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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
17-(1-hydroxyethyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
State
State
At room temperature, estradiol is typically found in a solid state. It is an estrogen steroid hormone and requires proper handling due to its bioactivity.
Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
546.00
Boiling point (Kelvin)
819.15
General information
Molecular weight
272.38g/mol
Molar mass
272.3830g/mol
Density
1.1697g/cm3
Appearence
Estradiol is typically found as a crystalline powder or in a microcrystalline form. It tends to be white or nearly white in color.

The appearance can also reflect its high purity, and it may have a faint characteristic odor based on the method of preparation.

Comment on solubility

Solubility of 17-(1-hydroxyethyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol (C18H24O2)

The solubility of 17-(1-hydroxyethyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol is an intriguing aspect of this compound.

In the context of its solubility, several factors come into play:

  • Molecular Structure: The presence of hydroxyl (-OH) groups generally increases solubility in polar solvents such as water.
  • Hydrophobic Regions: The extensive hydrophobic hydrocarbon regions may limit solubility in highly polar solvents, affecting overall behavior in different media.
  • Interactions: Possible hydrogen bonding interactions with water could enhance solubility, while the bulky structure may present challenges.

Overall, one might summarize solubility as a balance between these competing forces. It is often observed that:

  • Compounds like this may be more soluble in organic solvents, such as ethanol or acetone, rather than in water.
  • Temperature and pH can also play critical roles in determining how effectively this compound dissolves in various environments.

As a general rule of thumb, the solubility of C18H24O2 in a given solvent can be empirically determined through various **solvent compatibility tests**, focusing particularly on its hydrocarbon and functional group interactions.

Interesting facts

Interesting Facts about 17-(1-hydroxyethyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol

This unique compound, often known by its more manageable name, is notable for several reasons in both organic chemistry and biochemistry. Here are some intriguing insights:

  • Structural Complexity: The compound features a complex fused ring system that includes multiple cyclopentane and phenanthrene-like structures. This intricate architecture is particularly interesting for synthetic chemists attempting to construct similar compounds.
  • Biological Relevance: Compounds of this class often exhibit biological activity, which can provide insights into their potential roles as pharmaceuticals or bioactive agents. They can act on hormonal systems due to their steroid-like backbone.
  • Potential Therapeutic Use: Given its structural similarities to certain hormones, this compound may hold promise in therapeutic applications, particularly in hormonal therapies or as anti-cancer agents.
  • Chemical Behavior: Understanding the behavior of this compound in different chemical environments helps in the study of metabolism and pharmacokinetics, potentially influencing drug design.
  • Research Opportunities: This compound serves as an excellent model for research in organic synthesis, medicinal chemistry, and the development of novel drugs.

"The study of complex organic molecules not only unravels the very fabric of life but also opens doors to innovative medicinal applications."

In summary, 17-(1-hydroxyethyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol stands as a fascinating compound that intertwines organic chemistry with medicinal implications, used as a tool for deeper understanding and advancement in chemical science.

Synonyms
Pregnane-3,20-diol
5alpha-Pregnane-3beta,20-diol
17-(1-hydroxyethyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
5alpha-Pregnane-3beta,20beta-diol
Pregnane-3,20-diol #
38270-91-6
5-beta-Pregnane-3-alpha,20-beta-diol
NCGC00160543-01
5.beta.-Pregnan-3.alpha.,20.alpha.-diol
5-ALPHA-PREGNAN-3-BETA, 20-ALPHA-DIOL
Oprea1_566549
SCHEMBL13979883
CHEBI:229017
YWYQTGBBEZQBGO-UHFFFAOYSA-N
NSC224267
AKOS004903632
NSC-224267
PD014487
5.alpha.-Pregnan-3.beta.,20.beta.-diol
DB-052002
NS00078816
NS00080023
5-BETA-PREGNANE-3-BETA,20-ALPHA-DIOL
Q906054
SR-01000945012
SR-01000945012-1
17-(1-HYDROXY-ETHYL)-10,13-DIMETHYL-HEXADECAHYDRO-CYCLOPENTA(A)PHENANTHREN-3-OL