterols are known to provide protection against neurodegeneration.

Quote to Ponder

"The beauty of chemistry lies in its complexity; the more we understand, the more we realize how interconnected all substances are." This compound embodies this beauty, reflecting how intricate molecular designs can lead to significant biological implications.

As research continues into the properties of this compound, it may unveil novel pathways in therapy and drug development, showcasing the endless potential of chemical compounds in advancing science.

Synonyms
Manvene; Anvene; SC-6924